Expression of targets of the RNA-binding protein AUF-1 in human airway epithelium indicates its role in cellular senescence and inflammation

Expression of targets of the RNA-binding protein AUF-1 in human airway epithelium indicates its role in cellular senescence and inflammation

IntroductionThe RNA-binding protein AU-rich-element factor-1 (AUF-1) participates to posttranscriptional regulation of genes involved in inflammation and cellular senescence, two pathogenic mechanisms of chronic obstructive pulmonary disease (COPD). Decreased AUF-1 expression was described in bronch...

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Main Authors: Ilaria Salvato, Luca Ricciardi, Jessica Dal Col, Annunziata Nigro, Giorgio Giurato, Domenico Memoli, Assunta Sellitto, Erwin Pavel Lamparelli, Maria Assunta Crescenzi, Monica Vitale, Alessandro Vatrella, Francesco Nucera, Paola Brun, Federico Caicci, Paola Dama, Thomas Stiff, Leandro Castellano, Sobia Idrees, Matt D. Johansen, Alen Faiz, Peter A. Wark, Philip M. Hansbro, Ian M. Adcock, Gaetano Caramori, Cristiana Stellato
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
airway epithelium
AU-rich element factor 1 (AUF-1)
cell senescence
chronic inflammation
chronic obstructive pulmonary disease
inflammaging
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1192028/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1192028/full

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