Molecular Programming of Mesodiencephalic Dopaminergic Neuronal Subsets
Dopamine neurons of the substantia nigra compacta (SNc) and ventral tegmental area (VTA) are critical components of the neuronal machinery to control emotion and movement in mammals. The slow and gradual death of these neurons as seen in Parkinson's disease has triggered a large investment in r...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-07-01
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| Series: | Frontiers in Neuroanatomy |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnana.2017.00059/full |
| _version_ | 1828437032159936512 |
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| author | Marten P. Smidt |
| author_facet | Marten P. Smidt |
| author_sort | Marten P. Smidt |
| collection | DOAJ |
| description | Dopamine neurons of the substantia nigra compacta (SNc) and ventral tegmental area (VTA) are critical components of the neuronal machinery to control emotion and movement in mammals. The slow and gradual death of these neurons as seen in Parkinson's disease has triggered a large investment in research toward unraveling the molecular determinants that are used to generate these neurons and to get an insight in their apparent selective vulnerability. Here, I set out to summarize the current view on the molecular distinctions that exist within this mesodiencephalic dopamine (mdDA) system and elaborate on the molecular programming that is responsible for creating such diversity. |
| first_indexed | 2024-12-10T19:37:52Z |
| format | Article |
| id | doaj.art-fe602ad839684a14a31c1a6359c9d6e2 |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-12-10T19:37:52Z |
| publishDate | 2017-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-fe602ad839684a14a31c1a6359c9d6e22022-12-22T01:36:05ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292017-07-011110.3389/fnana.2017.00059284592Molecular Programming of Mesodiencephalic Dopaminergic Neuronal SubsetsMarten P. SmidtDopamine neurons of the substantia nigra compacta (SNc) and ventral tegmental area (VTA) are critical components of the neuronal machinery to control emotion and movement in mammals. The slow and gradual death of these neurons as seen in Parkinson's disease has triggered a large investment in research toward unraveling the molecular determinants that are used to generate these neurons and to get an insight in their apparent selective vulnerability. Here, I set out to summarize the current view on the molecular distinctions that exist within this mesodiencephalic dopamine (mdDA) system and elaborate on the molecular programming that is responsible for creating such diversity.http://journal.frontiersin.org/article/10.3389/fnana.2017.00059/fulldopaminedifferentiationspecificationdevelopmentmesencephalonmolecular coding |
| spellingShingle | Marten P. Smidt Molecular Programming of Mesodiencephalic Dopaminergic Neuronal Subsets Frontiers in Neuroanatomy dopamine differentiation specification development mesencephalon molecular coding |
| title | Molecular Programming of Mesodiencephalic Dopaminergic Neuronal Subsets |
| title_full | Molecular Programming of Mesodiencephalic Dopaminergic Neuronal Subsets |
| title_fullStr | Molecular Programming of Mesodiencephalic Dopaminergic Neuronal Subsets |
| title_full_unstemmed | Molecular Programming of Mesodiencephalic Dopaminergic Neuronal Subsets |
| title_short | Molecular Programming of Mesodiencephalic Dopaminergic Neuronal Subsets |
| title_sort | molecular programming of mesodiencephalic dopaminergic neuronal subsets |
| topic | dopamine differentiation specification development mesencephalon molecular coding |
| url | http://journal.frontiersin.org/article/10.3389/fnana.2017.00059/full |
| work_keys_str_mv | AT martenpsmidt molecularprogrammingofmesodiencephalicdopaminergicneuronalsubsets |