Seroprevalence and indexes of IgG antibodies for SARS-CoV-2 infection among People Living With HIV, tuberculosis patients and healthcare workers, in Salvador, Brazil
Introduction: COVID-19 can trigger different clinical presentations in distinct population groups, some of which are considered at higher risk of SARS-CoV-2 infection. Little is known about the susceptibility of certain populations to the infection. Objectives: We aimed to determine the prevalence o...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Brazilian Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867023000715 |
| _version_ | 1797660549725552640 |
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| author | Daniele Souza de Santana Eduardo Martins Netto Sara Nunes Vaz Paulo Henrique Dantas Carlos Brites |
| author_facet | Daniele Souza de Santana Eduardo Martins Netto Sara Nunes Vaz Paulo Henrique Dantas Carlos Brites |
| author_sort | Daniele Souza de Santana |
| collection | DOAJ |
| description | Introduction: COVID-19 can trigger different clinical presentations in distinct population groups, some of which are considered at higher risk of SARS-CoV-2 infection. Little is known about the susceptibility of certain populations to the infection. Objectives: We aimed to determine the prevalence of COVID-19 among People Living With HIV/AIDS (PLWH) attending a tertiary public hospital in Salvador, Brazil, patients with active pulmonary tuberculosis and Hospital's Healthcare Workers (HCW), and to compare their SARS-CoV-2 antibody levels. Methods: In this observational study we included 2294 participants from June 9, 2020 to August 10, 2021. IgG SARS-CoV-2 antibodies from all participants (275 PLWH, 42 with active tuberculosis and 1977 healthcare workers) were measured. Prevalence of COVID-19 and antibodies indexes were compared across groups. Results: We detected a higher prevalence of COVID-19 in patients with active tuberculosis (42.9%) than in PLWH (22.5%) or HCW (11.7%). Previously vaccinated participants with a COVID-19 history had median higher IgG antibody indexes (8.2; IQR: 5.5‒10) than those vaccinated who did not have COVID-19 until the time of this study (4.1; IQR: 1.6‒6.2, p < 0.001). Conclusion: Prevalence of previous SARS-CoV-2 infection was higher among tuberculosis patients than that found in HCW and PLWH, but antibodies levels were similar across groups. |
| first_indexed | 2024-03-11T18:31:31Z |
| format | Article |
| id | doaj.art-fe877e2ec3c3435191b07caa980d5a03 |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-03-11T18:31:31Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-fe877e2ec3c3435191b07caa980d5a032023-10-13T11:03:51ZengElsevierBrazilian Journal of Infectious Diseases1413-86702023-09-01275102811Seroprevalence and indexes of IgG antibodies for SARS-CoV-2 infection among People Living With HIV, tuberculosis patients and healthcare workers, in Salvador, BrazilDaniele Souza de Santana0Eduardo Martins Netto1Sara Nunes Vaz2Paulo Henrique Dantas3Carlos Brites4Universidade Federal da Bahia (UFBA/EBSERH), Hospital Universitário Professor Edgard Santos, Laboratório de Pesquisa em Infectologia, Salvador, BA, BrazilUniversidade Federal da Bahia (UFBA/EBSERH), Hospital Universitário Professor Edgard Santos, Laboratório de Pesquisa em Infectologia, Salvador, BA, Brazil; Fundação Bahiana de Infectologia, Salvador, BA, BrazilUniversidade Federal da Bahia (UFBA/EBSERH), Hospital Universitário Professor Edgard Santos, Laboratório de Pesquisa em Infectologia, Salvador, BA, Brazil; Fundação Bahiana de Infectologia, Salvador, BA, BrazilUniversidade Federal da Bahia (UFBA/EBSERH), Hospital Universitário Professor Edgard Santos, Laboratório de Pesquisa em Infectologia, Salvador, BA, BrazilUniversidade Federal da Bahia (UFBA/EBSERH), Hospital Universitário Professor Edgard Santos, Laboratório de Pesquisa em Infectologia, Salvador, BA, Brazil; Fundação Bahiana de Infectologia, Salvador, BA, Brazil; Corresponding author.Introduction: COVID-19 can trigger different clinical presentations in distinct population groups, some of which are considered at higher risk of SARS-CoV-2 infection. Little is known about the susceptibility of certain populations to the infection. Objectives: We aimed to determine the prevalence of COVID-19 among People Living With HIV/AIDS (PLWH) attending a tertiary public hospital in Salvador, Brazil, patients with active pulmonary tuberculosis and Hospital's Healthcare Workers (HCW), and to compare their SARS-CoV-2 antibody levels. Methods: In this observational study we included 2294 participants from June 9, 2020 to August 10, 2021. IgG SARS-CoV-2 antibodies from all participants (275 PLWH, 42 with active tuberculosis and 1977 healthcare workers) were measured. Prevalence of COVID-19 and antibodies indexes were compared across groups. Results: We detected a higher prevalence of COVID-19 in patients with active tuberculosis (42.9%) than in PLWH (22.5%) or HCW (11.7%). Previously vaccinated participants with a COVID-19 history had median higher IgG antibody indexes (8.2; IQR: 5.5‒10) than those vaccinated who did not have COVID-19 until the time of this study (4.1; IQR: 1.6‒6.2, p < 0.001). Conclusion: Prevalence of previous SARS-CoV-2 infection was higher among tuberculosis patients than that found in HCW and PLWH, but antibodies levels were similar across groups.http://www.sciencedirect.com/science/article/pii/S1413867023000715SARS-CoV-2SerologyHIVTuberculosis |
| spellingShingle | Daniele Souza de Santana Eduardo Martins Netto Sara Nunes Vaz Paulo Henrique Dantas Carlos Brites Seroprevalence and indexes of IgG antibodies for SARS-CoV-2 infection among People Living With HIV, tuberculosis patients and healthcare workers, in Salvador, Brazil Brazilian Journal of Infectious Diseases SARS-CoV-2 Serology HIV Tuberculosis |
| title | Seroprevalence and indexes of IgG antibodies for SARS-CoV-2 infection among People Living With HIV, tuberculosis patients and healthcare workers, in Salvador, Brazil |
| title_full | Seroprevalence and indexes of IgG antibodies for SARS-CoV-2 infection among People Living With HIV, tuberculosis patients and healthcare workers, in Salvador, Brazil |
| title_fullStr | Seroprevalence and indexes of IgG antibodies for SARS-CoV-2 infection among People Living With HIV, tuberculosis patients and healthcare workers, in Salvador, Brazil |
| title_full_unstemmed | Seroprevalence and indexes of IgG antibodies for SARS-CoV-2 infection among People Living With HIV, tuberculosis patients and healthcare workers, in Salvador, Brazil |
| title_short | Seroprevalence and indexes of IgG antibodies for SARS-CoV-2 infection among People Living With HIV, tuberculosis patients and healthcare workers, in Salvador, Brazil |
| title_sort | seroprevalence and indexes of igg antibodies for sars cov 2 infection among people living with hiv tuberculosis patients and healthcare workers in salvador brazil |
| topic | SARS-CoV-2 Serology HIV Tuberculosis |
| url | http://www.sciencedirect.com/science/article/pii/S1413867023000715 |
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