Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies
In recent studies we and others have identified the cellular proteins PML, hDaxx, and Sp100, which form a subnuclear structure known as nuclear domain 10 (ND10) or PML nuclear bodies (PML-NBs), as host restriction factors that counteract herpesviral infections by inhibiting viral replication at diff...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2009-12-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/1/3/1240/ |
| _version_ | 1818173281018052608 |
|---|---|
| author | Nina Tavalai Thomas Stamminger |
| author_facet | Nina Tavalai Thomas Stamminger |
| author_sort | Nina Tavalai |
| collection | DOAJ |
| description | In recent studies we and others have identified the cellular proteins PML, hDaxx, and Sp100, which form a subnuclear structure known as nuclear domain 10 (ND10) or PML nuclear bodies (PML-NBs), as host restriction factors that counteract herpesviral infections by inhibiting viral replication at different stages. The antiviral function of ND10, however, is antagonized by viral regulatory proteins (e.g., ICP0 of herpes simplex virus; IE1 of human cytomegalovirus) which induce either a modification or disruption of ND10. This review will summarize the current knowledge on how viral replication is inhibited by ND10 proteins. Furthermore, herpesviral strategies to defeat this host defense mechanism are discussed. |
| first_indexed | 2024-12-11T19:26:00Z |
| format | Article |
| id | doaj.art-fe8666acbd6c4093a7f43e9d7362224a |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-11T19:26:00Z |
| publishDate | 2009-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-fe8666acbd6c4093a7f43e9d7362224a2022-12-22T00:53:24ZengMDPI AGViruses1999-49152009-12-01131240126410.3390/v1031240Interplay between Herpesvirus Infection and Host Defense by PML Nuclear BodiesNina TavalaiThomas StammingerIn recent studies we and others have identified the cellular proteins PML, hDaxx, and Sp100, which form a subnuclear structure known as nuclear domain 10 (ND10) or PML nuclear bodies (PML-NBs), as host restriction factors that counteract herpesviral infections by inhibiting viral replication at different stages. The antiviral function of ND10, however, is antagonized by viral regulatory proteins (e.g., ICP0 of herpes simplex virus; IE1 of human cytomegalovirus) which induce either a modification or disruption of ND10. This review will summarize the current knowledge on how viral replication is inhibited by ND10 proteins. Furthermore, herpesviral strategies to defeat this host defense mechanism are discussed.http://www.mdpi.com/1999-4915/1/3/1240/herpesvirusnuclear domain 10PML nuclear bodiesPMLSp100hDaxxantiviral defenseintrinsic immunityinterferon |
| spellingShingle | Nina Tavalai Thomas Stamminger Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies Viruses herpesvirus nuclear domain 10 PML nuclear bodies PML Sp100 hDaxx antiviral defense intrinsic immunity interferon |
| title | Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies |
| title_full | Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies |
| title_fullStr | Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies |
| title_full_unstemmed | Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies |
| title_short | Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies |
| title_sort | interplay between herpesvirus infection and host defense by pml nuclear bodies |
| topic | herpesvirus nuclear domain 10 PML nuclear bodies PML Sp100 hDaxx antiviral defense intrinsic immunity interferon |
| url | http://www.mdpi.com/1999-4915/1/3/1240/ |
| work_keys_str_mv | AT ninatavalai interplaybetweenherpesvirusinfectionandhostdefensebypmlnuclearbodies AT thomasstamminger interplaybetweenherpesvirusinfectionandhostdefensebypmlnuclearbodies |