Association of bone fracture type and degree of callus formation with leptin concentration in children with long bone fractures
Background/Aim. Recent studies indicate that adipokines have an important role in bone physiology and pathology. Recent data indicate that adipokine leptin functions as a regulator of bone growth at multiple levels, systemically and locally. So far, it has been shown that leptin influences bone volu...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Military Health Department, Ministry of Defance, Serbia
2021-01-01
|
| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84501900062P.pdf |
| _version_ | 1818574076694757376 |
|---|---|
| author | Paunović Zoran Stanojević Ivan Abazović Džihan Rakić Mia Stanković Nikola Đukić Mirjana Milutinović Sanja Starčević Srđan Šupić Gordana Vojvodić Danilo Jović Milena Marić Dušan |
| author_facet | Paunović Zoran Stanojević Ivan Abazović Džihan Rakić Mia Stanković Nikola Đukić Mirjana Milutinović Sanja Starčević Srđan Šupić Gordana Vojvodić Danilo Jović Milena Marić Dušan |
| author_sort | Paunović Zoran |
| collection | DOAJ |
| description | Background/Aim. Recent studies indicate that adipokines have an important role in bone physiology and pathology. Recent data indicate that adipokine leptin functions as a regulator of bone growth at multiple levels, systemically and locally. So far, it has been shown that leptin influences bone volume and bone mineral density in a population with metabolic and/or hormonal abnormality. Data concerning leptin values in non-obese children with fractures are scarce. Methods. This study included 93 non-obese children with long bone fractures (LBF), 14 children with short bone fractures (SBF), and 19 healthy children. Leptin concentration was determined in two blood samples (day 0 and day 21) and analyzed according to gender, fracture type, anatomical localization of the fracture, fracture topography, callus formation, and the healing outcome. Results. Children with LBF demonstrated significantly increased leptin levels compared to the control group (both day 0/day 21). In the control group, girls had significantly more leptin than boys. Leptin value was significantly influenced by anatomical localization since boys and girls with humerus fracture and girls with femur fracture had the highest average leptin concentration in the initial sample. Boys with incomplete callus formation had the highest leptin concentration (both day 0 /day 21), significantly elevated compared to boys’ samples in the control group, boys’ samples with an intermediary and well-formed callus, and also increased compared to the initial samples of girls with incomplete callus. Better callus formation in girls was associated with an increment of leptin concentrations in the second over the initial sample. Girls with partially and satisfactorily formed callus had significantly increased leptin concentration in the second sample (day 21) compared to the boys’ group. Conclusion. Leptin concentration was significantly increased (both samples) in children with LBF compared to children with SBF and corresponding controls. Leptin concentration was highly influenced by gender. High blood leptin concentrations in boys or low leptin concentrations in girls immediately upon fracture could be used to identify groups of children with incomplete callus formation. |
| first_indexed | 2024-12-15T00:21:38Z |
| format | Article |
| id | doaj.art-fe738757da2b457eadf00dfdca25c248 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 2406-0720 |
| language | English |
| last_indexed | 2024-12-15T00:21:38Z |
| publishDate | 2021-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-fe738757da2b457eadf00dfdca25c2482022-12-21T22:42:17ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502406-07202021-01-0178219220110.2298/VSP190314062P0042-84501900062PAssociation of bone fracture type and degree of callus formation with leptin concentration in children with long bone fracturesPaunović Zoran0Stanojević Ivan1Abazović Džihan2Rakić Mia3Stanković Nikola4Đukić Mirjana5Milutinović Sanja6https://orcid.org/0000-0003-3225-3793Starčević Srđan7Šupić Gordana8Vojvodić Danilo9https://orcid.org/0000-0001-9308-3076Jović Milena10Marić Dušan11Institute for Health Protection of Mother and Child of Serbia “Dr. Vukan Čupić”, Belgrade, SerbiaMilitary Medical Academy, Institute for Medical Research, Belgrade, Serbia + Military Medical Academy, Clinic for Orthopedics and Traumatology, Belgrade, SerbiaEmergency Medical Center of Montenegro, Podgorica, MontenegroUniversity of Nantes, Faculty of Dental Surgery, Nantes, France + University of Belgrade, Institute for Biological Research “Siniša Stanković”, Belgrade, SerbiaInstitute for Health Protection of Mother and Child of Serbia “Dr. Vukan Čupić”, Belgrade, SerbiaFaculty of Pharmacy, Department of Toxicology “Academician Danilo Soldatovićˮ, Belgrade, SerbiaUniversity of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, SerbiaUniversity of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, Serbia + Military Medical Academy, Clinic for Orthopedics and Traumatology, Belgrade, SerbiaMilitary Medical Academy, Institute for Medical Research, Belgrade, Serbia + Military Medical Academy, Clinic for Orthopedics and Traumatology, Belgrade, SerbiaMilitary Medical Academy, Institute for Medical Research, Belgrade, Serbia + Military Medical Academy, Clinic for Orthopedics and Traumatology, Belgrade, SerbiaUniversity of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaBackground/Aim. Recent