Hypoxia-Inducible Non-coding RNAs in Mesenchymal Stem Cell Fate and Regeneration
Mesenchymal stem cells (MSCs) can differentiate into multiple cell lines, which makes them an important source of cells for tissue engineering applications. They are defined by the capability to renew themselves and maintain pluripotency. This ability is modulated by the balance between complex cues...
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Dental Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fdmed.2021.799716/full |
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| author | Yu Ye Yu Ye Xinyuan Zhao Xinyuan Zhao Yan Xu Yan Xu Jinhua Yu Jinhua Yu |
| author_facet | Yu Ye Yu Ye Xinyuan Zhao Xinyuan Zhao Yan Xu Yan Xu Jinhua Yu Jinhua Yu |
| author_sort | Yu Ye |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) can differentiate into multiple cell lines, which makes them an important source of cells for tissue engineering applications. They are defined by the capability to renew themselves and maintain pluripotency. This ability is modulated by the balance between complex cues from cellular microenvironment. Self-renewal and differentiation abilities are regulated by particular microenvironmental signals. Oxygen is considered to be an important part of cell microenvironment, which not only acts as a metabolic substrate but also a signal molecule. It has been proved that MSCs are hypoxic in the physiological environment. Signals from MSCs' microenvironment or niche which means the anatomical location of the MSCs, maintain the final properties of MSCs. Physiological conditions like oxygen tension are deemed to be a significant part of the mesenchymal stem cell niche, and have been proved to be involved in modulating embryonic and adult MSCs. Non-coding RNAs (ncRNAs), which play a key role in cell signal transduction, transcription and translation of genes, have been widely concerned as epigenetic regulators in a great deal of tissues. With the rapid development of bioinformatics analysis tools and high-throughput RNA sequencing technology, more and more evidences show that ncRNAs play a key role in tissue regeneration. It shows potential as a biomarker of MSC differentiation. In this paper, we reviewed the physiological correlation of hypoxia as a unique environmental parameter which is conducive to MSC expansion and maintenance, discussed the correlation of tissue engineering, and summarized the influence of hypoxia related ncRNAs on MSCs' fate and regeneration. This review will provide reference for future research of MSCs' regeneration. |
| first_indexed | 2024-12-13T18:59:21Z |
| format | Article |
| id | doaj.art-fe8479a1bf764268906222b259369b86 |
| institution | Directory Open Access Journal |
| issn | 2673-4915 |
| language | English |
| last_indexed | 2024-12-13T18:59:21Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Dental Medicine |
| spelling | doaj.art-fe8479a1bf764268906222b259369b862022-12-21T23:34:43ZengFrontiers Media S.A.Frontiers in Dental Medicine2673-49152021-12-01210.3389/fdmed.2021.799716799716Hypoxia-Inducible Non-coding RNAs in Mesenchymal Stem Cell Fate and RegenerationYu Ye0Yu Ye1Xinyuan Zhao2Xinyuan Zhao3Yan Xu4Yan Xu5Jinhua Yu6Jinhua Yu7Key Laboratory of Oral Diseases of Jiangsu Province, Stomatological Institute, Nanjing Medical University, Nanjing, ChinaEndodontic Department, School of Stomatology, Nanjing Medical University, Nanjing, ChinaKey Laboratory of Oral Diseases of Jiangsu Province, Stomatological Institute, Nanjing Medical University, Nanjing, ChinaStomatological Hospital, Southern Medical University, Guangzhou, ChinaKey Laboratory of Oral Diseases of Jiangsu Province, Stomatological Institute, Nanjing Medical University, Nanjing, ChinaPeriodontics Department, School of Stomatology, Nanjing Medical University, Nanjing, ChinaKey Laboratory of Oral Diseases of Jiangsu Province, Stomatological Institute, Nanjing Medical University, Nanjing, ChinaEndodontic Department, School of Stomatology, Nanjing Medical University, Nanjing, ChinaMesenchymal stem cells (MSCs) can differentiate into multiple cell lines, which makes them an important source of cells for tissue engineering applications. They are defined by the capability to renew themselves and maintain pluripotency. This ability is modulated by the balance between complex cues from cellular microenvironment. Self-renewal and differentiation abilities are regulated by particular microenvironmental signals. Oxygen is considered to be an important part of cell microenvironment, which not only acts as a metabolic substrate but also a signal molecule. It has been proved that MSCs are hypoxic in the physiological environment. Signals from MSCs' microenvironment or niche which means the anatomical location of the MSCs, maintain the final properties of MSCs. Physiological conditions like oxygen tension are deemed to be a significant part of the mesenchymal stem cell niche, and have been proved to be involved in modulating embryonic and adult MSCs. Non-coding RNAs (ncRNAs), which play a key role in cell signal transduction, transcription and translation of genes, have been widely concerned as epigenetic regulators in a great deal of tissues. With the rapid development of bioinformatics analysis tools and high-throughput RNA sequencing technology, more and more evidences show that ncRNAs play a key role in tissue regeneration. It shows potential as a biomarker of MSC differentiation. In this paper, we reviewed the physiological correlation of hypoxia as a unique environmental parameter which is conducive to MSC expansion and maintenance, discussed the correlation of tissue engineering, and summarized the influence of hypoxia related ncRNAs on MSCs' fate and regeneration. This review will provide reference for future research of MSCs' regeneration.https://www.frontiersin.org/articles/10.3389/fdmed.2021.799716/fullhypoxiamesenchymal stem cellnon-coding RNAdifferentiationniche |
| spellingShingle | Yu Ye Yu Ye Xinyuan Zhao Xinyuan Zhao Yan Xu Yan Xu Jinhua Yu Jinhua Yu Hypoxia-Inducible Non-coding RNAs in Mesenchymal Stem Cell Fate and Regeneration Frontiers in Dental Medicine hypoxia mesenchymal stem cell non-coding RNA differentiation niche |
| title | Hypoxia-Inducible Non-coding RNAs in Mesenchymal Stem Cell Fate and Regeneration |
| title_full | Hypoxia-Inducible Non-coding RNAs in Mesenchymal Stem Cell Fate and Regeneration |
| title_fullStr | Hypoxia-Inducible Non-coding RNAs in Mesenchymal Stem Cell Fate and Regeneration |
| title_full_unstemmed | Hypoxia-Inducible Non-coding RNAs in Mesenchymal Stem Cell Fate and Regeneration |
| title_short | Hypoxia-Inducible Non-coding RNAs in Mesenchymal Stem Cell Fate and Regeneration |
| title_sort | hypoxia inducible non coding rnas in mesenchymal stem cell fate and regeneration |
| topic | hypoxia mesenchymal stem cell non-coding RNA differentiation niche |
| url | https://www.frontiersin.org/articles/10.3389/fdmed.2021.799716/full |
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