Acute Ischemic Stroke in COVID-19: A Case-Based Systematic Review
Corona virus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) is recognized as a global pandemic by WHO 2020 with 5,934 936 infections, 367,166 deaths and affecting over 200 countries as of 30th May 2020. Acute Ischemic Stroke (AIS) in brain is also emerg...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-09-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.01031/full |
| _version_ | 1818930428056174592 |
|---|---|
| author | Tissa Wijeratne Tissa Wijeratne Tissa Wijeratne Carmela Sales Leila Karimi Leila Karimi Sheila Gillard Crewther Sheila Gillard Crewther |
| author_facet | Tissa Wijeratne Tissa Wijeratne Tissa Wijeratne Carmela Sales Leila Karimi Leila Karimi Sheila Gillard Crewther Sheila Gillard Crewther |
| author_sort | Tissa Wijeratne |
| collection | DOAJ |
| description | Corona virus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) is recognized as a global pandemic by WHO 2020 with 5,934 936 infections, 367,166 deaths and affecting over 200 countries as of 30th May 2020. Acute Ischemic Stroke (AIS) in brain is also emerging as an important neurovascular/neurological complication of COVID-19, associated with extreme immune responses leading to dysregulated coagulation system and generalized thrombo-embolic status and increased risk of AIS especially among usually less vulnerable younger adults in this cohort. Thus, in early June 2020, we aimed to review the clinical data on all published cases of COVID-19 and concomitant AIS, with a view to understanding the pertinent clinical, laboratory and imaging features. The neutrophil-lymphocyte ratio (NLR) at time of hospital admission for COVID infection correlates positively with the duration of time before onset of clinical features of AIS. Higher NLR, C-Reactive protein, serum ferritin, D-dimer and fibrinogen levels are associated with poor prognosis of AIS in COVID-19 with 75% of patients dying or being severely disabled at present. Currently it is too early to comment on the long-term outcomes for survivors. |
| first_indexed | 2024-12-20T04:00:32Z |
| format | Article |
| id | doaj.art-fe7b2b2451764a4584d487850678030e |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-20T04:00:32Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-fe7b2b2451764a4584d487850678030e2022-12-21T19:54:11ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-09-011110.3389/fneur.2020.01031573655Acute Ischemic Stroke in COVID-19: A Case-Based Systematic ReviewTissa Wijeratne0Tissa Wijeratne1Tissa Wijeratne2Carmela Sales3Leila Karimi4Leila Karimi5Sheila Gillard Crewther6Sheila Gillard Crewther7Neurology & Stroke, Australian Institute for Musculoskeletal Science, Melbourne Medical School, Sunshine Hospital, The University of Melbourne, Parkville, VIC, AustraliaSchool of Psychology and Public Health, College of Science, Health and Engineering, La Trobe University, Melbourne, Parkville, VIC, AustraliaDepartment of Medicine and Dean's Office, Rajarata University of Sri Lanka, Anuradhapura, Sri LankaDepartment of Neurology, Australian Institute for Musculoskeletal Science, Level Three, Western Centre for Health Research and Education, Sunshine Hospital, Western Health & University Melbourne, St Albans, VIC, AustraliaSchool of Psychology and Public Health, College of Science, Health and Engineering, La Trobe University, Melbourne, Parkville, VIC, AustraliaFaculty of Social and Political Sciences, Tbilisi State University, Tbilisi, GeorgiaSchool of Psychology and Public Health, College of Science, Health and Engineering, La Trobe University, Melbourne, Parkville, VIC, AustraliaDepartment of Neurology, Australian Institute for Musculoskeletal Science, Level Three, Western Centre for Health Research and Education, Sunshine Hospital, Western Health & University Melbourne, St Albans, VIC, AustraliaCorona virus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) is recognized as a global pandemic by WHO 2020 with 5,934 936 infections, 367,166 deaths and affecting over 200 countries as of 30th May 2020. Acute Ischemic Stroke (AIS) in brain is also emerging as an important neurovascular/neurological complication of COVID-19, associated with extreme immune responses leading to dysregulated coagulation system and generalized thrombo-embolic status and increased risk of AIS especially among usually less vulnerable younger adults in this cohort. Thus, in early June 2020, we aimed to review the clinical data on all published cases of COVID-19 and concomitant AIS, with a view to understanding the pertinent clinical, laboratory and imaging features. The neutrophil-lymphocyte ratio (NLR) at time of hospital admission for COVID infection correlates positively with the duration of time before onset of clinical features of AIS. Higher NLR, C-Reactive protein, serum ferritin, D-dimer and fibrinogen levels are associated with poor prognosis of AIS in COVID-19 with 75% of patients dying or being severely disabled at present. Currently it is too early to comment on the long-term outcomes for survivors.https://www.frontiersin.org/article/10.3389/fneur.2020.01031/fullacute ischemic strokeCOVID-19neurorehabilitationwhite blood cellsneutrophil lymphocyte ratiohyper coagulopathy |
| spellingShingle | Tissa Wijeratne Tissa Wijeratne Tissa Wijeratne Carmela Sales Leila Karimi Leila Karimi Sheila Gillard Crewther Sheila Gillard Crewther Acute Ischemic Stroke in COVID-19: A Case-Based Systematic Review Frontiers in Neurology acute ischemic stroke COVID-19 neurorehabilitation white blood cells neutrophil lymphocyte ratio hyper coagulopathy |
| title | Acute Ischemic Stroke in COVID-19: A Case-Based Systematic Review |
| title_full | Acute Ischemic Stroke in COVID-19: A Case-Based Systematic Review |
| title_fullStr | Acute Ischemic Stroke in COVID-19: A Case-Based Systematic Review |
| title_full_unstemmed | Acute Ischemic Stroke in COVID-19: A Case-Based Systematic Review |
| title_short | Acute Ischemic Stroke in COVID-19: A Case-Based Systematic Review |
| title_sort | acute ischemic stroke in covid 19 a case based systematic review |
| topic | acute ischemic stroke COVID-19 neurorehabilitation white blood cells neutrophil lymphocyte ratio hyper coagulopathy |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.01031/full |
| work_keys_str_mv | AT tissawijeratne acuteischemicstrokeincovid19acasebasedsystematicreview AT tissawijeratne acuteischemicstrokeincovid19acasebasedsystematicreview AT tissawijeratne acuteischemicstrokeincovid19acasebasedsystematicreview AT carmelasales acuteischemicstrokeincovid19acasebasedsystematicreview AT leilakarimi acuteischemicstrokeincovid19acasebasedsystematicreview AT leilakarimi acuteischemicstrokeincovid19acasebasedsystematicreview AT sheilagillardcrewther acuteischemicstrokeincovid19acasebasedsystematicreview AT sheilagillardcrewther acuteischemicstrokeincovid19acasebasedsystematicreview |