Reversible adrenal insufficiency and heterophile antibodies in a case of autoimmune polyendocrinopathy syndrome
A 27-year-old male was admitted with diabetic ketoacidosis and altered sensorium with slurring of speech and ataxia. He was managed with intravenous insulin and fluids and later shifted to basal bolus insulin regimen and during further evaluation was diagnosed to be suffering from primary hypothyroi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2013;volume=17;issue=9;spage=700;epage=702;aulast=Kharb |
| _version_ | 1818014734619770880 |
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| author | Sandeep Kharb Abhay Gundgurthi Manoj K Dutta M K Garg |
| author_facet | Sandeep Kharb Abhay Gundgurthi Manoj K Dutta M K Garg |
| author_sort | Sandeep Kharb |
| collection | DOAJ |
| description | A 27-year-old male was admitted with diabetic ketoacidosis and altered sensorium with slurring of speech and ataxia. He was managed with intravenous insulin and fluids and later shifted to basal bolus insulin regimen and during further evaluation was diagnosed to be suffering from primary hypothyroidism and adrenal insufficiency. He was started on thyroxin replacement and steroids only during stress. After three months of follow up he was clinically euthyroid. His glycemic control was adequate on oral anti-hyperglycemic drugs and adrenal insufficiency recovered. However, his thyrotropin levels were persistently elevated on adequate replacement doses of thyroxin. His repeat TSH was estimated after precipitating serum with polyethylene glycol which revealed normal TSH. Here we report reversible adrenal insufficiency with hypothyroidism with falsely raised TSH because of presence of heterophile antibodies in a case of poly glandular endocrinopathy syndrome. |
| first_indexed | 2024-04-14T06:48:06Z |
| format | Article |
| id | doaj.art-fe61c3a0e6f2477aa41e9b93306296ea |
| institution | Directory Open Access Journal |
| issn | 2230-8210 2230-9500 |
| language | English |
| last_indexed | 2024-04-14T06:48:06Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-fe61c3a0e6f2477aa41e9b93306296ea2022-12-22T02:07:06ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002013-01-0117970070210.4103/2230-8210.123572Reversible adrenal insufficiency and heterophile antibodies in a case of autoimmune polyendocrinopathy syndromeSandeep KharbAbhay GundgurthiManoj K DuttaM K GargA 27-year-old male was admitted with diabetic ketoacidosis and altered sensorium with slurring of speech and ataxia. He was managed with intravenous insulin and fluids and later shifted to basal bolus insulin regimen and during further evaluation was diagnosed to be suffering from primary hypothyroidism and adrenal insufficiency. He was started on thyroxin replacement and steroids only during stress. After three months of follow up he was clinically euthyroid. His glycemic control was adequate on oral anti-hyperglycemic drugs and adrenal insufficiency recovered. However, his thyrotropin levels were persistently elevated on adequate replacement doses of thyroxin. His repeat TSH was estimated after precipitating serum with polyethylene glycol which revealed normal TSH. Here we report reversible adrenal insufficiency with hypothyroidism with falsely raised TSH because of presence of heterophile antibodies in a case of poly glandular endocrinopathy syndrome.http://www.ijem.in/article.asp?issn=2230-8210;year=2013;volume=17;issue=9;spage=700;epage=702;aulast=KharbAdrenal insufficiencyautoimmune polyendocrinopathy syndromeheterophile antibodyprimary hypothyroidismtype-1 diabetes mellitus |
| spellingShingle | Sandeep Kharb Abhay Gundgurthi Manoj K Dutta M K Garg Reversible adrenal insufficiency and heterophile antibodies in a case of autoimmune polyendocrinopathy syndrome Indian Journal of Endocrinology and Metabolism Adrenal insufficiency autoimmune polyendocrinopathy syndrome heterophile antibody primary hypothyroidism type-1 diabetes mellitus |
| title | Reversible adrenal insufficiency and heterophile antibodies in a case of autoimmune polyendocrinopathy syndrome |
| title_full | Reversible adrenal insufficiency and heterophile antibodies in a case of autoimmune polyendocrinopathy syndrome |
| title_fullStr | Reversible adrenal insufficiency and heterophile antibodies in a case of autoimmune polyendocrinopathy syndrome |
| title_full_unstemmed | Reversible adrenal insufficiency and heterophile antibodies in a case of autoimmune polyendocrinopathy syndrome |
| title_short | Reversible adrenal insufficiency and heterophile antibodies in a case of autoimmune polyendocrinopathy syndrome |
| title_sort | reversible adrenal insufficiency and heterophile antibodies in a case of autoimmune polyendocrinopathy syndrome |
| topic | Adrenal insufficiency autoimmune polyendocrinopathy syndrome heterophile antibody primary hypothyroidism type-1 diabetes mellitus |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2013;volume=17;issue=9;spage=700;epage=702;aulast=Kharb |
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