Metabolic Remodeling in Skeletal Muscle Atrophy as a Therapeutic Target
Skeletal muscle is a highly responsive tissue, able to remodel its size and metabolism in response to external demand. Muscle fibers can vary from fast glycolytic to slow oxidative, and their frequency in a specific muscle is tightly regulated by fiber maturation, innervation, or external causes. At...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
|
| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/11/8/517 |
| _version_ | 1797522958532476928 |
|---|---|
| author | Alessandra Renzini Carles Sánchez Riera Isidora Minic Chiara D’Ercole Biliana Lozanoska-Ochser Alessia Cedola Giuseppe Gigli Viviana Moresi Luca Madaro |
| author_facet | Alessandra Renzini Carles Sánchez Riera Isidora Minic Chiara D’Ercole Biliana Lozanoska-Ochser Alessia Cedola Giuseppe Gigli Viviana Moresi Luca Madaro |
| author_sort | Alessandra Renzini |
| collection | DOAJ |
| description | Skeletal muscle is a highly responsive tissue, able to remodel its size and metabolism in response to external demand. Muscle fibers can vary from fast glycolytic to slow oxidative, and their frequency in a specific muscle is tightly regulated by fiber maturation, innervation, or external causes. Atrophic conditions, including aging, amyotrophic lateral sclerosis, and cancer-induced cachexia, differ in the causative factors and molecular signaling leading to muscle wasting; nevertheless, all of these conditions are characterized by metabolic remodeling, which contributes to the pathological progression of muscle atrophy. Here, we discuss how changes in muscle metabolism can be used as a therapeutic target and review the evidence in support of nutritional interventions and/or physical exercise as tools for counteracting muscle wasting in atrophic conditions. |
| first_indexed | 2024-03-10T08:36:42Z |
| format | Article |
| id | doaj.art-fe7a73b7089346ae97062b86fcc6fbe3 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T08:36:42Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-fe7a73b7089346ae97062b86fcc6fbe32023-11-22T08:39:27ZengMDPI AGMetabolites2218-19892021-08-0111851710.3390/metabo11080517Metabolic Remodeling in Skeletal Muscle Atrophy as a Therapeutic TargetAlessandra Renzini0Carles Sánchez Riera1Isidora Minic2Chiara D’Ercole3Biliana Lozanoska-Ochser4Alessia Cedola5Giuseppe Gigli6Viviana Moresi7Luca Madaro8Unit of Histology and Medical Embryology, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome, 00185 Rome, ItalyUnit of Histology and Medical Embryology, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome, 00185 Rome, ItalyUnit of Histology and Medical Embryology, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome, 00185 Rome, ItalyUnit of Histology and Medical Embryology, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome, 00185 Rome, ItalyUnit of Histology and Medical Embryology, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome, 00185 Rome, ItalyInstitute of Nanotechnology, c/o Dipartimento di Fisica, National Research Council (CNR-NANOTEC), Sapienza University of Rome, 00185 Rome, ItalyInstitute of Nanotechnology, c/o Campus Ecotekne, National Research Council (CNR-NANOTEC), Monteroni, 73100 Lecce, ItalyUnit of Histology and Medical Embryology, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome, 00185 Rome, ItalyUnit of Histology and Medical Embryology, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome, 00185 Rome, ItalySkeletal muscle is a highly responsive tissue, able to remodel its size and metabolism in response to external demand. Muscle fibers can vary from fast glycolytic to slow oxidative, and their frequency in a specific muscle is tightly regulated by fiber maturation, innervation, or external causes. Atrophic conditions, including aging, amyotrophic lateral sclerosis, and cancer-induced cachexia, differ in the causative factors and molecular signaling leading to muscle wasting; nevertheless, all of these conditions are characterized by metabolic remodeling, which contributes to the pathological progression of muscle atrophy. Here, we discuss how changes in muscle metabolism can be used as a therapeutic target and review the evidence in support of nutritional interventions and/or physical exercise as tools for counteracting muscle wasting in atrophic conditions.https://www.mdpi.com/2218-1989/11/8/517skeletal muscle metabolismmuscle wastingphysical exercisedietepigenetics |
| spellingShingle | Alessandra Renzini Carles Sánchez Riera Isidora Minic Chiara D’Ercole Biliana Lozanoska-Ochser Alessia Cedola Giuseppe Gigli Viviana Moresi Luca Madaro Metabolic Remodeling in Skeletal Muscle Atrophy as a Therapeutic Target Metabolites skeletal muscle metabolism muscle wasting physical exercise diet epigenetics |
| title | Metabolic Remodeling in Skeletal Muscle Atrophy as a Therapeutic Target |
| title_full | Metabolic Remodeling in Skeletal Muscle Atrophy as a Therapeutic Target |
| title_fullStr | Metabolic Remodeling in Skeletal Muscle Atrophy as a Therapeutic Target |
| title_full_unstemmed | Metabolic Remodeling in Skeletal Muscle Atrophy as a Therapeutic Target |
| title_short | Metabolic Remodeling in Skeletal Muscle Atrophy as a Therapeutic Target |
| title_sort | metabolic remodeling in skeletal muscle atrophy as a therapeutic target |
| topic | skeletal muscle metabolism muscle wasting physical exercise diet epigenetics |
| url | https://www.mdpi.com/2218-1989/11/8/517 |
| work_keys_str_mv | AT alessandrarenzini metabolicremodelinginskeletalmuscleatrophyasatherapeutictarget AT carlessanchezriera metabolicremodelinginskeletalmuscleatrophyasatherapeutictarget AT isidoraminic metabolicremodelinginskeletalmuscleatrophyasatherapeutictarget AT chiaradercole metabolicremodelinginskeletalmuscleatrophyasatherapeutictarget AT bilianalozanoskaochser metabolicremodelinginskeletalmuscleatrophyasatherapeutictarget AT alessiacedola metabolicremodelinginskeletalmuscleatrophyasatherapeutictarget AT giuseppegigli metabolicremodelinginskeletalmuscleatrophyasatherapeutictarget AT vivianamoresi metabolicremodelinginskeletalmuscleatrophyasatherapeutictarget AT lucamadaro metabolicremodelinginskeletalmuscleatrophyasatherapeutictarget |