MicroRNA-222 Regulates Melanoma Plasticity
Melanoma is one of the most aggressive and highly resistant tumors. Cell plasticity in melanoma is one of the main culprits behind its metastatic capabilities. The detailed molecular mechanisms controlling melanoma plasticity are still not completely understood. Here we combine mathematical models o...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-08-01
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| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/9/8/2573 |
| _version_ | 1797559513828556800 |
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| author | Maria Chiara Lionetti Filippo Cola Oleksandr Chepizhko Maria Rita Fumagalli Francesc Font-Clos Roberto Ravasio Saverio Minucci Paola Canzano Marina Camera Guido Tiana Stefano Zapperi Caterina A. M. La Porta |
| author_facet | Maria Chiara Lionetti Filippo Cola Oleksandr Chepizhko Maria Rita Fumagalli Francesc Font-Clos Roberto Ravasio Saverio Minucci Paola Canzano Marina Camera Guido Tiana Stefano Zapperi Caterina A. M. La Porta |
| author_sort | Maria Chiara Lionetti |
| collection | DOAJ |
| description | Melanoma is one of the most aggressive and highly resistant tumors. Cell plasticity in melanoma is one of the main culprits behind its metastatic capabilities. The detailed molecular mechanisms controlling melanoma plasticity are still not completely understood. Here we combine mathematical models of phenotypic switching with experiments on IgR39 human melanoma cells to identify possible key targets to impair phenotypic switching. Our mathematical model shows that a cancer stem cell subpopulation within the tumor prevents phenotypic switching of the other cancer cells. Experiments reveal that hsa-mir-222 is a key factor enabling this process. Our results shed new light on melanoma plasticity, providing a potential target and guidance for therapeutic studies. |
| first_indexed | 2024-03-10T17:46:28Z |
| format | Article |
| id | doaj.art-fe70d9ba882d4bcd8ef66ad79a7ed065 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T17:46:28Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-fe70d9ba882d4bcd8ef66ad79a7ed0652023-11-20T09:32:13ZengMDPI AGJournal of Clinical Medicine2077-03832020-08-0198257310.3390/jcm9082573MicroRNA-222 Regulates Melanoma PlasticityMaria Chiara Lionetti0Filippo Cola1Oleksandr Chepizhko2Maria Rita Fumagalli3Francesc Font-Clos4Roberto Ravasio5Saverio Minucci6Paola Canzano7Marina Camera8Guido Tiana9Stefano Zapperi10Caterina A. M. La Porta11Center for Complexity and Biosystems, Department of Environmental Science and Policy, University of Milan, via Celoria 26, 20133 Milano, ItalyCenter for Complexity and Biosystems, Department of Physics, University of Milan, via Celoria 16, 20133 Milano, ItalyInstitut für Theoretische Physik, Leopold-Franzens-Universität Innsbruck, Technikerstrasse 21a, A-6020 Innsbruck, AustriaCenter for Complexity and Biosystems, Department of Environmental Science and Policy, University of Milan, via Celoria 26, 20133 Milano, ItalyCenter for Complexity and Biosystems, Department of Physics, University of Milan, via Celoria 16, 20133 Milano, ItalyDepartment of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milano, ItalyDepartment of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milano, ItalyCentro Cardiologico Monzino I.R.C.C.S., Via Carlo Parea 4, 20138 Milano, ItalyCentro Cardiologico Monzino I.R.C.C.S., Via Carlo Parea 4, 20138 Milano, ItalyCenter for Complexity and Biosystems, Department of Physics, University of Milan, via Celoria 16, 20133 Milano, ItalyCenter for Complexity and Biosystems, Department of Physics, University of Milan, via Celoria 16, 20133 Milano, ItalyCenter for Complexity and Biosystems, Department of Environmental Science and Policy, University of Milan, via Celoria 26, 20133 Milano, ItalyMelanoma is one of the most aggressive and highly resistant tumors. Cell plasticity in melanoma is one of the main culprits behind its metastatic capabilities. The detailed molecular mechanisms controlling melanoma plasticity are still not completely understood. Here we combine mathematical models of phenotypic switching with experiments on IgR39 human melanoma cells to identify possible key targets to impair phenotypic switching. Our mathematical model shows that a cancer stem cell subpopulation within the tumor prevents phenotypic switching of the other cancer cells. Experiments reveal that hsa-mir-222 is a key factor enabling this process. Our results shed new light on melanoma plasticity, providing a potential target and guidance for therapeutic studies.https://www.mdpi.com/2077-0383/9/8/2573melanomatumor plasticityhsa-mir-222reaction diffusionkinetic equationscancer stem cells |
| spellingShingle | Maria Chiara Lionetti Filippo Cola Oleksandr Chepizhko Maria Rita Fumagalli Francesc Font-Clos Roberto Ravasio Saverio Minucci Paola Canzano Marina Camera Guido Tiana Stefano Zapperi Caterina A. M. La Porta MicroRNA-222 Regulates Melanoma Plasticity Journal of Clinical Medicine melanoma tumor plasticity hsa-mir-222 reaction diffusion kinetic equations cancer stem cells |
| title | MicroRNA-222 Regulates Melanoma Plasticity |
| title_full | MicroRNA-222 Regulates Melanoma Plasticity |
| title_fullStr | MicroRNA-222 Regulates Melanoma Plasticity |
| title_full_unstemmed | MicroRNA-222 Regulates Melanoma Plasticity |
| title_short | MicroRNA-222 Regulates Melanoma Plasticity |
| title_sort | microrna 222 regulates melanoma plasticity |
| topic | melanoma tumor plasticity hsa-mir-222 reaction diffusion kinetic equations cancer stem cells |
| url | https://www.mdpi.com/2077-0383/9/8/2573 |
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