Association Between Maternal Fasting Plasma Glucose Value and Fetal Weight Among Singletons of Mothers with Gestational Diabetes Mellitus
Yingying Wei,1,* Jiahuan Peng,2,* Han Li,1 Mengtian Wei,1 Hao Peng,1 Kai Wang,1 Yongfu Yu,2 Qizhi He3 1Clinical and Translational Research Center, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University,...
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| Format: | Article |
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Dove Medical Press
2022-12-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/association-between-maternal-fasting-plasma-glucose-value-and-fetal-we-peer-reviewed-fulltext-article-DMSO |
| _version_ | 1797705031071301632 |
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| author | Wei Y Peng J Li H Wei M Peng H Wang K Yu Y He Q |
| author_facet | Wei Y Peng J Li H Wei M Peng H Wang K Yu Y He Q |
| author_sort | Wei Y |
| collection | DOAJ |
| description | Yingying Wei,1,* Jiahuan Peng,2,* Han Li,1 Mengtian Wei,1 Hao Peng,1 Kai Wang,1 Yongfu Yu,2 Qizhi He3 1Clinical and Translational Research Center, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 2Department of Biostatistics, School of Public Health, Fudan University, Shanghai, People’s Republic of China; 3Department of Pathology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qizhi He, Department of Pathology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, No. 2699, West Gaoke Road, Pudong District, Shanghai, 201204, People’s Republic of China, Fax +86-2120261141, Email qizhihe2013@163.comPurpose: Infants with macrosomia are more likely to be born to mothers with gestational diabetes mellitus (GDM). This study aimed to investigate the associations between maternal blood glucose levels and fetal weight, placental weight, and risk of macrosomia in mothers with GDM.Patients and Methods: This retrospective study included 3211 singletons of mothers with GDM at the Shanghai First Maternity and Infant Hospital between January 2017 and December 2019. All women underwent an oral glucose tolerance test (OGTT) during the 24– 28 weeks gestation period. Data on fetal and placental parameters were collected at delivery. Multiple linear regression models were used to evaluate the associations of maternal blood glucose levels with fetal weight and placental weight, while multiple logistic regression model was used to estimate the association between maternal blood glucose levels and the risk of macrosomia.Results: The prevalence of GDM in our study was 7%. Fasting plasma glucose (FPG) was positively correlated with fetal weight (r2=0.0329, P< 0.001), and macrosomia risk (odds ratio [OR], 2.42; 95% confidence interval [CI], 1.93– 3.04; P< 0.001). After adjusting for gestational age, the result remained significant (OR, 2.67; 95% CI, 2.11– 3.38; P< 0.001). In contrast, there was no significant relationship between 1-h plasma glucose (1hPG) or 2-h plasma glucose (2hPG) and fetal weight (P=0.18, P=0.46). Additionally, 1hPG or 2hPG was not strongly associated with macrosomia risk (OR, 0.95; 95% CI, 0.85– 1.05; P=0.32 vs OR, 0.94; 95% CI, 0.85– 1.05; P=0.28). Maternal blood glucose levels did not affect placental weight. The associations were similar in women carrying male and female fetuses.Conclusion: Maternal fasting plasma glucose levels were strongly associated with increased birth weight and macrosomia risk. Our findings suggest that fasting plasma glucose may predict birth weight.Keywords: gestational diabetes mellitus, blood glucose levels, weight, macrosomia |
| first_indexed | 2024-03-12T05:29:13Z |
| format | Article |
| id | doaj.art-fe7bcca3cdfe4ae680be584a00385d2b |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-03-12T05:29:13Z |
| publishDate | 2022-12-01 |
| publisher | Dove Medical Press |
