A Semi Rigid Novel Hydroxamate AMPED-Based Ligand for <sup>89</sup>Zr PET Imaging

A Semi Rigid Novel Hydroxamate AMPED-Based Ligand for <sup>89</sup>Zr PET Imaging

In this work, we designed, developed, characterized, and investigated a new chelator and its bifunctional derivative for <sup>89</sup>Zr labeling and PET-imaging. In a preliminary study, we synthesized two hexadentate chelators named AAZTHAS and AAZTHAG, based on the seven-membered heter...

Full description

Bibliographic Details
Main Authors:	Lisa Russelli, Francesco De Rose, Loredana Leone, Sybille Reder, Markus Schwaiger, Calogero D’Alessandria, Lorenzo Tei
Format:	Article
Language:	English
Published:	MDPI AG 2021-09-01
Series:	Molecules
Subjects:	zirconium-89 polydentate chelators hydroxamates PET-imaging labeling
Online Access:	https://www.mdpi.com/1420-3049/26/19/5819

Similar Items

Purification of 89Zr by Hydroxamate-Based Resins
by: Li-qiang WANG, et al.
Published: (2024-12-01)

Production and Semi-Automated Processing of <sup>89</sup>Zr Using a Commercially Available TRASIS MiniAiO Module
by: Vijay Gaja, et al.
Published: (2020-06-01)

Recent Advances in Zirconium-89 Chelator Development
by: Nikunj B. Bhatt, et al.
Published: (2018-03-01)

Automated synthesis of [89Zr]ZrCl4, [89Zr]ZrDFOSquaramide-bisPh(PSMA) and [89Zr]ZrDFOSquaramide-TATE
by: Asif Noor, et al.
Published: (2024-05-01)

From Bench to Bedside: Patient-Oriented Radiopharmaceutical Development in Nuclear Medicine Based on the Example of [<sup>89</sup>Zr]Zr-PSMA-DFO
by: Klaus Schomäcker, et al.
Published: (2023-12-01)

In Vitro and In Vivo Characterization of <sup>89</sup>Zirconium-Labeled Lintuzumab Molecule
by: Kevin J. H. Allen, et al.
Published: (2022-10-01)

Good practices for 89Zr radiopharmaceutical production and quality control
by: Thomas Erik Wuensche, et al.
Published: (2024-05-01)

Bifunctional octadentate pseudopeptides as Zirconium-89 chelators for immuno-PET applications
by: Valentina Albanese, et al.
Published: (2024-05-01)

Preclinical evaluation and automated synthesis of [89Zr]ZrDFOSquaramide-girentuximab for diagnostic imaging of carbonic anhydrase IX positive tumours
by: Asif Noor, et al.
Published: (2024-11-01)

Thermodynamic and Kinetic Stabilities of Al(III) Complexes with N<sub>2</sub>O<sub>3</sub> Pentadentate Ligands
by: Edoardo Callegari, et al.
Published: (2023-04-01)

<sup>89</sup>Zr-Labeled AR20.5: A MUC1-Targeting ImmunoPET Probe
by: Kimberly Fung, et al.
Published: (2020-05-01)

Semi-Rigid (Aminomethyl) Piperidine-Based Pentadentate Ligands for Mn(II) Complexation
by: Jonathan Martinelli, et al.
Published: (2021-10-01)

A generic 89Zr labeling method to quantify the in vivo pharmacokinetics of liposomal nanoparticles with positron emission tomography
by: Li N, et al.
Published: (2017-04-01)

Bone marrow cell homing to sites of acute tibial fracture: 89Zr-oxine cell labeling with positron emission tomographic imaging in a mouse model
by: Kingsley O. Asiedu, et al.
Published: (2018-12-01)

Preparation of Zirconium-89 Solutions for Radiopharmaceutical Purposes: Interrelation Between Formulation, Radiochemical Purity, Stability and Biodistribution
by: Anton Larenkov, et al.
Published: (2019-04-01)

89Zr-leukocyte labelling for cell trafficking: in vitro and preclinical investigations
by: Maryke Kahts, et al.
Published: (2023-11-01)

