Adaptive Multiple Testing Procedure for Clinical Trials with Urn Allocation
This work combines the Urn allocation and O’Brien and Fleming multiple testing procedure to compare two treatments in clinical trials in a novel way. It is shown that this approach overcomes the constraints that previously made it challenging to apply the original adaptive design to clinical trials....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Mathematics |
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| Online Access: | https://www.mdpi.com/2227-7390/11/18/3965 |
| _version_ | 1797578993229103104 |
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| author | Hanan Hammouri Mohammed Ali Marwan Alquran Areen Alquran Ruwa Abdel Muhsen Belal Alomari |
| author_facet | Hanan Hammouri Mohammed Ali Marwan Alquran Areen Alquran Ruwa Abdel Muhsen Belal Alomari |
| author_sort | Hanan Hammouri |
| collection | DOAJ |
| description | This work combines the Urn allocation and O’Brien and Fleming multiple testing procedure to compare two treatments in clinical trials in a novel way. It is shown that this approach overcomes the constraints that previously made it challenging to apply the original adaptive design to clinical trials. The method provides unique flexibility, enabling trials to be stopped early if one treatment shows it is superior without compromising the efficiency of the original multiple testing procedure in terms of type I error rate and power. Experimental data and simulated case examples are used to illustrate the efficacy and robustness of this original approach and its potential for usage in a variety of clinical settings. |
| first_indexed | 2024-03-10T22:30:32Z |
| format | Article |
| id | doaj.art-fe58bac11d0744c5b206a88b1e904097 |
| institution | Directory Open Access Journal |
| issn | 2227-7390 |
| language | English |
| last_indexed | 2024-03-10T22:30:32Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Mathematics |
| spelling | doaj.art-fe58bac11d0744c5b206a88b1e9040972023-11-19T11:50:04ZengMDPI AGMathematics2227-73902023-09-011118396510.3390/math11183965Adaptive Multiple Testing Procedure for Clinical Trials with Urn AllocationHanan Hammouri0Mohammed Ali1Marwan Alquran2Areen Alquran3Ruwa Abdel Muhsen4Belal Alomari5Department of Mathematics and Statistics, Faculty of Science and Art, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, JordanDepartment of Mathematics and Statistics, Faculty of Science and Art, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, JordanDepartment of Mathematics and Statistics, Faculty of Science and Art, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, JordanDepartment of Statistics, Yarmouk University, Irbid 21163, JordanDepartment of Mathematical Sciences, New Mexico State University, Las Cruces, NM 88001, USADepartment of Mathematics and Statistics, Faculty of Science and Art, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, JordanThis work combines the Urn allocation and O’Brien and Fleming multiple testing procedure to compare two treatments in clinical trials in a novel way. It is shown that this approach overcomes the constraints that previously made it challenging to apply the original adaptive design to clinical trials. The method provides unique flexibility, enabling trials to be stopped early if one treatment shows it is superior without compromising the efficiency of the original multiple testing procedure in terms of type I error rate and power. Experimental data and simulated case examples are used to illustrate the efficacy and robustness of this original approach and its potential for usage in a variety of clinical settings.https://www.mdpi.com/2227-7390/11/18/3965statistical algorithmsequential group testO’Brien and Flemingtype I error and powersimulationsSAS software |
| spellingShingle | Hanan Hammouri Mohammed Ali Marwan Alquran Areen Alquran Ruwa Abdel Muhsen Belal Alomari Adaptive Multiple Testing Procedure for Clinical Trials with Urn Allocation Mathematics statistical algorithm sequential group test O’Brien and Fleming type I error and power simulations SAS software |
| title | Adaptive Multiple Testing Procedure for Clinical Trials with Urn Allocation |
| title_full | Adaptive Multiple Testing Procedure for Clinical Trials with Urn Allocation |
| title_fullStr | Adaptive Multiple Testing Procedure for Clinical Trials with Urn Allocation |
| title_full_unstemmed | Adaptive Multiple Testing Procedure for Clinical Trials with Urn Allocation |
| title_short | Adaptive Multiple Testing Procedure for Clinical Trials with Urn Allocation |
| title_sort | adaptive multiple testing procedure for clinical trials with urn allocation |
| topic | statistical algorithm sequential group test O’Brien and Fleming type I error and power simulations SAS software |
| url | https://www.mdpi.com/2227-7390/11/18/3965 |
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