The Impact of Hypromellose on Pharmaceutical Properties of Alginate Microparticles as Novel Drug Carriers for Posaconazole
Fungal infections are a group of diseases which are challenging to treat because of drug-resistant fungi species, drug toxicity, and often severe patient conditions. Hence, research into new treatments, including new therapeutic substances and novel drug delivery systems, is being performed. Mucoadh...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/13/10793 |
| _version_ | 1797591598107721728 |
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| author | Katarzyna Kruk Marta Szekalska Anna Basa Katarzyna Winnicka |
| author_facet | Katarzyna Kruk Marta Szekalska Anna Basa Katarzyna Winnicka |
| author_sort | Katarzyna Kruk |
| collection | DOAJ |
| description | Fungal infections are a group of diseases which are challenging to treat because of drug-resistant fungi species, drug toxicity, and often severe patient conditions. Hence, research into new treatments, including new therapeutic substances and novel drug delivery systems, is being performed. Mucoadhesive dosage forms are beneficial to improving drug bioavailability by prolonging the residence time at the site of application. Sodium alginate is a natural polymer with favorable mucoadhesive and gelling properties, although its precipitation in acidic pH significantly disrupts the process of drug release in gastric conditions. Hypromellose is a hydrophilic, semi-synthetic cellulose derivative with mucoadhesive properties, which is widely used as a control release agent in pharmaceutical technology. The aim of this study was to evaluate the impact of hypromellose on alginate microparticles with posaconazole, designed to modify drug release and to improve their mucoadhesive properties for both oral or vaginal application. |
| first_indexed | 2024-03-11T01:39:37Z |
| format | Article |
| id | doaj.art-fe5a2bcb2d0345a3bc851c8569d300c4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T01:39:37Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fe5a2bcb2d0345a3bc851c8569d300c42023-11-18T16:43:39ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124131079310.3390/ijms241310793The Impact of Hypromellose on Pharmaceutical Properties of Alginate Microparticles as Novel Drug Carriers for PosaconazoleKatarzyna Kruk0Marta Szekalska1Anna Basa2Katarzyna Winnicka3Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2C, 15-222 Białystok, PolandDepartment of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2C, 15-222 Białystok, PolandInstitute of Chemistry, University of Białystok, Ciołkowskiego 1K, 15-245 Białystok, PolandDepartment of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2C, 15-222 Białystok, PolandFungal infections are a group of diseases which are challenging to treat because of drug-resistant fungi species, drug toxicity, and often severe patient conditions. Hence, research into new treatments, including new therapeutic substances and novel drug delivery systems, is being performed. Mucoadhesive dosage forms are beneficial to improving drug bioavailability by prolonging the residence time at the site of application. Sodium alginate is a natural polymer with favorable mucoadhesive and gelling properties, although its precipitation in acidic pH significantly disrupts the process of drug release in gastric conditions. Hypromellose is a hydrophilic, semi-synthetic cellulose derivative with mucoadhesive properties, which is widely used as a control release agent in pharmaceutical technology. The aim of this study was to evaluate the impact of hypromellose on alginate microparticles with posaconazole, designed to modify drug release and to improve their mucoadhesive properties for both oral or vaginal application.https://www.mdpi.com/1422-0067/24/13/10793alginatehypromelloseposaconazolemicroparticlesmucoadhesive formulations |
| spellingShingle | Katarzyna Kruk Marta Szekalska Anna Basa Katarzyna Winnicka The Impact of Hypromellose on Pharmaceutical Properties of Alginate Microparticles as Novel Drug Carriers for Posaconazole International Journal of Molecular Sciences alginate hypromellose posaconazole microparticles mucoadhesive formulations |
| title | The Impact of Hypromellose on Pharmaceutical Properties of Alginate Microparticles as Novel Drug Carriers for Posaconazole |
| title_full | The Impact of Hypromellose on Pharmaceutical Properties of Alginate Microparticles as Novel Drug Carriers for Posaconazole |
| title_fullStr | The Impact of Hypromellose on Pharmaceutical Properties of Alginate Microparticles as Novel Drug Carriers for Posaconazole |
| title_full_unstemmed | The Impact of Hypromellose on Pharmaceutical Properties of Alginate Microparticles as Novel Drug Carriers for Posaconazole |
| title_short | The Impact of Hypromellose on Pharmaceutical Properties of Alginate Microparticles as Novel Drug Carriers for Posaconazole |
| title_sort | impact of hypromellose on pharmaceutical properties of alginate microparticles as novel drug carriers for posaconazole |
| topic | alginate hypromellose posaconazole microparticles mucoadhesive formulations |
| url | https://www.mdpi.com/1422-0067/24/13/10793 |
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