The Multiple Roles of FGF Signaling in the Developing Spinal Cord
During vertebrate embryonic development, the spinal cord is formed by the neural derivatives of a neuromesodermal population that is specified at early stages of development and which develops in concert with the caudal regression of the primitive streak. Several processes related to spinal cord spe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fcell.2017.00058/full |
| _version_ | 1828161470666375168 |
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| author | Ruth Diez del Corral Ruth Diez del Corral Aixa V. Morales |
| author_facet | Ruth Diez del Corral Ruth Diez del Corral Aixa V. Morales |
| author_sort | Ruth Diez del Corral |
| collection | DOAJ |
| description | During vertebrate embryonic development, the spinal cord is formed by the neural derivatives of a neuromesodermal population that is specified at early stages of development and which develops in concert with the caudal regression of the primitive streak. Several processes related to spinal cord specification and maturation are coupled to this caudal extension including neurogenesis, ventral patterning and neural crest specification and all of them seem to be crucially regulated by Fibroblast Growth Factor (FGF) signaling, which is prominently active in the neuromesodermal region and transiently in its derivatives. Here we review the role of FGF signaling in those processes, trying to separate its different functions and highlighting the interactions with other signaling pathways. Finally, these early functions of FGF signaling in spinal cord development may underlay partly its ability to promote regeneration in the lesioned spinal cord as well as its action promoting specific fates in neural stem cell cultures that may be used for therapeutical purposes. |
| first_indexed | 2024-04-12T00:39:05Z |
| format | Article |
| id | doaj.art-fe7b7d04fb0f4931b8232732692350af |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-12T00:39:05Z |
| publishDate | 2017-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-fe7b7d04fb0f4931b8232732692350af2022-12-22T03:55:04ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2017-06-01510.3389/fcell.2017.00058260791The Multiple Roles of FGF Signaling in the Developing Spinal CordRuth Diez del Corral0Ruth Diez del Corral1Aixa V. Morales2Department of Cellular, Molecular and Developmental Neurobiology, Cajal Institute, Consejo Superior de Investigaciones CientíficasMadrid, SpainChampalimaud Research, Champalimaud Centre for the UnknownLisbon, PortugalDepartment of Cellular, Molecular and Developmental Neurobiology, Cajal Institute, Consejo Superior de Investigaciones CientíficasMadrid, SpainDuring vertebrate embryonic development, the spinal cord is formed by the neural derivatives of a neuromesodermal population that is specified at early stages of development and which develops in concert with the caudal regression of the primitive streak. Several processes related to spinal cord specification and maturation are coupled to this caudal extension including neurogenesis, ventral patterning and neural crest specification and all of them seem to be crucially regulated by Fibroblast Growth Factor (FGF) signaling, which is prominently active in the neuromesodermal region and transiently in its derivatives. Here we review the role of FGF signaling in those processes, trying to separate its different functions and highlighting the interactions with other signaling pathways. Finally, these early functions of FGF signaling in spinal cord development may underlay partly its ability to promote regeneration in the lesioned spinal cord as well as its action promoting specific fates in neural stem cell cultures that may be used for therapeutical purposes.http://journal.frontiersin.org/article/10.3389/fcell.2017.00058/fullspinal cordspinal cord injuryneuromesodermal progenitorsneural stem cellspatterningneurogenesis |
| spellingShingle | Ruth Diez del Corral Ruth Diez del Corral Aixa V. Morales The Multiple Roles of FGF Signaling in the Developing Spinal Cord Frontiers in Cell and Developmental Biology spinal cord spinal cord injury neuromesodermal progenitors neural stem cells patterning neurogenesis |
| title | The Multiple Roles of FGF Signaling in the Developing Spinal Cord |
| title_full | The Multiple Roles of FGF Signaling in the Developing Spinal Cord |
| title_fullStr | The Multiple Roles of FGF Signaling in the Developing Spinal Cord |
| title_full_unstemmed | The Multiple Roles of FGF Signaling in the Developing Spinal Cord |
| title_short | The Multiple Roles of FGF Signaling in the Developing Spinal Cord |
| title_sort | multiple roles of fgf signaling in the developing spinal cord |
| topic | spinal cord spinal cord injury neuromesodermal progenitors neural stem cells patterning neurogenesis |
| url | http://journal.frontiersin.org/article/10.3389/fcell.2017.00058/full |
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