Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A<sub>2A</sub> receptor-dependent manner: A<sub>2A</sub> receptor blockade prevents BDNF release and proliferation of microglia

Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A<sub>2A</sub> receptor-dependent manner: A<sub>2A</sub> receptor blockade prevents BDNF release and proliferation of microglia

<p>Abstract</p> <p>Background</p> <p>Brain-derived neurotrophic factor (BDNF) has been shown to control microglial responses in neuropathic pain. Since adenosine A<sub>2A</sub> receptors (A<sub>2A</sub>Rs) control neuroinflammation, as well as th...

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Bibliographic Details
Main Authors: Gomes Catarina, Ferreira Raquel, George Jimmy, Sanches Rui, Rodrigues Diana I, Gonçalves Nélio, Cunha Rodrigo A
Format: Article
Language:English
Published: BMC 2013-01-01
Series:Journal of Neuroinflammation
Subjects:
Adenosine A<sub>2A</sub> receptors
Neuroinflammation
Microglia
BDNF
Online Access:http://www.jneuroinflammation.com/content/10/1/16

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