Effect of cyclodextrins on the solubilization of lignoceric acid, ceramide, and cerebroside, and on the enzymatic reactions involving these compounds.
alpha-Cyclodextrin at concentrations of 1–8 mM helps dissolve, in aqueous solution, fatty acids such as lignoceric, stearic, and palmitic, and complex lipids such as ceramide and cerebroside that contain these acids. Formation of an inclusion complex was indicated on examination of the solution by g...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1983-05-01
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| Series: | Journal of Lipid Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520379736 |
| _version_ | 1818590318354759680 |
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| author | I Singh Y Kishimoto |
| author_facet | I Singh Y Kishimoto |
| author_sort | I Singh |
| collection | DOAJ |
| description | alpha-Cyclodextrin at concentrations of 1–8 mM helps dissolve, in aqueous solution, fatty acids such as lignoceric, stearic, and palmitic, and complex lipids such as ceramide and cerebroside that contain these acids. Formation of an inclusion complex was indicated on examination of the solution by gel filtration. alpha-Cyclodextrin strikingly increased synthesis of ceramide from sphingosine and either free lignoceric or stearic acid by rat brain preparations. These results suggest the further use of alpha-cyclodextrin in lipid enzymology, especially in relation to sphingolipid metabolism. |
| first_indexed | 2024-12-16T09:54:38Z |
| format | Article |
| id | doaj.art-fe6f7aac88a142b0ae4cd942f9ea6ada |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-16T09:54:38Z |
| publishDate | 1983-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-fe6f7aac88a142b0ae4cd942f9ea6ada2022-12-21T22:35:58ZengElsevierJournal of Lipid Research0022-22751983-05-01245662665Effect of cyclodextrins on the solubilization of lignoceric acid, ceramide, and cerebroside, and on the enzymatic reactions involving these compounds.I SinghY Kishimotoalpha-Cyclodextrin at concentrations of 1–8 mM helps dissolve, in aqueous solution, fatty acids such as lignoceric, stearic, and palmitic, and complex lipids such as ceramide and cerebroside that contain these acids. Formation of an inclusion complex was indicated on examination of the solution by gel filtration. alpha-Cyclodextrin strikingly increased synthesis of ceramide from sphingosine and either free lignoceric or stearic acid by rat brain preparations. These results suggest the further use of alpha-cyclodextrin in lipid enzymology, especially in relation to sphingolipid metabolism.http://www.sciencedirect.com/science/article/pii/S0022227520379736 |
| spellingShingle | I Singh Y Kishimoto Effect of cyclodextrins on the solubilization of lignoceric acid, ceramide, and cerebroside, and on the enzymatic reactions involving these compounds. Journal of Lipid Research |
| title | Effect of cyclodextrins on the solubilization of lignoceric acid, ceramide, and cerebroside, and on the enzymatic reactions involving these compounds. |
| title_full | Effect of cyclodextrins on the solubilization of lignoceric acid, ceramide, and cerebroside, and on the enzymatic reactions involving these compounds. |
| title_fullStr | Effect of cyclodextrins on the solubilization of lignoceric acid, ceramide, and cerebroside, and on the enzymatic reactions involving these compounds. |
| title_full_unstemmed | Effect of cyclodextrins on the solubilization of lignoceric acid, ceramide, and cerebroside, and on the enzymatic reactions involving these compounds. |
| title_short | Effect of cyclodextrins on the solubilization of lignoceric acid, ceramide, and cerebroside, and on the enzymatic reactions involving these compounds. |
| title_sort | effect of cyclodextrins on the solubilization of lignoceric acid ceramide and cerebroside and on the enzymatic reactions involving these compounds |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520379736 |
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