Ocular Manifestations in Patients with Philadelphia-Negative Myeloproliferative Neoplasms
The major complications of Philadelphia-negative (Ph-Negative) myeloproliferative neoplasms (MPNs) are thrombosis, haemorrhage and leukemic transformation. As systemic and haematological diseases, MPNs have the potential to affect many tissues and organs. Some complications lead to the diagnosis of...
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| Format: | Article |
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MDPI AG
2020-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/3/573 |
| _version_ | 1797708365360529408 |
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| author | Charlotte Liisborg Hans Carl Hasselbalch Torben Lykke Sørensen |
| author_facet | Charlotte Liisborg Hans Carl Hasselbalch Torben Lykke Sørensen |
| author_sort | Charlotte Liisborg |
| collection | DOAJ |
| description | The major complications of Philadelphia-negative (Ph-Negative) myeloproliferative neoplasms (MPNs) are thrombosis, haemorrhage and leukemic transformation. As systemic and haematological diseases, MPNs have the potential to affect many tissues and organs. Some complications lead to the diagnosis of MPNs, but other signs and symptoms are often misdiagnosed or neglected as a sign of MPN disease. Therefore, we reviewed the current literature to investigate and delineate the clinical manifestations seen in the eyes of Ph-negative MPN patients. We found that ocular manifestations are common among patients with MPNs. The most frequently described manifestations are due to the consequences of haematological abnormalities causing microvascular disturbances and hyperviscosity. More serious and vision-threatening complications as thrombotic events in the eyes have been repeatedly reported as well. These ocular symptoms may precede more serious extraocular complications. Accordingly, combined ophthalmological and haematological management have the potential to discover these diseases earlier and prevent morbidity and mortality in these patients. Furthermore, routine ophthalmological screening of all newly diagnosed MPN patients may be a preventive approach for early diagnosis and timely treatment of the ocular manifestations. |
| first_indexed | 2024-03-12T06:20:23Z |
| format | Article |
| id | doaj.art-fe607fd893a74b73bb7359e562cf7554 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T06:20:23Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-fe607fd893a74b73bb7359e562cf75542023-09-03T02:17:49ZengMDPI AGCancers2072-66942020-03-0112357310.3390/cancers12030573cancers12030573Ocular Manifestations in Patients with Philadelphia-Negative Myeloproliferative NeoplasmsCharlotte Liisborg0Hans Carl Hasselbalch1Torben Lykke Sørensen2Department of Ophthalmology, Zealand University Hospital, Vestermarksvej 23, 4000 Roskilde, DenmarkFaculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, DenmarkDepartment of Ophthalmology, Zealand University Hospital, Vestermarksvej 23, 4000 Roskilde, DenmarkThe major complications of Philadelphia-negative (Ph-Negative) myeloproliferative neoplasms (MPNs) are thrombosis, haemorrhage and leukemic transformation. As systemic and haematological diseases, MPNs have the potential to affect many tissues and organs. Some complications lead to the diagnosis of MPNs, but other signs and symptoms are often misdiagnosed or neglected as a sign of MPN disease. Therefore, we reviewed the current literature to investigate and delineate the clinical manifestations seen in the eyes of Ph-negative MPN patients. We found that ocular manifestations are common among patients with MPNs. The most frequently described manifestations are due to the consequences of haematological abnormalities causing microvascular disturbances and hyperviscosity. More serious and vision-threatening complications as thrombotic events in the eyes have been repeatedly reported as well. These ocular symptoms may precede more serious extraocular complications. Accordingly, combined ophthalmological and haematological management have the potential to discover these diseases earlier and prevent morbidity and mortality in these patients. Furthermore, routine ophthalmological screening of all newly diagnosed MPN patients may be a preventive approach for early diagnosis and timely treatment of the ocular manifestations.https://www.mdpi.com/2072-6694/12/3/573ocular manifestationsocular complicationsphiladelphia-negative myeloproliferative neoplasms |
| spellingShingle | Charlotte Liisborg Hans Carl Hasselbalch Torben Lykke Sørensen Ocular Manifestations in Patients with Philadelphia-Negative Myeloproliferative Neoplasms Cancers ocular manifestations ocular complications philadelphia-negative myeloproliferative neoplasms |
| title | Ocular Manifestations in Patients with Philadelphia-Negative Myeloproliferative Neoplasms |
| title_full | Ocular Manifestations in Patients with Philadelphia-Negative Myeloproliferative Neoplasms |
| title_fullStr | Ocular Manifestations in Patients with Philadelphia-Negative Myeloproliferative Neoplasms |
| title_full_unstemmed | Ocular Manifestations in Patients with Philadelphia-Negative Myeloproliferative Neoplasms |
| title_short | Ocular Manifestations in Patients with Philadelphia-Negative Myeloproliferative Neoplasms |
| title_sort | ocular manifestations in patients with philadelphia negative myeloproliferative neoplasms |
| topic | ocular manifestations ocular complications philadelphia-negative myeloproliferative neoplasms |
| url | https://www.mdpi.com/2072-6694/12/3/573 |
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