APOE genotype and age modifies the correlation between cognitive status and metabolites from hippocampus by a 2D 1H-MRS in non-demented elders

APOE genotype and age modifies the correlation between cognitive status and metabolites from hippocampus by a 2D 1H-MRS in non-demented elders

Purpose. To examine the associations among age, Apolipoprotein E (APOE) genotype, metabolic changes in the hippocampus detected by 2D 1H magnetic resonance spectroscopy (MRS), and neuropsychological measures of cognition in non-demented elders.Materials and Methods. We studied a cohort of 16 cogniti...

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Bibliographic Details
Main Authors: Zhenyu Yin, Wenbo Wu, Renyuan Liu, Xue Liang, Tingting Yu, Xiaoling Chen, Jie Feng, Aibin Guo, Yu Xie, Haiyan Yang, Mingmin Huang, Chuanshuai Tian, Bing Zhang, Yun Xu
Format: Article
Language:English
Published: PeerJ Inc. 2015-09-01
Series:PeerJ
Subjects:
Amnestic mild cognitive impairment
2D1H-MRS metabolites
Hippocampus
APOE genotype
Age
Online Access:https://peerj.com/articles/1202.pdf

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