The association between dietary branched-chain amino acids and the risk of cardiovascular diseases in Chinese patients with type 2 diabetes: A hospital-based case–control study
BackgroundPrevious studies showed conflicting evidence on the association between the intake of dietary branched-chain amino acid (BCAA) and the risk of cardiovascular disease (CVD). However, this relationship has not been studied in patients with type 2 diabetes. Therefore, we evaluated the effects...
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.999189/full |
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| author | Lu Zheng Jun Cai Yong-hui Feng Xin Su Shi-yun Chen Jia-zi Liu Wan-lin Li Rui-qing Ouyang Jun-rong Ma Chen Cheng Ying-jun Mu Shi-wen Zhang Kai-yin He Fang-fang Zeng Yan-bin Ye Yan-bin Ye |
| author_facet | Lu Zheng Jun Cai Yong-hui Feng Xin Su Shi-yun Chen Jia-zi Liu Wan-lin Li Rui-qing Ouyang Jun-rong Ma Chen Cheng Ying-jun Mu Shi-wen Zhang Kai-yin He Fang-fang Zeng Yan-bin Ye Yan-bin Ye |
| author_sort | Lu Zheng |
| collection | DOAJ |
| description | BackgroundPrevious studies showed conflicting evidence on the association between the intake of dietary branched-chain amino acid (BCAA) and the risk of cardiovascular disease (CVD). However, this relationship has not been studied in patients with type 2 diabetes. Therefore, we evaluated the effects of total and individual dietary BCAA (leucine, isoleucine, and valine) intake on CVD risk among individuals with type 2 diabetes in China.Materials and methodsA total of 419 patients with type 2 diabetes who have been diagnosed with CVD (within 2 weeks) were recruited between March 2013 and September 2015 in China. Cases with CVD were 1:1 matched to controls with type 2 diabetes but without CVD by age (±5 years) and sex. A validated 79-item semiquantitative food frequency questionnaire (FFQ) was administered to assess the participants' dietary data. Total dietary BCAA per individual was the summation of the daily intake of isoleucine, leucine, and valine. OR and corresponding CIs were computed by conditional logistic regression models adjusted for potential confounders.ResultsMedian values of the daily intake of total BCAA were 11.87 g, with an interquartile range of 10.46–13.15 g for cases, and 12.47 g, with an interquartile range of 11.08–13.79 g for controls (P = 0.001). Dietary BCAA was inversely related to CVD risk after multivariable adjustment (OR Q4−Q1 = 0.23, 95%CI = 0.10, 0.51, P trend <0.001 for total BCAA; OR Q4−Q1 = 0.20, 95%CI = 0.07, 0.53, P trend = 0.001 for leucine). For each 1-S.D. increase in total dietary BCAA, leucine or valine intake was associated with 54% (95%CI = 29%, 70%, P = 0.001), 64% (95%CI = 29%, 82%, P = 0.003), or 54% (95%CI = 1%, 79%, P = 0.049) decrease in the risk of CVD, respectively. Whole grains, starchy vegetables, mushrooms, fruit, eggs, and dairy and dairy product-derived BCAA were found to attenuate CVD risk (P ranged: = 0.002–0.027).ConclusionHigher BCAA intake, in particular leucine and valine, might be associated with a lower risk of CVD. |
| first_indexed | 2024-04-12T13:35:12Z |
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| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-12T13:35:12Z |
| publishDate | 2022-10-01 |
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| spelling | doaj.art-fe65af552ae74e9aa939722ebf33f8ee2022-12-22T03:31:02ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-10-01910.3389/fnut.2022.999189999189The association between dietary branched-chain amino acids and the risk of cardiovascular diseases in Chinese patients with type 2 diabetes: A hospital-based case–control studyLu Zheng0Jun Cai1Yong-hui Feng2Xin Su3Shi-yun Chen4Jia-zi Liu5Wan-lin Li6Rui-qing Ouyang7Jun-rong Ma8Chen Cheng9Ying-jun Mu10Shi-wen Zhang11Kai-yin He12Fang-fang Zeng13Yan-bin Ye14Yan-bin Ye15Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, ChinaDepartment of Clinical Nutrition, The First Affiliated Hospital, Jinan University, Guangzhou, ChinaDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, ChinaDepartment of Clinical Nutrition, The First Affiliated Hospital, Jinan