The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms

The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms

Abstract Background Previous studies show that antibiotic-mediated (abx) alteration of the gut microbiome (GMB) results in a reduction of amyloid beta (Aβ) plaques and proinflammatory microglial phenotype in male APPPS1-21 mice. However, the effect of GMB perturbation on astrocyte phenotypes and mic...

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Bibliographic Details
Main Authors: Sidhanth Chandra, Antonio Di Meco, Hemraj B. Dodiya, Jelena Popovic, Leah K. Cuddy, Ian Q. Weigle, Xiaoqiong Zhang, Katherine Sadleir, Sangram S. Sisodia, Robert Vassar
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Molecular Neurodegeneration
Subjects:
Astrocyte
Neuroinflammation
Gut microbiome
Amyloid
Online Access:https://doi.org/10.1186/s13024-023-00635-2

Internet

https://doi.org/10.1186/s13024-023-00635-2

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