Structure of the glucosyltransferase domain of TcdA in complex with RhoA provides insights into substrate recognition
Abstract Clostridioides difficile is one of the most common causes of antibiotic-associated diarrhea in developed countries. As key virulence factors of C. difficile, toxin A (TcdA) and toxin B (TcdB) act by glucosylating and inactivating Rho and Ras family small GTPases in host cells, which leads t...
| Main Authors: | , , , |
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| 格式: | 文件 |
| 语言: | English |
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Nature Portfolio
2022-05-01
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| 丛编: | Scientific Reports |
| 在线阅读: | https://doi.org/10.1038/s41598-022-12909-8 |