University, Guangzhou, ChinaDepartment of Clinical Nutrition, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaBackgroundPrevious studies showed conflicting evidence on the association between the intake of dietary branched-chain amino acid (BCAA) and the risk of cardiovascular disease (CVD). However, this relationship has not been studied in patients with type 2 diabetes. Therefore, we evaluated the effects of total and individual dietary BCAA (leucine, isoleucine, and valine) intake on CVD risk among individuals with type 2 diabetes in China.Materials and methodsA total of 419 patients with type 2 diabetes who have been diagnosed with CVD (within 2 weeks) were recruited between March 2013 and September 2015 in China. Cases with CVD were 1:1 matched to controls with type 2 diabetes but without CVD by age (±5 years) and sex. A validated 79-item semiquantitative food frequency questionnaire (FFQ) was administered to assess the participants' dietary data. Total dietary BCAA per individual was the summation of the daily intake of isoleucine, leucine, and valine. OR and corresponding CIs were computed by conditional logistic regression models adjusted for potential confounders.ResultsMedian values of the daily intake of total BCAA were 11.87 g, with an interquartile range of 10.46–13.15 g for cases, and 12.47 g, with an interquartile range of 11.08–13.79 g for controls (P = 0.001). Dietary BCAA was inversely related to CVD risk after multivariable adjustment (OR Q4−Q1 = 0.23, 95%CI = 0.10, 0.51, P trend <0.001 for total BCAA; OR Q4−Q1 = 0.20, 95%CI = 0.07, 0.53, P trend = 0.001 for leucine). For each 1-S.D. increase in total dietary BCAA, leucine or valine intake was associated with 54% (95%CI = 29%, 70%, P = 0.001), 64% (95%CI = 29%, 82%, P = 0.003), or 54% (95%CI = 1%, 79%, P = 0.049) decrease in the risk of CVD, respectively. Whole grains, starchy vegetables, mushrooms, fruit, eggs, and dairy and dairy product-derived BCAA were found to attenuate CVD risk (P ranged: = 0.002–0.027).ConclusionHigher BCAA intake, in particular leucine and valine, might be associated with a lower risk of CVD.https://www.frontiersin.org/articles/10.3389/fnut.2022.999189/fullbranched-chain amino acidsBCAAisoleucineleucinevalinecardiovascular diseases |
| spellingShingle | Lu Zheng Jun Cai Yong-hui Feng Xin Su Shi-yun Chen Jia-zi Liu Wan-lin Li Rui-qing Ouyang Jun-rong Ma Chen Cheng Ying-jun Mu Shi-wen Zhang Kai-yin He Fang-fang Zeng Yan-bin Ye Yan-bin Ye The association between dietary branched-chain amino acids and the risk of cardiovascular diseases in Chinese patients with type 2 diabetes: A hospital-based case–control study Frontiers in Nutrition branched-chain amino acids BCAA isoleucine leucine valine cardiovascular diseases |
| title | The association between dietary branched-chain amino acids and the risk of cardiovascular diseases in Chinese patients with type 2 diabetes: A hospital-based case–control study |
| title_full | The association between dietary branched-chain amino acids and the risk of cardiovascular diseases in Chinese patients with type 2 diabetes: A hospital-based case–control study |
| title_fullStr | The association between dietary branched-chain amino acids and the risk of cardiovascular diseases in Chinese patients with type 2 diabetes: A hospital-based case–control study |
| title_full_unstemmed | The association between dietary branched-chain amino acids and the risk of cardiovascular diseases in Chinese patients with type 2 diabetes: A hospital-based case–control study |
| title_short | The association between dietary branched-chain amino acids and the risk of cardiovascular diseases in Chinese patients with type 2 diabetes: A hospital-based case–control study |
| title_sort | association between dietary branched chain amino acids and the risk of cardiovascular diseases in chinese patients with type 2 diabetes a hospital based case control study |
| topic | branched-chain amino acids BCAA isoleucine leucine valine cardiovascular diseases |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.999189/full |
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