Serum Taurine and Stroke Risk in Women: A Prospective, Nested Case-Control Study.
BACKGROUND:Taurine (2-aminoethanesulfonic acid), a conditionally essential sulfur-containing amino acid, is mainly obtained from diet in humans. Experimental studies have shown that taurine's main biological actions include bile salt conjugation, blood pressure regulation, anti-oxidation, and a...
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| Format: | Article |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4750934?pdf=render |
| _version_ | 1819072138251862016 |
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| author | Fen Wu Karen L Koenig Anne Zeleniuch-Jacquotte Saran Jonas Yelena Afanasyeva Oktawia P Wójcik Max Costa Yu Chen |
| author_facet | Fen Wu Karen L Koenig Anne Zeleniuch-Jacquotte Saran Jonas Yelena Afanasyeva Oktawia P Wójcik Max Costa Yu Chen |
| author_sort | Fen Wu |
| collection | DOAJ |
| description | BACKGROUND:Taurine (2-aminoethanesulfonic acid), a conditionally essential sulfur-containing amino acid, is mainly obtained from diet in humans. Experimental studies have shown that taurine's main biological actions include bile salt conjugation, blood pressure regulation, anti-oxidation, and anti-inflammation. METHODS:We conducted a prospective case-control study nested in the New York University Women's Health Study, a cohort study involving 14,274 women enrolled since 1985. Taurine was measured in pre-diagnostic serum samples of 241 stroke cases and 479 matched controls. RESULTS:There was no statistically significant association between serum taurine and stroke risk in the overall study population. The adjusted ORs for stroke were 1.0 (reference), 0.87 (95% CI, 0.59-1.28), and 1.03 (95% CI, 0.69-1.54) in increasing tertiles of taurine (64.3-126.6, 126.7-152.9, and 153.0-308.5 nmol/mL, respectively). A significant inverse association between serum taurine and stroke risk was observed among never smokers, with an adjusted OR of 0.66 (95% CI, 0.37-1.18) and 0.50 (95% CI, 0.26-0.94) for the second and third tertile, respectively (p for trend = 0.01), but not among past or current smokers (p for interaction < 0.01). CONCLUSIONS:We observed no overall association between serum taurine and stroke risk, although a protective effect was observed in never smokers, which requires further investigation. Taurine, Stroke, Epidemiology, Prospective, Case-control study, NYUWHS. |
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| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T17:32:57Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-fe80045d70b2466cbdece750eedd16c52022-12-21T18:55:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01112e014934810.1371/journal.pone.0149348Serum Taurine and Stroke Risk in Women: A Prospective, Nested Case-Control Study.Fen WuKaren L KoenigAnne Zeleniuch-JacquotteSaran JonasYelena AfanasyevaOktawia P WójcikMax CostaYu ChenBACKGROUND:Taurine (2-aminoethanesulfonic acid), a conditionally essential sulfur-containing amino acid, is mainly obtained from diet in humans. Experimental studies have shown that taurine's main biological actions include bile salt conjugation, blood pressure regulation, anti-oxidation, and anti-inflammation. METHODS:We conducted a prospective case-control study nested in the New York University Women's Health Study, a cohort study involving 14,274 women enrolled since 1985. Taurine was measured in pre-diagnostic serum samples of 241 stroke cases and 479 matched controls. RESULTS:There was no statistically significant association between serum taurine and stroke risk in the overall study population. The adjusted ORs for stroke were 1.0 (reference), 0.87 (95% CI, 0.59-1.28), and 1.03 (95% CI, 0.69-1.54) in increasing tertiles of taurine (64.3-126.6, 126.7-152.9, and 153.0-308.5 nmol/mL, respectively). A significant inverse association between serum taurine and stroke risk was observed among never smokers, with an adjusted OR of 0.66 (95% CI, 0.37-1.18) and 0.50 (95% CI, 0.26-0.94) for the second and third tertile, respectively (p for trend = 0.01), but not among past or current smokers (p for interaction < 0.01). CONCLUSIONS:We observed no overall association between serum taurine and stroke risk, although a protective effect was observed in never smokers, which requires further investigation. Taurine, Stroke, Epidemiology, Prospective, Case-control study, NYUWHS.http://europepmc.org/articles/PMC4750934?pdf=render |
| spellingShingle | Fen Wu Karen L Koenig Anne Zeleniuch-Jacquotte Saran Jonas Yelena Afanasyeva Oktawia P Wójcik Max Costa Yu Chen Serum Taurine and Stroke Risk in Women: A Prospective, Nested Case-Control Study. PLoS ONE |
| title | Serum Taurine and Stroke Risk in Women: A Prospective, Nested Case-Control Study. |
| title_full | Serum Taurine and Stroke Risk in Women: A Prospective, Nested Case-Control Study. |
| title_fullStr | Serum Taurine and Stroke Risk in Women: A Prospective, Nested Case-Control Study. |
| title_full_unstemmed | Serum Taurine and Stroke Risk in Women: A Prospective, Nested Case-Control Study. |
| title_short | Serum Taurine and Stroke Risk in Women: A Prospective, Nested Case-Control Study. |
| title_sort | serum taurine and stroke risk in women a prospective nested case control study |
| url | http://europepmc.org/articles/PMC4750934?pdf=render |
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