An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells
Modelling gene expression and proliferation dynamics of pluripotent stem cells Mouse embryonic stem cells (mESCs) are pluripotent cells, having the potential to turn into most other cell types. A team led by Lucia Marucci at the University of Bristol, and involving collaborators from the University...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-08-01
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| Series: | npj Systems Biology and Applications |
| Online Access: | https://doi.org/10.1038/s41540-017-0020-5 |
| _version_ | 1818856163829088256 |
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| author | Simon Godwin Daniel Ward Elisa Pedone Martin Homer Alexander G. Fletcher Lucia Marucci |
| author_facet | Simon Godwin Daniel Ward Elisa Pedone Martin Homer Alexander G. Fletcher Lucia Marucci |
| author_sort | Simon Godwin |
| collection | DOAJ |
| description | Modelling gene expression and proliferation dynamics of pluripotent stem cells Mouse embryonic stem cells (mESCs) are pluripotent cells, having the potential to turn into most other cell types. A team led by Lucia Marucci at the University of Bristol, and involving collaborators from the University of Sheffield, developed mathematical models to describe temporal dynamics of pluripotency genes in mESCs under different culture conditions. The team shows that the combination of feedback loops in the underlying gene regulatory networks, noise, and culture conditions fine-tunes gene expression dynamics and, consequently, the fate of mESCs. Experimental and modelling results highlight the interplay between pluripotency gene dynamics and cellular proliferation. Understanding the dynamical mechanisms that influence the fate of mESCs could guide the optimisation of culture protocols in both pluripotency and differentiation. |
| first_indexed | 2024-12-19T08:20:08Z |
| format | Article |
| id | doaj.art-fe7d280fe2fc44c489dde0d578fcc759 |
| institution | Directory Open Access Journal |
| issn | 2056-7189 |
| language | English |
| last_indexed | 2024-12-19T08:20:08Z |
| publishDate | 2017-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Systems Biology and Applications |
| spelling | doaj.art-fe7d280fe2fc44c489dde0d578fcc7592022-12-21T20:29:26ZengNature Portfolionpj Systems Biology and Applications2056-71892017-08-013111210.1038/s41540-017-0020-5An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cellsSimon Godwin0Daniel Ward1Elisa Pedone2Martin Homer3Alexander G. Fletcher4Lucia Marucci5Department of Engineering Mathematics, University of BristolDepartment of Engineering Mathematics, University of BristolDepartment of Engineering Mathematics, University of BristolDepartment of Engineering Mathematics, University of BristolSchool of Mathematics and Statistics, University of SheffieldDepartment of Engineering Mathematics, University of BristolModelling gene expression and proliferation dynamics of pluripotent stem cells Mouse embryonic stem cells (mESCs) are pluripotent cells, having the potential to turn into most other cell types. A team led by Lucia Marucci at the University of Bristol, and involving collaborators from the University of Sheffield, developed mathematical models to describe temporal dynamics of pluripotency genes in mESCs under different culture conditions. The team shows that the combination of feedback loops in the underlying gene regulatory networks, noise, and culture conditions fine-tunes gene expression dynamics and, consequently, the fate of mESCs. Experimental and modelling results highlight the interplay between pluripotency gene dynamics and cellular proliferation. Understanding the dynamical mechanisms that influence the fate of mESCs could guide the optimisation of culture protocols in both pluripotency and differentiation.https://doi.org/10.1038/s41540-017-0020-5 |
| spellingShingle | Simon Godwin Daniel Ward Elisa Pedone Martin Homer Alexander G. Fletcher Lucia Marucci An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells npj Systems Biology and Applications |
| title | An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells |
| title_full | An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells |
| title_fullStr | An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells |
| title_full_unstemmed | An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells |
| title_short | An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells |
| title_sort | extended model for culture dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells |
| url | https://doi.org/10.1038/s41540-017-0020-5 |
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