TNP Analogues Inhibit the Virulence Promoting IP<sub>3-4</sub> Kinase Arg1 in the Fungal Pathogen <i>Cryptococcus neoformans</i>

TNP Analogues Inhibit the Virulence Promoting IP<sub>3-4</sub> Kinase Arg1 in the Fungal Pathogen <i>Cryptococcus neoformans</i>

New antifungals with unique modes of action are urgently needed to treat the increasing global burden of invasive fungal infections. The fungal inositol polyphosphate kinase (IPK) pathway, comprised of IPKs that convert IP<sub>3</sub> to IP<sub>8</sub>, provides a promising n...

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Bibliographic Details
Main Authors: Desmarini Desmarini, Daniel Truong, Lorna Wilkinson-White, Chandrika Desphande, Mario Torrado, Joel P. Mackay, Jacqueline M. Matthews, Tania C. Sorrell, Sophie Lev, Philip E. Thompson, Julianne Teresa Djordjevic
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Biomolecules
Subjects:
inositol polyphosphate kinase
IP<sub>3-4</sub>K
TNP
dibenzylaminopurine
fungal pathogens
antifungal drug discovery
Online Access:https://www.mdpi.com/2218-273X/12/10/1526

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