Preclinical study of simultaneous pharmacokinetic and pharmacodynamic herb-drug interactions between Yin-Chen-Hao-Tang and spironolactone
Abstract Background The prevalence and therapeutic effects of the use of herbal remedies for chronic liver diseases make the combined administration of herbal products with conventional treatment unable to be ignored. This study investigated the pharmacokinetic and pharmacodynamic herb-drug interact...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-08-01
|
| Series: | BMC Complementary Medicine and Therapies |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12906-020-03042-y |
| _version_ | 1818479475154747392 |
|---|---|
| author | Tun-Pin Hsueh Tung-Hu Tsai |
| author_facet | Tun-Pin Hsueh Tung-Hu Tsai |
| author_sort | Tun-Pin Hsueh |
| collection | DOAJ |
| description | Abstract Background The prevalence and therapeutic effects of the use of herbal remedies for chronic liver diseases make the combined administration of herbal products with conventional treatment unable to be ignored. This study investigated the pharmacokinetic and pharmacodynamic herb-drug interactions between the herbal formula Yin-Chen-Hao-Tang (YCHT) and spironolactone. Methods A selective high-performance liquid chromatography (HPLC) method was developed and validated for the detection of spironolactone and its metabolite canrenone in rat urine. The interaction study was conducted by collecting urine samples after oral administration of spironolactone alone or in combination with YCHT for 5 days. Urine pharmacokinetic parameters and urinary sodium, potassium, volume, and weight were analyzed. Results The results revealed significant increases in the cumulative amount and the area under the rate curve (AURC) of the metabolite canrenone after pretreatment with the high dose of YCHT. The urine weight and volume were significantly reduced dose-dependently as a result of pretreatment with YCHT. The urinary sodium-to-potassium ratio, which indicates diuretic effects, was also reduced in the high-dose YCHT condition. Conclusions Herb-drug pharmacokinetic and pharmacodynamic interactions between YCHT and spironolactone were observed in the study. The herb-drug interaction that appeared with a single dose of spironolactone should be considered when patients are being treated with a continuous administration of this drug. |
| first_indexed | 2024-12-10T11:11:04Z |
| format | Article |
| id | doaj.art-fe5c4973a36b46a4a369d50fb018e56e |
| institution | Directory Open Access Journal |
| issn | 2662-7671 |
| language | English |
| last_indexed | 2024-12-10T11:11:04Z |
| publishDate | 2020-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary Medicine and Therapies |
| spelling | doaj.art-fe5c4973a36b46a4a369d50fb018e56e2022-12-22T01:51:25ZengBMCBMC Complementary Medicine and Therapies2662-76712020-08-012011910.1186/s12906-020-03042-yPreclinical study of simultaneous pharmacokinetic and pharmacodynamic herb-drug interactions between Yin-Chen-Hao-Tang and spironolactoneTun-Pin Hsueh0Tung-Hu Tsai1Institute of Traditional Medicine, School of Medicine, National Yang-Ming UniversityInstitute of Traditional Medicine, School of Medicine, National Yang-Ming UniversityAbstract Background The prevalence and therapeutic effects of the use of herbal remedies for chronic liver diseases make the combined administration of herbal products with conventional treatment unable to be ignored. This study investigated the pharmacokinetic and pharmacodynamic herb-drug interactions between the herbal formula Yin-Chen-Hao-Tang (YCHT) and spironolactone. Methods A selective high-performance liquid chromatography (HPLC) method was developed and validated for the detection of spironolactone and its metabolite canrenone in rat urine. The interaction study was conducted by collecting urine samples after oral administration of spironolactone alone or in combination with YCHT for 5 days. Urine pharmacokinetic parameters and urinary sodium, potassium, volume, and weight were analyzed. Results The results revealed significant increases in the cumulative amount and the area under the rate curve (AURC) of the metabolite canrenone after pretreatment with the high dose of YCHT. The urine weight and volume were significantly reduced dose-dependently as a result of pretreatment with YCHT. The urinary sodium-to-potassium ratio, which indicates diuretic effects, was also reduced in the high-dose YCHT condition. Conclusions Herb-drug pharmacokinetic and pharmacodynamic interactions between YCHT and spironolactone were observed in the study. The herb-drug interaction that appeared with a single dose of spironolactone should be considered when patients are being treated with a continuous administration of this drug.http://link.springer.com/article/10.1186/s12906-020-03042-yArtemisiaDrug interactionHerbal medicineSpironolactoneLiver disease |
| spellingShingle | Tun-Pin Hsueh Tung-Hu Tsai Preclinical study of simultaneous pharmacokinetic and pharmacodynamic herb-drug interactions between Yin-Chen-Hao-Tang and spironolactone BMC Complementary Medicine and Therapies Artemisia Drug interaction Herbal medicine Spironolactone Liver disease |
| title | Preclinical study of simultaneous pharmacokinetic and pharmacodynamic herb-drug interactions between Yin-Chen-Hao-Tang and spironolactone |
| title_full | Preclinical study of simultaneous pharmacokinetic and pharmacodynamic herb-drug interactions between Yin-Chen-Hao-Tang and spironolactone |
| title_fullStr | Preclinical study of simultaneous pharmacokinetic and pharmacodynamic herb-drug interactions between Yin-Chen-Hao-Tang and spironolactone |
| title_full_unstemmed | Preclinical study of simultaneous pharmacokinetic and pharmacodynamic herb-drug interactions between Yin-Chen-Hao-Tang and spironolactone |
| title_short | Preclinical study of simultaneous pharmacokinetic and pharmacodynamic herb-drug interactions between Yin-Chen-Hao-Tang and spironolactone |
| title_sort | preclinical study of simultaneous pharmacokinetic and pharmacodynamic herb drug interactions between yin chen hao tang and spironolactone |
| topic | Artemisia Drug interaction Herbal medicine Spironolactone Liver disease |
| url | http://link.springer.com/article/10.1186/s12906-020-03042-y |
| work_keys_str_mv | AT tunpinhsueh preclinicalstudyofsimultaneouspharmacokineticandpharmacodynamicherbdruginteractionsbetweenyinchenhaotangandspironolactone AT tunghutsai preclinicalstudyofsimultaneouspharmacokineticandpharmacodynamicherbdruginteractionsbetweenyinchenhaotangandspironolactone |