Blastic plasmacytoid dendritic cell neoplasm presenting as fever with diffuse cutaneous nodules
A young man, presented with high-grade fever and disseminated asymptomatic skin lesions of 6-weeks duration. Cutaneous examination revealed multiple infiltrated monomorphic skin-colored papules and nodules upto 2Χ2 cm all over scalp, face, trunk and extremities. Light microscopy of nodules showed di...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Indian Journal of Dermatology |
| Subjects: | |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2012;volume=57;issue=1;spage=45;epage=47;aulast=Dincy |
| _version_ | 1818858508948340736 |
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| author | C V Dincy Peter Anupam Chakrapani Sanjeev Shah Apurva Shah Alok Srivastava |
| author_facet | C V Dincy Peter Anupam Chakrapani Sanjeev Shah Apurva Shah Alok Srivastava |
| author_sort | C V Dincy Peter |
| collection | DOAJ |
| description | A young man, presented with high-grade fever and disseminated asymptomatic skin lesions of 6-weeks duration. Cutaneous examination revealed multiple infiltrated monomorphic skin-colored papules and nodules upto 2Χ2 cm all over scalp, face, trunk and extremities. Light microscopy of nodules showed diffuse infiltration of dermis and subcutis by a tumor composed of medium to large cells with round to ovoid nuclei with fine chromatin, few with visible nucleoli and scanty to moderate amounts of eosinophilic cytoplasm. Tumor cells were positive for CD4, CD8, CD56 and negative for CD30, terminal deoxynucleotidyl transferase and Alk-1. Excised axillary lymph node showed similar morphologic and immunohistochemical findings. There was bone marrow involvement with infiltrate of large atypical/immature lymphoid cells. Diagnosis of blastic plasmacytoid dendritic cell neoplasm was made. This is a rare neoplasm. presenting commonly in the skin, with or without concurrent extracutaneous disease. |
| first_indexed | 2024-12-19T08:57:25Z |
| format | Article |
| id | doaj.art-fe627e0ac17444ec9983ea7c957556b5 |
| institution | Directory Open Access Journal |
| issn | 0019-5154 1998-3611 |
| language | English |
| last_indexed | 2024-12-19T08:57:25Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj.art-fe627e0ac17444ec9983ea7c957556b52022-12-21T20:28:34ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112012-01-01571454710.4103/0019-5154.92677Blastic plasmacytoid dendritic cell neoplasm presenting as fever with diffuse cutaneous nodulesC V Dincy PeterAnupam ChakrapaniSanjeev ShahApurva ShahAlok SrivastavaA young man, presented with high-grade fever and disseminated asymptomatic skin lesions of 6-weeks duration. Cutaneous examination revealed multiple infiltrated monomorphic skin-colored papules and nodules upto 2Χ2 cm all over scalp, face, trunk and extremities. Light microscopy of nodules showed diffuse infiltration of dermis and subcutis by a tumor composed of medium to large cells with round to ovoid nuclei with fine chromatin, few with visible nucleoli and scanty to moderate amounts of eosinophilic cytoplasm. Tumor cells were positive for CD4, CD8, CD56 and negative for CD30, terminal deoxynucleotidyl transferase and Alk-1. Excised axillary lymph node showed similar morphologic and immunohistochemical findings. There was bone marrow involvement with infiltrate of large atypical/immature lymphoid cells. Diagnosis of blastic plasmacytoid dendritic cell neoplasm was made. This is a rare neoplasm. presenting commonly in the skin, with or without concurrent extracutaneous disease.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2012;volume=57;issue=1;spage=45;epage=47;aulast=DincyBlastic plasmacytoid dendritic cell neoplasmcutaneous nodulesfever |
| spellingShingle | C V Dincy Peter Anupam Chakrapani Sanjeev Shah Apurva Shah Alok Srivastava Blastic plasmacytoid dendritic cell neoplasm presenting as fever with diffuse cutaneous nodules Indian Journal of Dermatology Blastic plasmacytoid dendritic cell neoplasm cutaneous nodules fever |
| title | Blastic plasmacytoid dendritic cell neoplasm presenting as fever with diffuse cutaneous nodules |
| title_full | Blastic plasmacytoid dendritic cell neoplasm presenting as fever with diffuse cutaneous nodules |
| title_fullStr | Blastic plasmacytoid dendritic cell neoplasm presenting as fever with diffuse cutaneous nodules |
| title_full_unstemmed | Blastic plasmacytoid dendritic cell neoplasm presenting as fever with diffuse cutaneous nodules |
| title_short | Blastic plasmacytoid dendritic cell neoplasm presenting as fever with diffuse cutaneous nodules |
| title_sort | blastic plasmacytoid dendritic cell neoplasm presenting as fever with diffuse cutaneous nodules |
| topic | Blastic plasmacytoid dendritic cell neoplasm cutaneous nodules fever |
| url | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2012;volume=57;issue=1;spage=45;epage=47;aulast=Dincy |
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