Fractal evolution of dual pH- and temperature-responsive P(NIPAM-co-AA)@BMMs with bimodal mesoporous silica core and coated-copolymer shell during drug delivery procedure via SAXS characterization
The dual (pH- and temperature-) responsive core-shell structured mesoporous nanomaterial P@BMMs were prepared using bimodal mesoporous silica as a core and poly(N-isopropylacrylamide-co-acrylic acid) P(NIPAM-co-AA) copolymer as a shell. Ibuprofen (IBU) was used as a model drug, and the effects of co...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-02-01
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| Series: | Arabian Journal of Chemistry |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535219300723 |
| _version_ | 1818511000425463808 |
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| author | Jiayu Ma Jihong Sun Li Fan Shiyang Bai Hamida Panezai Yuwen Jiao |
| author_facet | Jiayu Ma Jihong Sun Li Fan Shiyang Bai Hamida Panezai Yuwen Jiao |
| author_sort | Jiayu Ma |
| collection | DOAJ |
| description | The dual (pH- and temperature-) responsive core-shell structured mesoporous nanomaterial P@BMMs were prepared using bimodal mesoporous silica as a core and poly(N-isopropylacrylamide-co-acrylic acid) P(NIPAM-co-AA) copolymer as a shell. Ibuprofen (IBU) was used as a model drug, and the effects of copolymer-coated shell thickness on drug loading and controlled release behavior were investigated by means of N2 sorption isotherms, dynamic light scattering measurements, X-ray diffraction patterns, Fourier transform infrared spectra, scanning electron and transmission electron microscopy, thermogravimetric profiles, and elemental analysis techniques. Particularly, their fractal evolutions in the drug delivery durations were explored via small angle X-ray scattering methods, demonstrating that the resultant P@BMMs before IBU-loading and after releasing possess the typical fractal features with spherical morphology. Meanwhile, the estimation for shell thickness of P@BMMs coating in different time intervals indicated that the drug-loaded capacity was improved with the increasing shell thickness, but drug-released rate varies, strongly depending on both shell thickness and release conditions. The drug delivery mechanism was preliminarily explored, following the Korsmeyer-Peppas model. Finally, cytotoxicity in cell and pharmacokinetic of released-IBU from hybrid nanocomposite in mice via intravenously injection were preliminarily explored. Keywords: Fractal, Mesoporous SiO2, Core-shell structures, SAXS, Dual (pH- and temperature-) responsive |
| first_indexed | 2024-12-10T23:27:36Z |
| format | Article |
| id | doaj.art-fe80c5f810454e64823ef01635a510ea |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-10T23:27:36Z |
| publishDate | 2020-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-fe80c5f810454e64823ef01635a510ea2022-12-22T01:29:32ZengElsevierArabian Journal of Chemistry1878-53522020-02-0113241474161Fractal evolution of dual pH- and temperature-responsive P(NIPAM-co-AA)@BMMs with bimodal mesoporous silica core and coated-copolymer shell during drug delivery procedure via SAXS characterizationJiayu Ma0Jihong Sun1Li Fan2Shiyang Bai3Hamida Panezai4Yuwen Jiao5Beijing Key Laboratory for Green Catalysis and Separation, Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, ChinaBeijing Key Laboratory for Green Catalysis and Separation, Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China; Corresponding authors at: Beijing Key Laboratory for Green Catalysis and Separation, Department of Chemistry and Chemical Engineering, Beijing University of Technology, 100 PingLeYuan, Chaoyang District, Beijing 100124, China.Department of Pharmaceutical Chemistry and Analysis, School of Pharmacy, The Fourth Military Medical University, Xi’an 7100032, Shanxi Province, China; Corresponding authors at: Beijing Key Laboratory for Green Catalysis and Separation, Department of Chemistry and Chemical Engineering, Beijing University of Technology, 100 PingLeYuan, Chaoyang District, Beijing 100124, China.Beijing Key Laboratory for Green Catalysis and Separation, Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, ChinaBeijing Key Laboratory for Green Catalysis and Separation, Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, ChinaDepartment of Pharmaceutical Chemistry and Analysis, School of Pharmacy, The Fourth Military Medical University, Xi’an 7100032, Shanxi Province, ChinaThe dual (pH- and temperature-) responsive core-shell structured mesoporous nanomaterial P@BMMs were prepared using bimodal mesoporous silica as a core and poly(N-isopropylacrylamide-co-acrylic acid) P(NIPAM-co-AA) copolymer as a shell. Ibuprofen (IBU) was used as a model drug, and the effects of copolymer-coated shell thickness on drug loading and controlled release behavior were investigated by means of N2 sorption isotherms, dynamic light scattering measurements, X-ray diffraction patterns, Fourier transform infrared spectra, scanning electron and transmission electron microscopy, thermogravimetric profiles, and elemental analysis techniques. Particularly, their fractal evolutions in the drug delivery durations were explored via small angle X-ray scattering methods, demonstrating that the resultant P@BMMs before IBU-loading and after releasing possess the typical fractal features with spherical morphology. Meanwhile, the estimation for shell thickness of P@BMMs coating in different time intervals indicated that the drug-loaded capacity was improved with the increasing shell thickness, but drug-released rate varies, strongly depending on both shell thickness and release conditions. The drug delivery mechanism was preliminarily explored, following the Korsmeyer-Peppas model. Finally, cytotoxicity in cell and pharmacokinetic of released-IBU from hybrid nanocomposite in mice via intravenously injection were preliminarily explored. Keywords: Fractal, Mesoporous SiO2, Core-shell structures, SAXS, Dual (pH- and temperature-) responsivehttp://www.sciencedirect.com/science/article/pii/S1878535219300723 |
| spellingShingle | Jiayu Ma Jihong Sun Li Fan Shiyang Bai Hamida Panezai Yuwen Jiao Fractal evolution of dual pH- and temperature-responsive P(NIPAM-co-AA)@BMMs with bimodal mesoporous silica core and coated-copolymer shell during drug delivery procedure via SAXS characterization Arabian Journal of Chemistry |
| title | Fractal evolution of dual pH- and temperature-responsive P(NIPAM-co-AA)@BMMs with bimodal mesoporous silica core and coated-copolymer shell during drug delivery procedure via SAXS characterization |
| title_full | Fractal evolution of dual pH- and temperature-responsive P(NIPAM-co-AA)@BMMs with bimodal mesoporous silica core and coated-copolymer shell during drug delivery procedure via SAXS characterization |
| title_fullStr | Fractal evolution of dual pH- and temperature-responsive P(NIPAM-co-AA)@BMMs with bimodal mesoporous silica core and coated-copolymer shell during drug delivery procedure via SAXS characterization |
| title_full_unstemmed | Fractal evolution of dual pH- and temperature-responsive P(NIPAM-co-AA)@BMMs with bimodal mesoporous silica core and coated-copolymer shell during drug delivery procedure via SAXS characterization |
| title_short | Fractal evolution of dual pH- and temperature-responsive P(NIPAM-co-AA)@BMMs with bimodal mesoporous silica core and coated-copolymer shell during drug delivery procedure via SAXS characterization |
| title_sort | fractal evolution of dual ph and temperature responsive p nipam co aa bmms with bimodal mesoporous silica core and coated copolymer shell during drug delivery procedure via saxs characterization |
| url | http://www.sciencedirect.com/science/article/pii/S1878535219300723 |
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