Oenothein B, a Bioactive Ellagitannin, Activates the Extracellular Signal-Regulated Kinase 2 Signaling Pathway in the Mouse Brain
(1) Background: Oenothein B, a cyclic dimeric ellagitannin present in various medicinal plants, has been reported to exert diverse effects that are beneficial for the treatment and prevention of diseases, including cancer and infections. We recently showed that oenothein B also functions in the brai...
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| Format: | Article |
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MDPI AG
2021-05-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/10/5/1030 |
| _version_ | 1797533381064392704 |
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| author | Satoshi Okuyama Yoshiko Furukawa Morio Yoshimura Yoshiaki Amakura Mitsunari Nakajima Takashi Yoshida |
| author_facet | Satoshi Okuyama Yoshiko Furukawa Morio Yoshimura Yoshiaki Amakura Mitsunari Nakajima Takashi Yoshida |
| author_sort | Satoshi Okuyama |
| collection | DOAJ |
| description | (1) Background: Oenothein B, a cyclic dimeric ellagitannin present in various medicinal plants, has been reported to exert diverse effects that are beneficial for the treatment and prevention of diseases, including cancer and infections. We recently showed that oenothein B also functions in the brain because its oral administration to systemic inflammatory model mice reduced inflammatory responses in the brain and suppressed abnormal behavior. (2) Results: The present in vivo results demonstrated that oenothein B activated extracellular signal-regulated kinase 2 and cAMP response element-binding protein in the brain, both of which play important roles in synaptic transmission and learning/memory in the central nervous system (CNS). (3) Conclusions: These results suggest that oenothein B exerts neuroprotective effects on the CNS by not only its anti-inflammatory activity but also by enhancing neuronal signaling pathways. |
| first_indexed | 2024-03-10T11:13:46Z |
| format | Article |
| id | doaj.art-fe8171fc23de45c087d3b4950ff396c9 |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-10T11:13:46Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-fe8171fc23de45c087d3b4950ff396c92023-11-21T20:38:29ZengMDPI AGPlants2223-77472021-05-01105103010.3390/plants10051030Oenothein B, a Bioactive Ellagitannin, Activates the Extracellular Signal-Regulated Kinase 2 Signaling Pathway in the Mouse BrainSatoshi Okuyama0Yoshiko Furukawa1Morio Yoshimura2Yoshiaki Amakura3Mitsunari Nakajima4Takashi Yoshida5Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama 790-8578, Ehime, JapanDepartment of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama 790-8578, Ehime, JapanDepartment of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama 790-8578, Ehime, JapanDepartment of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama 790-8578, Ehime, JapanDepartment of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama 790-8578, Ehime, JapanDepartment of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama 790-8578, Ehime, Japan(1) Background: Oenothein B, a cyclic dimeric ellagitannin present in various medicinal plants, has been reported to exert diverse effects that are beneficial for the treatment and prevention of diseases, including cancer and infections. We recently showed that oenothein B also functions in the brain because its oral administration to systemic inflammatory model mice reduced inflammatory responses in the brain and suppressed abnormal behavior. (2) Results: The present in vivo results demonstrated that oenothein B activated extracellular signal-regulated kinase 2 and cAMP response element-binding protein in the brain, both of which play important roles in synaptic transmission and learning/memory in the central nervous system (CNS). (3) Conclusions: These results suggest that oenothein B exerts neuroprotective effects on the CNS by not only its anti-inflammatory activity but also by enhancing neuronal signaling pathways.https://www.mdpi.com/2223-7747/10/5/1030oenothein Bellagitanninneuroprotectionextracellular signal-regulated kinase (ERK)cAMP response element-binding protein (CREB)brain |
| spellingShingle | Satoshi Okuyama Yoshiko Furukawa Morio Yoshimura Yoshiaki Amakura Mitsunari Nakajima Takashi Yoshida Oenothein B, a Bioactive Ellagitannin, Activates the Extracellular Signal-Regulated Kinase 2 Signaling Pathway in the Mouse Brain Plants oenothein B ellagitannin neuroprotection extracellular signal-regulated kinase (ERK) cAMP response element-binding protein (CREB) brain |
| title | Oenothein B, a Bioactive Ellagitannin, Activates the Extracellular Signal-Regulated Kinase 2 Signaling Pathway in the Mouse Brain |
| title_full | Oenothein B, a Bioactive Ellagitannin, Activates the Extracellular Signal-Regulated Kinase 2 Signaling Pathway in the Mouse Brain |
| title_fullStr | Oenothein B, a Bioactive Ellagitannin, Activates the Extracellular Signal-Regulated Kinase 2 Signaling Pathway in the Mouse Brain |
| title_full_unstemmed | Oenothein B, a Bioactive Ellagitannin, Activates the Extracellular Signal-Regulated Kinase 2 Signaling Pathway in the Mouse Brain |
| title_short | Oenothein B, a Bioactive Ellagitannin, Activates the Extracellular Signal-Regulated Kinase 2 Signaling Pathway in the Mouse Brain |
| title_sort | oenothein b a bioactive ellagitannin activates the extracellular signal regulated kinase 2 signaling pathway in the mouse brain |
| topic | oenothein B ellagitannin neuroprotection extracellular signal-regulated kinase (ERK) cAMP response element-binding protein (CREB) brain |
| url | https://www.mdpi.com/2223-7747/10/5/1030 |
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