studies indicate that adipokines have an important role in bone physiology and pathology. Recent data indicate that adipokine leptin functions as a regulator of bone growth at multiple levels, systemically and locally. So far, it has been shown that leptin influences bone volume and bone mineral density in a population with metabolic and/or hormonal abnormality. Data concerning leptin values in non-obese children with fractures are scarce. Methods. This study included 93 non-obese children with long bone fractures (LBF), 14 children with short bone fractures (SBF), and 19 healthy children. Leptin concentration was determined in two blood samples (day 0 and day 21) and analyzed according to gender, fracture type, anatomical localization of the fracture, fracture topography, callus formation, and the healing outcome. Results. Children with LBF demonstrated significantly increased leptin levels compared to the control group (both day 0/day 21). In the control group, girls had significantly more leptin than boys. Leptin value was significantly influenced by anatomical localization since boys and girls with humerus fracture and girls with femur fracture had the highest average leptin concentration in the initial sample. Boys with incomplete callus formation had the highest leptin concentration (both day 0 /day 21), significantly elevated compared to boys’ samples in the control group, boys’ samples with an intermediary and well-formed callus, and also increased compared to the initial samples of girls with incomplete callus. Better callus formation in girls was associated with an increment of leptin concentrations in the second over the initial sample. Girls with partially and satisfactorily formed callus had significantly increased leptin concentration in the second sample (day 21) compared to the boys’ group. Conclusion. Leptin concentration was significantly increased (both samples) in children with LBF compared to children with SBF and corresponding controls. Leptin concentration was highly influenced by gender. High blood leptin concentrations in boys or low leptin concentrations in girls immediately upon fracture could be used to identify groups of children with incomplete callus formation.http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84501900062P.pdffractures, bonehumeral fracturesradius fracturestibial fracturesulna fractureschildleptinbony callusgenderprognosis |
| spellingShingle | Paunović Zoran Stanojević Ivan Abazović Džihan Rakić Mia Stanković Nikola Đukić Mirjana Milutinović Sanja Starčević Srđan Šupić Gordana Vojvodić Danilo Jović Milena Marić Dušan Association of bone fracture type and degree of callus formation with leptin concentration in children with long bone fractures Vojnosanitetski Pregled fractures, bone humeral fractures radius fractures tibial fractures ulna fractures child leptin bony callus gender prognosis |
| title | Association of bone fracture type and degree of callus formation with leptin concentration in children with long bone fractures |
| title_full | Association of bone fracture type and degree of callus formation with leptin concentration in children with long bone fractures |
| title_fullStr | Association of bone fracture type and degree of callus formation with leptin concentration in children with long bone fractures |
| title_full_unstemmed | Association of bone fracture type and degree of callus formation with leptin concentration in children with long bone fractures |
| title_short | Association of bone fracture type and degree of callus formation with leptin concentration in children with long bone fractures |
| title_sort | association of bone fracture type and degree of callus formation with leptin concentration in children with long bone fractures |
| topic | fractures, bone humeral fractures radius fractures tibial fractures ulna fractures child leptin bony callus gender prognosis |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84501900062P.pdf |
| work_keys_str_mv | AT paunoviczoran associationofbonefracturetypeanddegreeofcallusformationwithleptinconcentrationinchildrenwithlongbonefractures AT stanojevicivan associationofbonefracturetypeanddegreeofcallusformationwithleptinconcentrationinchildrenwithlongbonefractures AT abazovicdzihan associationofbonefracturetypeanddegreeofcallusformationwithleptinconcentrationinchildrenwithlongbonefractures AT rakicmia associationofbonefracturetypeanddegreeofcallusformationwithleptinconcentrationinchildrenwithlongbonefractures AT stankovicnikola associationofbonefracturetypeanddegreeofcallusformationwithleptinconcentrationinchildrenwithlongbonefractures AT đukicmirjana associationofbonefracturetypeanddegreeofcallusformationwithleptinconcentrationinchildrenwithlongbonefractures AT milutinovicsanja associationofbonefracturetypeanddegreeofcallusformationwithleptinconcentrationinchildrenwithlongbonefractures AT starcevicsrđan associationofbonefracturetypeanddegreeofcallusformationwithleptinconcentrationinchildrenwithlongbonefractures AT supicgordana associationofbonefracturetypeanddegreeofcallusformationwithleptinconcentrationinchildrenwithlongbonefractures AT vojvodicdanilo associationofbonefracturetypeanddegreeofcallusformationwithleptinconcentrationinchildrenwithlongbonefractures AT jovicmilena associationofbonefracturetypeanddegreeofcallusformationwithleptinconcentrationinchildrenwithlongbonefractures AT maricdusan associationofbonefracturetypeanddegreeofcallusformationwithleptinconcentrationinchildrenwithlongbonefractures |