Ferlin Overview: From Membrane to Cancer Biology
In mammal myocytes, endothelial cells and inner ear cells, ferlins are proteins involved in membrane processes such as fusion, recycling, endo- and exocytosis. They harbour several C2 domains allowing their interaction with phospholipids. The expression of several Ferlin genes was described as alter...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/9/954 |
| _version_ | 1797709045310685184 |
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| author | Olivier Peulen Gilles Rademaker Sandy Anania Andrei Turtoi Akeila Bellahcène Vincent Castronovo |
| author_facet | Olivier Peulen Gilles Rademaker Sandy Anania Andrei Turtoi Akeila Bellahcène Vincent Castronovo |
| author_sort | Olivier Peulen |
| collection | DOAJ |
| description | In mammal myocytes, endothelial cells and inner ear cells, ferlins are proteins involved in membrane processes such as fusion, recycling, endo- and exocytosis. They harbour several C2 domains allowing their interaction with phospholipids. The expression of several Ferlin genes was described as altered in several tumoural tissues. Intriguingly, beyond a simple alteration, myoferlin, otoferlin and Fer1L4 expressions were negatively correlated with patient survival in some cancer types. Therefore, it can be assumed that membrane biology is of extreme importance for cell survival and signalling, making Ferlin proteins core machinery indispensable for cancer cell adaptation to hostile environments. The evidences suggest that myoferlin, when overexpressed, enhances cancer cell proliferation, migration and metabolism by affecting various aspects of membrane biology. Targeting myoferlin using pharmacological compounds, gene transfer technology, or interfering RNA is now considered as an emerging therapeutic strategy. |
| first_indexed | 2024-03-12T06:31:38Z |
| format | Article |
| id | doaj.art-fe768a5642f145a4a22db5b65e2322e4 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T06:31:38Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-fe768a5642f145a4a22db5b65e2322e42023-09-03T01:38:11ZengMDPI AGCells2073-44092019-08-018995410.3390/cells8090954cells8090954Ferlin Overview: From Membrane to Cancer BiologyOlivier Peulen0Gilles Rademaker1Sandy Anania2Andrei Turtoi3Akeila Bellahcène4Vincent Castronovo5Metastasis Research Laboratory, Giga Cancer, University of Liège, B4000 Liège, BelgiumMetastasis Research Laboratory, Giga Cancer, University of Liège, B4000 Liège, BelgiumMetastasis Research Laboratory, Giga Cancer, University of Liège, B4000 Liège, BelgiumTumor Microenvironment Laboratory, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, 34000 Montpellier, FranceMetastasis Research Laboratory, Giga Cancer, University of Liège, B4000 Liège, BelgiumMetastasis Research Laboratory, Giga Cancer, University of Liège, B4000 Liège, BelgiumIn mammal myocytes, endothelial cells and inner ear cells, ferlins are proteins involved in membrane processes such as fusion, recycling, endo- and exocytosis. They harbour several C2 domains allowing their interaction with phospholipids. The expression of several Ferlin genes was described as altered in several tumoural tissues. Intriguingly, beyond a simple alteration, myoferlin, otoferlin and Fer1L4 expressions were negatively correlated with patient survival in some cancer types. Therefore, it can be assumed that membrane biology is of extreme importance for cell survival and signalling, making Ferlin proteins core machinery indispensable for cancer cell adaptation to hostile environments. The evidences suggest that myoferlin, when overexpressed, enhances cancer cell proliferation, migration and metabolism by affecting various aspects of membrane biology. Targeting myoferlin using pharmacological compounds, gene transfer technology, or interfering RNA is now considered as an emerging therapeutic strategy.https://www.mdpi.com/2073-4409/8/9/954ferlinmyoferlindysferlinotoferlinC2 domainplasma membrane |
| spellingShingle | Olivier Peulen Gilles Rademaker Sandy Anania Andrei Turtoi Akeila Bellahcène Vincent Castronovo Ferlin Overview: From Membrane to Cancer Biology Cells ferlin myoferlin dysferlin otoferlin C2 domain plasma membrane |
| title | Ferlin Overview: From Membrane to Cancer Biology |
| title_full | Ferlin Overview: From Membrane to Cancer Biology |
| title_fullStr | Ferlin Overview: From Membrane to Cancer Biology |
| title_full_unstemmed | Ferlin Overview: From Membrane to Cancer Biology |
| title_short | Ferlin Overview: From Membrane to Cancer Biology |
| title_sort | ferlin overview from membrane to cancer biology |
| topic | ferlin myoferlin dysferlin otoferlin C2 domain plasma membrane |
| url | https://www.mdpi.com/2073-4409/8/9/954 |
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