Effect of Silymarin Supplementation in Lung and Liver Histological Modifications during Exercise Training in a Rodent Model
Background: Exercise training induces adaptive physiological and morphological modifications in the entire organism; however, excessive loads of training may increase damage in tissues. The purpose of this study was to evaluate the effect of silymarin in lung and liver histological changes in rats s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Journal of Functional Morphology and Kinesiology |
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| Online Access: | https://www.mdpi.com/2411-5142/6/3/72 |
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| author | Nancy Vargas-Mendoza Marcelo Angeles-Valencia Ángel Morales-González Mauricio Morales-Martínez Eduardo Madrigal-Bujaidar Isela Álvarez-González Tomás Fregoso-Aguilar Luis Delgado-Olivares Eduardo Osiris Madrigal-Santillán José A. Morales-González |
| author_facet | Nancy Vargas-Mendoza Marcelo Angeles-Valencia Ángel Morales-González Mauricio Morales-Martínez Eduardo Madrigal-Bujaidar Isela Álvarez-González Tomás Fregoso-Aguilar Luis Delgado-Olivares Eduardo Osiris Madrigal-Santillán José A. Morales-González |
| author_sort | Nancy Vargas-Mendoza |
| collection | DOAJ |
| description | Background: Exercise training induces adaptive physiological and morphological modifications in the entire organism; however, excessive loads of training may increase damage in tissues. The purpose of this study was to evaluate the effect of silymarin in lung and liver histological changes in rats subjected to exercise training (ET). Methods: Male Wistar rats were subjected to an 8-week ET treadmill program 5 days per week, 60 min/session, and were previously administered 100 mg ascorbic acid or 100 mg of silymarin. Results: Silymarin increased alveolar and bronchial muscle size, improve vascularization, and reduced tissue inflammation. In liver, silymarin promoted the reduction of lipid content. Conclusion: Silymarin supplementation may improve inflammation in pulmonary tissue after 8 weeks of the ET treadmill program, improve cell recovery, and reduce intrahepatic lipid content. |
| first_indexed | 2024-03-10T07:33:27Z |
| format | Article |
| id | doaj.art-fe738f0aaa384788ad30cd0a8caa6f7f |
| institution | Directory Open Access Journal |
| issn | 2411-5142 |
| language | English |
| last_indexed | 2024-03-10T07:33:27Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Morphology and Kinesiology |
| spelling | doaj.art-fe738f0aaa384788ad30cd0a8caa6f7f2023-11-22T13:43:44ZengMDPI AGJournal of Functional Morphology and Kinesiology2411-51422021-08-01637210.3390/jfmk6030072Effect of Silymarin Supplementation in Lung and Liver Histological Modifications during Exercise Training in a Rodent ModelNancy Vargas-Mendoza0Marcelo Angeles-Valencia1Ángel Morales-González2Mauricio Morales-Martínez3Eduardo Madrigal-Bujaidar4Isela Álvarez-González5Tomás Fregoso-Aguilar6Luis Delgado-Olivares7Eduardo Osiris Madrigal-Santillán8José A. Morales-González9Laboratorio de Medicina de Conservación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Col. Casco de Santo Tomás, Del. Miguel Hidalgo, Ciudad de México 11340, MexicoLaboratorio de Medicina de Conservación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Col. Casco de Santo Tomás, Del. Miguel Hidalgo, Ciudad de México 11340, MexicoEscuela Superior de Cómputo, Instituto Politécnico Nacional, Av. Juan de Dios Bátiz s/n Esquina Miguel Othón de Mendizabal, Unidad Profesional Adolfo López Mateos, Ciudad de México 07738, MexicoLicenciatura en Nutrición, Universidad Intercontinental, Insurgentes Sur 4303, Santa Úrsula Xitla, Alcaldía Tlalpan, Ciudad de México 14420, MexicoLaboratorio de Genética, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Unidad Profesional A. López Mateos, Av. Wilfrido Massieu, Col., Lindavista, Ciudad de México 07738, MexicoLaboratorio de Genética, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Unidad Profesional A. López Mateos, Av. Wilfrido Massieu, Col., Lindavista, Ciudad de México 07738, MexicoLaboratorio de Hormonas y Conducta, Departamento de Fisiología, ENCB Campus Zacatenco, Instituto Politécnico Nacional, Ciudad de México 07700, MexicoCentro de Investigación Interdisciplinario, Área Académica de Nutrición, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Circuito Actopan-Tilcuauttla, s/n, Ex Hacienda La Concepción, San Agustín Tlaxiaca 42160, Hidalgo, MexicoLaboratorio de Medicina de Conservación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Col. Casco de Santo Tomás, Del. Miguel Hidalgo, Ciudad de México 11340, MexicoLaboratorio de Medicina de Conservación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Col. Casco de Santo Tomás, Del. Miguel Hidalgo, Ciudad de México 11340, MexicoBackground: Exercise training induces adaptive physiological and morphological modifications in the entire organism; however, excessive loads of training may increase damage in tissues. The purpose of this study was to evaluate the effect of silymarin in lung and liver histological changes in rats subjected to exercise training (ET). Methods: Male Wistar rats were subjected to an 8-week ET treadmill program 5 days per week, 60 min/session, and were previously administered 100 mg ascorbic acid or 100 mg of silymarin. Results: Silymarin increased alveolar and bronchial muscle size, improve vascularization, and reduced tissue inflammation. In liver, silymarin promoted the reduction of lipid content. Conclusion: Silymarin supplementation may improve inflammation in pulmonary tissue after 8 weeks of the ET treadmill program, improve cell recovery, and reduce intrahepatic lipid content.https://www.mdpi.com/2411-5142/6/3/72exercise trainingsilymarinlungliverhistological changesinflammation |
| spellingShingle | Nancy Vargas-Mendoza Marcelo Angeles-Valencia Ángel Morales-González Mauricio Morales-Martínez Eduardo Madrigal-Bujaidar Isela Álvarez-González Tomás Fregoso-Aguilar Luis Delgado-Olivares Eduardo Osiris Madrigal-Santillán José A. Morales-González Effect of Silymarin Supplementation in Lung and Liver Histological Modifications during Exercise Training in a Rodent Model Journal of Functional Morphology and Kinesiology exercise training silymarin lung liver histological changes inflammation |
| title | Effect of Silymarin Supplementation in Lung and Liver Histological Modifications during Exercise Training in a Rodent Model |
| title_full | Effect of Silymarin Supplementation in Lung and Liver Histological Modifications during Exercise Training in a Rodent Model |
| title_fullStr | Effect of Silymarin Supplementation in Lung and Liver Histological Modifications during Exercise Training in a Rodent Model |
| title_full_unstemmed | Effect of Silymarin Supplementation in Lung and Liver Histological Modifications during Exercise Training in a Rodent Model |
| title_short | Effect of Silymarin Supplementation in Lung and Liver Histological Modifications during Exercise Training in a Rodent Model |
| title_sort | effect of silymarin supplementation in lung and liver histological modifications during exercise training in a rodent model |
| topic | exercise training silymarin lung liver histological changes inflammation |
| url | https://www.mdpi.com/2411-5142/6/3/72 |
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