Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

Synaptic dysfunction is increasingly viewed as an early manifestation of Alzheimer's disease (AD), but the cellular mechanism by which β-amyloid (Aβ) may affect synapses remains unclear. Since cultured neurons derived from APP mutant transgenic mice secrete elevated levels of Aβ and parallel th...

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Bibliographic Details
Main Authors: Claudia G. Almeida, Davide Tampellini, Reisuke H. Takahashi, Paul Greengard, Michael T. Lin, Eric M. Snyder, Gunnar K. Gouras
Format: Article
Language:English
Published: Elsevier 2005-11-01
Series:Neurobiology of Disease
Subjects:
Amyloid
Alzheimer
Synapse
Glutamate receptor
Spines
AMPA
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105000720

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