Naturally Occurring Antioxidant Therapy in Alzheimer’s Disease
It is estimated that the prevalence rate of Alzheimer’s disease (AD) will double by the year 2040. Although currently available treatments help with symptom management, they do not prevent, delay the progression of, or cure the disease. Interestingly, a shared characteristic of AD and other neurodeg...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/2/213 |
| _version_ | 1797483373747240960 |
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| author | Andrila E. Collins Tarek M. Saleh Bettina E. Kalisch |
| author_facet | Andrila E. Collins Tarek M. Saleh Bettina E. Kalisch |
| author_sort | Andrila E. Collins |
| collection | DOAJ |
| description | It is estimated that the prevalence rate of Alzheimer’s disease (AD) will double by the year 2040. Although currently available treatments help with symptom management, they do not prevent, delay the progression of, or cure the disease. Interestingly, a shared characteristic of AD and other neurodegenerative diseases and disorders is oxidative stress. Despite profound evidence supporting the role of oxidative stress in the pathogenesis and progression of AD, none of the currently available treatment options address oxidative stress. Recently, attention has been placed on the use of antioxidants to mitigate the effects of oxidative stress in the central nervous system. In preclinical studies utilizing cellular and animal models, natural antioxidants showed therapeutic promise when administered alone or in combination with other compounds. More recently, the concept of combination antioxidant therapy has been explored as a novel approach to preventing and treating neurodegenerative conditions that present with oxidative stress as a contributing factor. In this review, the relationship between oxidative stress and AD pathology and the neuroprotective role of natural antioxidants from natural sources are discussed. Additionally, the therapeutic potential of natural antioxidants as preventatives and/or treatment for AD is examined, with special attention paid to natural antioxidant combinations and conjugates that are currently being investigated in human clinical trials. |
| first_indexed | 2024-03-09T22:46:02Z |
| format | Article |
| id | doaj.art-fe75e4a7858040f0bb988a60dffa4547 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T22:46:02Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-fe75e4a7858040f0bb988a60dffa45472023-11-23T18:30:11ZengMDPI AGAntioxidants2076-39212022-01-0111221310.3390/antiox11020213Naturally Occurring Antioxidant Therapy in Alzheimer’s DiseaseAndrila E. Collins0Tarek M. Saleh1Bettina E. Kalisch2Department of Biomedical Sciences and Collaborative Specialization in Neuroscience Program, University of Guelph, Guelph, ON N1G 2W1, CanadaDepartment of Biomedical Sciences and Collaborative Specialization in Neuroscience Program, University of Guelph, Guelph, ON N1G 2W1, CanadaDepartment of Biomedical Sciences and Collaborative Specialization in Neuroscience Program, University of Guelph, Guelph, ON N1G 2W1, CanadaIt is estimated that the prevalence rate of Alzheimer’s disease (AD) will double by the year 2040. Although currently available treatments help with symptom management, they do not prevent, delay the progression of, or cure the disease. Interestingly, a shared characteristic of AD and other neurodegenerative diseases and disorders is oxidative stress. Despite profound evidence supporting the role of oxidative stress in the pathogenesis and progression of AD, none of the currently available treatment options address oxidative stress. Recently, attention has been placed on the use of antioxidants to mitigate the effects of oxidative stress in the central nervous system. In preclinical studies utilizing cellular and animal models, natural antioxidants showed therapeutic promise when administered alone or in combination with other compounds. More recently, the concept of combination antioxidant therapy has been explored as a novel approach to preventing and treating neurodegenerative conditions that present with oxidative stress as a contributing factor. In this review, the relationship between oxidative stress and AD pathology and the neuroprotective role of natural antioxidants from natural sources are discussed. Additionally, the therapeutic potential of natural antioxidants as preventatives and/or treatment for AD is examined, with special attention paid to natural antioxidant combinations and conjugates that are currently being investigated in human clinical trials.https://www.mdpi.com/2076-3921/11/2/213antioxidantsoxidative stressamyloid-betaAlzheimer’s diseaseclinical trials |
| spellingShingle | Andrila E. Collins Tarek M. Saleh Bettina E. Kalisch Naturally Occurring Antioxidant Therapy in Alzheimer’s Disease Antioxidants antioxidants oxidative stress amyloid-beta Alzheimer’s disease clinical trials |
| title | Naturally Occurring Antioxidant Therapy in Alzheimer’s Disease |
| title_full | Naturally Occurring Antioxidant Therapy in Alzheimer’s Disease |
| title_fullStr | Naturally Occurring Antioxidant Therapy in Alzheimer’s Disease |
| title_full_unstemmed | Naturally Occurring Antioxidant Therapy in Alzheimer’s Disease |
| title_short | Naturally Occurring Antioxidant Therapy in Alzheimer’s Disease |
| title_sort | naturally occurring antioxidant therapy in alzheimer s disease |
| topic | antioxidants oxidative stress amyloid-beta Alzheimer’s disease clinical trials |
| url | https://www.mdpi.com/2076-3921/11/2/213 |
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