Bioactivity of some divalent M(II) complexes of penicillin based Schiff base ligand: Synthesis, spectroscopic characterization, and thermal study
A series of four novel metal complexes of Co(II), Ni(II), Cu(II) and Zn(II) were synthesized from Schiff base derived from amoxicillin (AMX) and picolinaldehyde (PC2). The ligand and metal complexes were fully characterized by physical and spectral techniques such as elemental microanalysis, conduct...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-07-01
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| Series: | Journal of Saudi Chemical Society |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610317301230 |
| _version_ | 1819204979605372928 |
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| author | N.K. Chaudhary P. Mishra |
| author_facet | N.K. Chaudhary P. Mishra |
| author_sort | N.K. Chaudhary |
| collection | DOAJ |
| description | A series of four novel metal complexes of Co(II), Ni(II), Cu(II) and Zn(II) were synthesized from Schiff base derived from amoxicillin (AMX) and picolinaldehyde (PC2). The ligand and metal complexes were fully characterized by physical and spectral techniques such as elemental microanalysis, conductivity, FT-IR, 1H & 13C NMR, UV–vis, mass spectra, EPR, magnetic moment measurement, TGA/DTA, PXRD and antibacterial activity study. The spectroscopic study revealed 1:2 metal ligand ratio and coordination sites in the ligand for metal ions were evaluated by analysis of the spectral results. The surface morphology of the complexes was evaluated by SEM analysis. Molar conductivity implies non-electrolytic nature of the complexes. UV–vis. spectral study nicely supports octahedral geometry for Co(II) and Zn(II) complexes and tetrahedral geometry for Cu(II) complex. The kinetic parameters were extracted from Coats-Redfern equation. The PXRD study revealed nano-crystalline nature of Co(II), Ni(II) & Cu(II) complexes and amorphous nature of Zn(II) complex. The proposed geometry of the complexes was optimized by MM2 calculation supported in Cs-ChemOffice Ultra-11 program. The ligand and metal complexes were screened for antibacterial potency against four human pathogenic clinical strains of bacteria and the data revealed their promising antibacterial activity. Keywords: Schiff base metal complexes, Kinetic parameters, Antibacterial activity, Molecular modeling, Penicillin |
| first_indexed | 2024-12-23T04:44:25Z |
| format | Article |
| id | doaj.art-fe69500a044148ee8b765719a7d758e4 |
| institution | Directory Open Access Journal |
| issn | 1319-6103 |
| language | English |
| last_indexed | 2024-12-23T04:44:25Z |
| publishDate | 2018-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj.art-fe69500a044148ee8b765719a7d758e42022-12-21T17:59:42ZengElsevierJournal of Saudi Chemical Society1319-61032018-07-01225601613Bioactivity of some divalent M(II) complexes of penicillin based Schiff base ligand: Synthesis, spectroscopic characterization, and thermal studyN.K. Chaudhary0P. Mishra1Bio-inorganic and Materials Chemistry Research Laboratory, Tribhuvan University, M.M.A.M. Campus, Biratnagar, NepalCorresponding author.; Bio-inorganic and Materials Chemistry Research Laboratory, Tribhuvan University, M.M.A.M. Campus, Biratnagar, NepalA series of four novel metal complexes of Co(II), Ni(II), Cu(II) and Zn(II) were synthesized from Schiff base derived from amoxicillin (AMX) and picolinaldehyde (PC2). The ligand and metal complexes were fully characterized by physical and spectral techniques such as elemental microanalysis, conductivity, FT-IR, 1H & 13C NMR, UV–vis, mass spectra, EPR, magnetic moment measurement, TGA/DTA, PXRD and antibacterial activity study. The spectroscopic study revealed 1:2 metal ligand ratio and coordination sites in the ligand for metal ions were evaluated by analysis of the spectral results. The surface morphology of the complexes was evaluated by SEM analysis. Molar conductivity implies non-electrolytic nature of the complexes. UV–vis. spectral study nicely supports octahedral geometry for Co(II) and Zn(II) complexes and tetrahedral geometry for Cu(II) complex. The kinetic parameters were extracted from Coats-Redfern equation. The PXRD study revealed nano-crystalline nature of Co(II), Ni(II) & Cu(II) complexes and amorphous nature of Zn(II) complex. The proposed geometry of the complexes was optimized by MM2 calculation supported in Cs-ChemOffice Ultra-11 program. The ligand and metal complexes were screened for antibacterial potency against four human pathogenic clinical strains of bacteria and the data revealed their promising antibacterial activity. Keywords: Schiff base metal complexes, Kinetic parameters, Antibacterial activity, Molecular modeling, Penicillinhttp://www.sciencedirect.com/science/article/pii/S1319610317301230 |
| spellingShingle | N.K. Chaudhary P. Mishra Bioactivity of some divalent M(II) complexes of penicillin based Schiff base ligand: Synthesis, spectroscopic characterization, and thermal study Journal of Saudi Chemical Society |
| title | Bioactivity of some divalent M(II) complexes of penicillin based Schiff base ligand: Synthesis, spectroscopic characterization, and thermal study |
| title_full | Bioactivity of some divalent M(II) complexes of penicillin based Schiff base ligand: Synthesis, spectroscopic characterization, and thermal study |
| title_fullStr | Bioactivity of some divalent M(II) complexes of penicillin based Schiff base ligand: Synthesis, spectroscopic characterization, and thermal study |
| title_full_unstemmed | Bioactivity of some divalent M(II) complexes of penicillin based Schiff base ligand: Synthesis, spectroscopic characterization, and thermal study |
| title_short | Bioactivity of some divalent M(II) complexes of penicillin based Schiff base ligand: Synthesis, spectroscopic characterization, and thermal study |
| title_sort | bioactivity of some divalent m ii complexes of penicillin based schiff base ligand synthesis spectroscopic characterization and thermal study |
| url | http://www.sciencedirect.com/science/article/pii/S1319610317301230 |
| work_keys_str_mv | AT nkchaudhary bioactivityofsomedivalentmiicomplexesofpenicillinbasedschiffbaseligandsynthesisspectroscopiccharacterizationandthermalstudy AT pmishra bioactivityofsomedivalentmiicomplexesofpenicillinbasedschiffbaseligandsynthesisspectroscopiccharacterizationandthermalstudy |