The Role of Neoantigens in Cancer Immunotherapy
Somatic mutation-derived neoantigens, expressed only on tumor cells, may elicit antitumor T-cell responses in cancer immunotherapies with minimal immune tolerance. Neoantigens can be identified by multiple bioinformatics technologies, mainly based on whole-exome sequencing. Personalized cancer vacci...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.682325/full |
| _version_ | 1818693472568213504 |
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| author | Yueting Zhu Jiyan Liu Jiyan Liu |
| author_facet | Yueting Zhu Jiyan Liu Jiyan Liu |
| author_sort | Yueting Zhu |
| collection | DOAJ |
| description | Somatic mutation-derived neoantigens, expressed only on tumor cells, may elicit antitumor T-cell responses in cancer immunotherapies with minimal immune tolerance. Neoantigens can be identified by multiple bioinformatics technologies, mainly based on whole-exome sequencing. Personalized cancer vaccines and adoptive T cell therapies are two primary treatment modalities targeting neoantigens, and both of them have shown promising therapeutic effects. This review, summarizes the history of neoantigen-related tumor control, introduces recent neoantigen screening and identification methods, and discusses the role of neoantigen in cancer immunotherapies. Moreover, we propose the challenges of targeting neoantigens for cancer treatment. |
| first_indexed | 2024-12-17T13:14:14Z |
| format | Article |
| id | doaj.art-fe79759c04674279be3d10c85e0fa57e |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-17T13:14:14Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-fe79759c04674279be3d10c85e0fa57e2022-12-21T21:47:03ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-08-011110.3389/fonc.2021.682325682325The Role of Neoantigens in Cancer ImmunotherapyYueting Zhu0Jiyan Liu1Jiyan Liu2Department of Biotherapy, Cancer Center, and National Clinical Research Center for Geriatrics, West China Hospital, West China Medical School, Sichuan University, Chengdu, ChinaDepartment of Biotherapy, Cancer Center, and National Clinical Research Center for Geriatrics, West China Hospital, West China Medical School, Sichuan University, Chengdu, ChinaDepartment of Oncology, The First People’s Hospital of Ziyang, Ziyang, ChinaSomatic mutation-derived neoantigens, expressed only on tumor cells, may elicit antitumor T-cell responses in cancer immunotherapies with minimal immune tolerance. Neoantigens can be identified by multiple bioinformatics technologies, mainly based on whole-exome sequencing. Personalized cancer vaccines and adoptive T cell therapies are two primary treatment modalities targeting neoantigens, and both of them have shown promising therapeutic effects. This review, summarizes the history of neoantigen-related tumor control, introduces recent neoantigen screening and identification methods, and discusses the role of neoantigen in cancer immunotherapies. Moreover, we propose the challenges of targeting neoantigens for cancer treatment.https://www.frontiersin.org/articles/10.3389/fonc.2021.682325/fullneoantigenimmunotherapyvaccineadoptive cell therapypersonalized treatment |
| spellingShingle | Yueting Zhu Jiyan Liu Jiyan Liu The Role of Neoantigens in Cancer Immunotherapy Frontiers in Oncology neoantigen immunotherapy vaccine adoptive cell therapy personalized treatment |
| title | The Role of Neoantigens in Cancer Immunotherapy |
| title_full | The Role of Neoantigens in Cancer Immunotherapy |
| title_fullStr | The Role of Neoantigens in Cancer Immunotherapy |
| title_full_unstemmed | The Role of Neoantigens in Cancer Immunotherapy |
| title_short | The Role of Neoantigens in Cancer Immunotherapy |
| title_sort | role of neoantigens in cancer immunotherapy |
| topic | neoantigen immunotherapy vaccine adoptive cell therapy personalized treatment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.682325/full |
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