Molecular Mechanisms Associated with ROR1-Mediated Drug Resistance: Crosstalk with Hippo-YAP/TAZ and BMI-1 Pathways

Molecular Mechanisms Associated with ROR1-Mediated Drug Resistance: Crosstalk with Hippo-YAP/TAZ and BMI-1 Pathways

Signaling via the Wnt-related receptor tyrosine kinase-like orphan receptor 1 (ROR1) triggers tumorigenic features associated with cancer stem cells (CSCs) and epithelial−mesenchymal transition (EMT), while aberrant expression of ROR1 is strongly linked to advanced disease progression and...

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Bibliographic Details
Main Authors: Hanna Karvonen, Harlan Barker, Laura Kaleva, Wilhelmiina Niininen, Daniela Ungureanu
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cells
Subjects:
Wnt signaling
ROR1
Wnt5a
Hippo-YAP/TAZ
BMI-1
drug resistance
cancer stem cells
stemness
Online Access:https://www.mdpi.com/2073-4409/8/8/812

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