A Retrospective Study of Postictal Suppression during Electroconvulsive Therapy
Background: electroconvulsive therapy (ECT) is the most effective treatment in treatment-resistant depression (TRD), but its response remains partial. Identifying useful indicators to guide decision making for treatment and improve clinical response remains a major issue. The objective of the presen...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/5/1440 |
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| author | Virginie Moulier Julien Guehl Emilie Evêque-Mourroux Pierre Quesada Maud Rothärmel |
| author_facet | Virginie Moulier Julien Guehl Emilie Evêque-Mourroux Pierre Quesada Maud Rothärmel |
| author_sort | Virginie Moulier |
| collection | DOAJ |
| description | Background: electroconvulsive therapy (ECT) is the most effective treatment in treatment-resistant depression (TRD), but its response remains partial. Identifying useful indicators to guide decision making for treatment and improve clinical response remains a major issue. The objective of the present retrospective study was to determine if clinical response—early (after 5 ECT sessions) or longer-term (after 12 ECT sessions)—was associated with postictal suppression during the first ECT course and/or with postictal suppression frequency during the whole ECT course. Methods: in a retrospective study, the data of 42 patients suffering from treatment-resistant depression and receiving at least 5 ECT sessions were collected. Two sessions per week of bitemporal brief-pulse ECT sessions were administered to patients. Each of the electroencephalography (EEG) recordings were assessed to determine the presence of postictal suppression. Results: the postictal suppression from the first ECT session predicted a better long-term clinical response (after 12 ECT sessions), but not early clinical response (after only 5 ECT sessions). The postictal suppression frequency was associated with neither the short- nor the long-term clinical response. In addition, postictal suppression and short-term cognitive performances were not associated. Conclusions: this EEG indicator is clinically useful if it appears in the first ECT sessions, but it is no longer relevant in the following sessions. |
| first_indexed | 2024-03-09T20:34:34Z |
| format | Article |
| id | doaj.art-fe7cef4c0c3148dc9a4345af2af7d0bb |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T20:34:34Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-fe7cef4c0c3148dc9a4345af2af7d0bb2023-11-23T23:15:55ZengMDPI AGJournal of Clinical Medicine2077-03832022-03-01115144010.3390/jcm11051440A Retrospective Study of Postictal Suppression during Electroconvulsive TherapyVirginie Moulier0Julien Guehl1Emilie Evêque-Mourroux2Pierre Quesada3Maud Rothärmel4University Department of Psychiatry, Centre d’Excellence Thérapeutique, Institut de Psychiatrie, Centre Hospitalier du Rouvray, 76301 Sotteville-lès-Rouen, FranceUniversity Department of Psychiatry, Centre d’Excellence Thérapeutique, Institut de Psychiatrie, Centre Hospitalier du Rouvray, 76301 Sotteville-lès-Rouen, FranceUniversity Department of Psychiatry, Centre d’Excellence Thérapeutique, Institut de Psychiatrie, Centre Hospitalier du Rouvray, 76301 Sotteville-lès-Rouen, FranceUniversity Department of Psychiatry, Centre d’Excellence Thérapeutique, Institut de Psychiatrie, Centre Hospitalier du Rouvray, 76301 Sotteville-lès-Rouen, FranceUniversity Department of Psychiatry, Centre d’Excellence Thérapeutique, Institut de Psychiatrie, Centre Hospitalier du Rouvray, 76301 Sotteville-lès-Rouen, FranceBackground: electroconvulsive therapy (ECT) is the most effective treatment in treatment-resistant depression (TRD), but its response remains partial. Identifying useful indicators to guide decision making for treatment and improve clinical response remains a major issue. The objective of the present retrospective study was to determine if clinical response—early (after 5 ECT sessions) or longer-term (after 12 ECT sessions)—was associated with postictal suppression during the first ECT course and/or with postictal suppression frequency during the whole ECT course. Methods: in a retrospective study, the data of 42 patients suffering from treatment-resistant depression and receiving at least 5 ECT sessions were collected. Two sessions per week of bitemporal brief-pulse ECT sessions were administered to patients. Each of the electroencephalography (EEG) recordings were assessed to determine the presence of postictal suppression. Results: the postictal suppression from the first ECT session predicted a better long-term clinical response (after 12 ECT sessions), but not early clinical response (after only 5 ECT sessions). The postictal suppression frequency was associated with neither the short- nor the long-term clinical response. In addition, postictal suppression and short-term cognitive performances were not associated. Conclusions: this EEG indicator is clinically useful if it appears in the first ECT sessions, but it is no longer relevant in the following sessions.https://www.mdpi.com/2077-0383/11/5/1440electroconvulsive therapy (ECT)treatment-resistant depression (TRD)postictal suppressionelectroencephalography (EEG) |
| spellingShingle | Virginie Moulier Julien Guehl Emilie Evêque-Mourroux Pierre Quesada Maud Rothärmel A Retrospective Study of Postictal Suppression during Electroconvulsive Therapy Journal of Clinical Medicine electroconvulsive therapy (ECT) treatment-resistant depression (TRD) postictal suppression electroencephalography (EEG) |
| title | A Retrospective Study of Postictal Suppression during Electroconvulsive Therapy |
| title_full | A Retrospective Study of Postictal Suppression during Electroconvulsive Therapy |
| title_fullStr | A Retrospective Study of Postictal Suppression during Electroconvulsive Therapy |
| title_full_unstemmed | A Retrospective Study of Postictal Suppression during Electroconvulsive Therapy |
| title_short | A Retrospective Study of Postictal Suppression during Electroconvulsive Therapy |
| title_sort | retrospective study of postictal suppression during electroconvulsive therapy |
| topic | electroconvulsive therapy (ECT) treatment-resistant depression (TRD) postictal suppression electroencephalography (EEG) |
| url | https://www.mdpi.com/2077-0383/11/5/1440 |
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