Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms
Spinal cord injury (SCI) has a major impact on affected patients due to its pathological consequences and absence of capacity for self-repair. Currently available therapies are unable to restore lost neural functions. Thus, there is a pressing need to develop novel treatments that will promote funct...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/11/3189 |
| _version_ | 1827677062530334720 |
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| author | Atefeh Zarepour Sara Hooshmand Aylin Gökmen Ali Zarrabi Ebrahim Mostafavi |
| author_facet | Atefeh Zarepour Sara Hooshmand Aylin Gökmen Ali Zarrabi Ebrahim Mostafavi |
| author_sort | Atefeh Zarepour |
| collection | DOAJ |
| description | Spinal cord injury (SCI) has a major impact on affected patients due to its pathological consequences and absence of capacity for self-repair. Currently available therapies are unable to restore lost neural functions. Thus, there is a pressing need to develop novel treatments that will promote functional repair after SCI. Several experimental approaches have been explored to tackle SCI, including the combination of stem cells and 3D bioprinting. Implanted multipotent stem cells with self-renewing capacity and the ability to differentiate to a diversity of cell types are promising candidates for replacing dead cells in injured sites and restoring disrupted neural circuits. However, implanted stem cells need protection from the inflammatory agents in the injured area and support to guide them to appropriate differentiation. Not only are 3D bioprinted scaffolds able to protect stem cells, but they can also promote their differentiation and functional integration at the site of injury. In this review, we showcase some recent advances in the use of stem cells for the treatment of SCI, different types of 3D bioprinting methods, and the combined application of stem cells and 3D bioprinting technique for effective repair of SCI. |
| first_indexed | 2024-03-10T05:36:57Z |
| format | Article |
| id | doaj.art-fe59a2505b2a4984a0c4bfa989b4544c |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T05:36:57Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-fe59a2505b2a4984a0c4bfa989b4544c2023-11-22T22:52:37ZengMDPI AGCells2073-44092021-11-011011318910.3390/cells10113189Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted PlatformsAtefeh Zarepour0Sara Hooshmand1Aylin Gökmen2Ali Zarrabi3Ebrahim Mostafavi4Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul 34396, TurkeyNanotechnology Research and Application Center (SUNUM), Sabanci University, Istanbul 34956, TurkeyMolecular Biology and Genetics Department, Faculty of Engineering and Natural Sciences, Bahcesehir University, Istanbul 34353, TurkeyDepartment of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul 34396, TurkeyStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USASpinal cord injury (SCI) has a major impact on affected patients due to its pathological consequences and absence of capacity for self-repair. Currently available therapies are unable to restore lost neural functions. Thus, there is a pressing need to develop novel treatments that will promote functional repair after SCI. Several experimental approaches have been explored to tackle SCI, including the combination of stem cells and 3D bioprinting. Implanted multipotent stem cells with self-renewing capacity and the ability to differentiate to a diversity of cell types are promising candidates for replacing dead cells in injured sites and restoring disrupted neural circuits. However, implanted stem cells need protection from the inflammatory agents in the injured area and support to guide them to appropriate differentiation. Not only are 3D bioprinted scaffolds able to protect stem cells, but they can also promote their differentiation and functional integration at the site of injury. In this review, we showcase some recent advances in the use of stem cells for the treatment of SCI, different types of 3D bioprinting methods, and the combined application of stem cells and 3D bioprinting technique for effective repair of SCI.https://www.mdpi.com/2073-4409/10/11/3189spinal cord injurystem cells3D bioprintingtissue regenerationneural tissue engineering |
| spellingShingle | Atefeh Zarepour Sara Hooshmand Aylin Gökmen Ali Zarrabi Ebrahim Mostafavi Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms Cells spinal cord injury stem cells 3D bioprinting tissue regeneration neural tissue engineering |
| title | Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms |
| title_full | Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms |
| title_fullStr | Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms |
| title_full_unstemmed | Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms |
| title_short | Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms |
| title_sort | spinal cord injury management through the combination of stem cells and implantable 3d bioprinted platforms |
| topic | spinal cord injury stem cells 3D bioprinting tissue regeneration neural tissue engineering |
| url | https://www.mdpi.com/2073-4409/10/11/3189 |
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