Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-differential effects via GAUDI

Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-differential effects via GAUDI

Abstract Polygenic risk scores (PRS) have shown successes in clinics, but most PRS methods focus only on participants with distinct primary continental ancestry without accommodating recently-admixed individuals with mosaic continental ancestry backgrounds for different segments of their genomes. He...

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Bibliographic Details
Main Authors:	Quan Sun, Bryce T. Rowland, Jiawen Chen, Anna V. Mikhaylova, Christy Avery, Ulrike Peters, Jessica Lundin, Tara Matise, Steve Buyske, Ran Tao, Rasika A. Mathias, Alexander P. Reiner, Paul L. Auer, Nancy J. Cox, Charles Kooperberg, Timothy A. Thornton, Laura M. Raffield, Yun Li
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-024-45135-z

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