Locally Recurrent Rectal Cancer According to a Standardized MRI Classification System: A Systematic Review of the Literature
(1) Background: The classification of locally recurrent rectal cancer (LRRC) is not currently standardized. The aim of this review was to evaluate pelvic LRRC according to the Beyond TME (BTME) classification system and to consider commonly associated primary tumour characteristics. (2) Methods: A s...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/12/3511 |
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| author | Zena Rokan Constantinos Simillis Christos Kontovounisios Brendan Moran Paris Tekkis Gina Brown |
| author_facet | Zena Rokan Constantinos Simillis Christos Kontovounisios Brendan Moran Paris Tekkis Gina Brown |
| author_sort | Zena Rokan |
| collection | DOAJ |
| description | (1) Background: The classification of locally recurrent rectal cancer (LRRC) is not currently standardized. The aim of this review was to evaluate pelvic LRRC according to the Beyond TME (BTME) classification system and to consider commonly associated primary tumour characteristics. (2) Methods: A systematic review of the literature prior to April 2020 was performed through electronic searches of the Science Citation Index Expanded, EMBASE, MEDLINE, and CENTRAL databases. The primary outcome was to assess the location and frequency of previously classified pelvic LRRC and translate this information into the BTME system. Secondary outcomes were assessing primary tumour characteristics. (3) Results: A total of 58 eligible studies classified 4558 sites of LRRC, most commonly found in the central compartment (18%), following anterior resection (44%), in patients with an ‘advanced’ primary tumour (63%) and following neoadjuvant radiotherapy (29%). Most patients also classified had a low rectal primary tumour. The lymph node status of the primary tumour leading to LRRC was comparable, with 52% node positive versus 48% node negative tumours. (4) Conclusions: This review evaluates the largest number of LRRCs to date using a single classification system. It has also highlighted the need for standardized reporting in order to optimise perioperative treatment planning. |
| first_indexed | 2024-03-09T23:26:54Z |
| format | Article |
| id | doaj.art-fe6a0bd44e7847c9a553a8708fadf13a |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T23:26:54Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-fe6a0bd44e7847c9a553a8708fadf13a2023-11-23T17:17:14ZengMDPI AGJournal of Clinical Medicine2077-03832022-06-011112351110.3390/jcm11123511Locally Recurrent Rectal Cancer According to a Standardized MRI Classification System: A Systematic Review of the LiteratureZena Rokan0Constantinos Simillis1Christos Kontovounisios2Brendan Moran3Paris Tekkis4Gina Brown5Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UKDepartment of Surgery and Cancer, Imperial College London, London SW7 2AZ, UKDepartment of Surgery and Cancer, Imperial College London, London SW7 2AZ, UKPelican Cancer Foundation, Basingstoke RG24 9NN, UKDepartment of Surgery and Cancer, Imperial College London, London SW7 2AZ, UKDepartment of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK(1) Background: The classification of locally recurrent rectal cancer (LRRC) is not currently standardized. The aim of this review was to evaluate pelvic LRRC according to the Beyond TME (BTME) classification system and to consider commonly associated primary tumour characteristics. (2) Methods: A systematic review of the literature prior to April 2020 was performed through electronic searches of the Science Citation Index Expanded, EMBASE, MEDLINE, and CENTRAL databases. The primary outcome was to assess the location and frequency of previously classified pelvic LRRC and translate this information into the BTME system. Secondary outcomes were assessing primary tumour characteristics. (3) Results: A total of 58 eligible studies classified 4558 sites of LRRC, most commonly found in the central compartment (18%), following anterior resection (44%), in patients with an ‘advanced’ primary tumour (63%) and following neoadjuvant radiotherapy (29%). Most patients also classified had a low rectal primary tumour. The lymph node status of the primary tumour leading to LRRC was comparable, with 52% node positive versus 48% node negative tumours. (4) Conclusions: This review evaluates the largest number of LRRCs to date using a single classification system. It has also highlighted the need for standardized reporting in order to optimise perioperative treatment planning.https://www.mdpi.com/2077-0383/11/12/3511locally recurrent rectal cancer (LRRC)rectal cancerBTME classification |
| spellingShingle | Zena Rokan Constantinos Simillis Christos Kontovounisios Brendan Moran Paris Tekkis Gina Brown Locally Recurrent Rectal Cancer According to a Standardized MRI Classification System: A Systematic Review of the Literature Journal of Clinical Medicine locally recurrent rectal cancer (LRRC) rectal cancer BTME classification |
| title | Locally Recurrent Rectal Cancer According to a Standardized MRI Classification System: A Systematic Review of the Literature |
| title_full | Locally Recurrent Rectal Cancer According to a Standardized MRI Classification System: A Systematic Review of the Literature |
| title_fullStr | Locally Recurrent Rectal Cancer According to a Standardized MRI Classification System: A Systematic Review of the Literature |
| title_full_unstemmed | Locally Recurrent Rectal Cancer According to a Standardized MRI Classification System: A Systematic Review of the Literature |
| title_short | Locally Recurrent Rectal Cancer According to a Standardized MRI Classification System: A Systematic Review of the Literature |
| title_sort | locally recurrent rectal cancer according to a standardized mri classification system a systematic review of the literature |
| topic | locally recurrent rectal cancer (LRRC) rectal cancer BTME classification |
| url | https://www.mdpi.com/2077-0383/11/12/3511 |
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