Key Positions of HIV-1 Env and Signatures of Vaccine Efficacy Show Gradual Reduction of Population Founder Effects at the Clade and Regional Levels

Key Positions of HIV-1 Env and Signatures of Vaccine Efficacy Show Gradual Reduction of Population Founder Effects at the Clade and Regional Levels

ABSTRACT HIV-1 group M was transmitted to humans nearly one century ago. The virus has since evolved to form distinct clades, which spread to different regions of the world. The envelope glycoproteins (Envs) of HIV-1 have rapidly diversified in all infected populations. We examined whether key antig...

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Bibliographic Details
Main Authors: Changze Han, Jacklyn Johnson, Rentian Dong, Raghavendranath Kandula, Alexa Kort, Maria Wong, Tianbao Yang, Patrick J. Breheny, Grant D. Brown, Hillel Haim
Format: Article
Language:English
Published: American Society for Microbiology 2020-06-01
Series:mBio
Subjects:
HIV-1
envelope glycoproteins
population-level evolution
vaccine design
virus diversity
Online Access:https://journals.asm.org/doi/10.1128/mBio.00126-20

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