MMPP promotes adipogenesis and glucose uptake via binding to the PPARγ ligand binding domain in 3T3-L1 MBX cells

MMPP promotes adipogenesis and glucose uptake via binding to the PPARγ ligand binding domain in 3T3-L1 MBX cells

Peroxisome proliferator-activated receptor-gamma (PPARγ) is a transcription factor involved in adipogenesis, and its transcriptional activity depends on its ligands. Thiazolidinediones (TZDs), well-known PPARγ agonists, are drugs that improve insulin resistance in type 2 diabetes. However, TZDs are...

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Bibliographic Details
Main Authors: Na-Yeon Kim, Chae-Min Lim, Hyo-Min Park, Jinju Kim, Thu-Huyen Pham, Young Yang, Hee Pom Lee, Jin Tae Hong, Do-Young Yoon
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
MMPP
PPARγ agonist
type 2 diabetes treatment
adipogenesis
glucose uptake
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.994584/full

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