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| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-fe7bcca3cdfe4ae680be584a00385d2b2023-09-03T07:01:23ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072022-12-01Volume 153799380780223Association Between Maternal Fasting Plasma Glucose Value and Fetal Weight Among Singletons of Mothers with Gestational Diabetes MellitusWei YPeng JLi HWei MPeng HWang KYu YHe QYingying Wei,1,* Jiahuan Peng,2,* Han Li,1 Mengtian Wei,1 Hao Peng,1 Kai Wang,1 Yongfu Yu,2 Qizhi He3 1Clinical and Translational Research Center, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 2Department of Biostatistics, School of Public Health, Fudan University, Shanghai, People’s Republic of China; 3Department of Pathology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qizhi He, Department of Pathology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, No. 2699, West Gaoke Road, Pudong District, Shanghai, 201204, People’s Republic of China, Fax +86-2120261141, Email qizhihe2013@163.comPurpose: Infants with macrosomia are more likely to be born to mothers with gestational diabetes mellitus (GDM). This study aimed to investigate the associations between maternal blood glucose levels and fetal weight, placental weight, and risk of macrosomia in mothers with GDM.Patients and Methods: This retrospective study included 3211 singletons of mothers with GDM at the Shanghai First Maternity and Infant Hospital between January 2017 and December 2019. All women underwent an oral glucose tolerance test (OGTT) during the 24– 28 weeks gestation period. Data on fetal and placental parameters were collected at delivery. Multiple linear regression models were used to evaluate the associations of maternal blood glucose levels with fetal weight and placental weight, while multiple logistic regression model was used to estimate the association between maternal blood glucose levels and the risk of macrosomia.Results: The prevalence of GDM in our study was 7%. Fasting plasma glucose (FPG) was positively correlated with fetal weight (r2=0.0329, P< 0.001), and macrosomia risk (odds ratio [OR], 2.42; 95% confidence interval [CI], 1.93– 3.04; P< 0.001). After adjusting for gestational age, the result remained significant (OR, 2.67; 95% CI, 2.11– 3.38; P< 0.001). In contrast, there was no significant relationship between 1-h plasma glucose (1hPG) or 2-h plasma glucose (2hPG) and fetal weight (P=0.18, P=0.46). Additionally, 1hPG or 2hPG was not strongly associated with macrosomia risk (OR, 0.95; 95% CI, 0.85– 1.05; P=0.32 vs OR, 0.94; 95% CI, 0.85– 1.05; P=0.28). Maternal blood glucose levels did not affect placental weight. The associations were similar in women carrying male and female fetuses.Conclusion: Maternal fasting plasma glucose levels were strongly associated with increased birth weight and macrosomia risk. Our findings suggest that fasting plasma glucose may predict birth weight.Keywords: gestational diabetes mellitus, blood glucose levels, weight, macrosomiahttps://www.dovepress.com/association-between-maternal-fasting-plasma-glucose-value-and-fetal-we-peer-reviewed-fulltext-article-DMSOgestational diabetes mellitusblood glucose levelsweightmacrosomia |
| spellingShingle | Wei Y Peng J Li H Wei M Peng H Wang K Yu Y He Q Association Between Maternal Fasting Plasma Glucose Value and Fetal Weight Among Singletons of Mothers with Gestational Diabetes Mellitus Diabetes, Metabolic Syndrome and Obesity gestational diabetes mellitus blood glucose levels weight macrosomia |
| title | Association Between Maternal Fasting Plasma Glucose Value and Fetal Weight Among Singletons of Mothers with Gestational Diabetes Mellitus |
| title_full | Association Between Maternal Fasting Plasma Glucose Value and Fetal Weight Among Singletons of Mothers with Gestational Diabetes Mellitus |
| title_fullStr | Association Between Maternal Fasting Plasma Glucose Value and Fetal Weight Among Singletons of Mothers with Gestational Diabetes Mellitus |
| title_full_unstemmed | Association Between Maternal Fasting Plasma Glucose Value and Fetal Weight Among Singletons of Mothers with Gestational Diabetes Mellitus |
| title_short | Association Between Maternal Fasting Plasma Glucose Value and Fetal Weight Among Singletons of Mothers with Gestational Diabetes Mellitus |
| title_sort | association between maternal fasting plasma glucose value and fetal weight among singletons of mothers with gestational diabetes mellitus |
| topic | gestational diabetes mellitus blood glucose levels weight macrosomia |
| url | https://www.dovepress.com/association-between-maternal-fasting-plasma-glucose-value-and-fetal-we-peer-reviewed-fulltext-article-DMSO |
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