Toward Optimized <sup>89</sup>Zr-Immuno-PET: Side-by-Side Comparison of [<sup>89</sup>Zr]Zr-DFO-, [<sup>89</sup>Zr]Zr-3,4,3-(LI-1,2-HOPO)- and [<sup>89</sup>Zr]Zr-DFO*-Cetuximab for Tumor Imaging: Which Chelator Is the Most Suitable?
by: Helen Damerow, et al.
Published: (2022-10-01)

N-Based Polydentate Ligands and Corresponding Zn(II) Complexes: A Structural and Spectroscopic Study
by: Giorgio Volpi, et al.
Published: (2023-11-01)

Non-specific irreversible 89Zr-mAb uptake in tumours: evidence from biopsy-proven target-negative tumours using 89Zr-immuno-PET
by: Jessica E. Wijngaarden, et al.
Published: (2024-02-01)

Rational Design, Synthesis and Preliminary Evaluation of Novel Fusarinine C-Based Chelators for Radiolabeling with Zirconium-89
by: Chuangyan Zhai, et al.
Published: (2019-03-01)

Preclinical Pharmacokinetics and Dosimetry of an 89Zr Labelled Anti-PDL1 in an Orthotopic Lung Cancer Murine Model
by: Anis Krache, et al.
Published: (2022-01-01)

Detection limit of 89Zr-labeled T cells for cellular tracking: an in vitro imaging approach using clinical PET/CT and PET/MRI
by: Laura M. Lechermann, et al.
Published: (2020-07-01)

Preclinical PET and MR Evaluation of <sup>89</sup>Zr- and <sup>68</sup>Ga-Labeled Nanodiamonds in Mice over Different Time Scales
by: Gordon Winter, et al.
Published: (2022-12-01)

In vivo amyloid-β imaging in the APPPS1-21 transgenic mouse model with a 89Zr- labeled monoclonal antibody.
by: Ann-Marie eWaldron, et al.
Published: (2016-03-01)

Preparation of 89Zr by Cyclotron and its Purification and Labeling Methods
by: XU Zhiyu1, 2, YANG Dacan3, WANG Guixiang1, 2, CHENG Wanting3, WANG Fengqing3, MA Fuqiu1, 2
Published: (2024-04-01)

Isolation and Bioactivity of Natural Products from <i>Streptomyces</i> sp. MA37
by: Fleurdeliz Maglangit, et al.
Published: (2025-01-01)

Biodistribution of Mesenchymal Stromal Cells Labeled with [<sup>89</sup>Zr]Zr-Oxine in Local Radiation Injuries in Laboratory Animals
by: Tatiana A. Astrelina, et al.
Published: (2023-10-01)

Quantitative Biodistribution and Pharmacokinetics Study of GMP-Grade Exosomes Labeled with <sup>89</sup>Zr Radioisotope in Mice and Rats
by: Hojun Choi, et al.
Published: (2022-05-01)

[<sup>89</sup>Zr]Zr-PSMA-617 PET/CT in a Patient with Biochemical Recurrence of Prostate Cancer and Prior Indetermined Findings on [<sup>18</sup>F]PSMA-1007 Imaging
by: Moritz B. Bastian, et al.
Published: (2024-10-01)

89Zr-labeled ImmunoPET targeting the cancer stem cell antigen CD133 using fully-human antibody constructs
by: Kevin Wyszatko, et al.
Published: (2024-03-01)

Thin-layer chromatography of hydroxamic acids
by: Eberhardg G. Trams
Published: (1967-11-01)

Synthesis and structure-activity relationships of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives as 5-lipoxygenase inhibitors
by: Oludotun A. Phillips, et al.
Published: (2020-01-01)

Enzymatic Synthesis of Fatty Hydroxamic Acid Derivatives Based on Palm Kernel Oil
by: Sidik Silong, et al.
Published: (2011-08-01)

Production Process of 89Zr Based on C30 Cyclotron
by: WEN Kai1,2,3, DUAN Fei1,2,3, LI Guang1,2,3, MA Chengwei1,2,3, WANG Xiaoming1,2,3, ZHAO Ziyu1,2,3, CHU Haomiao1,2,3, LI Chao1,2,3, WANG Chengzhi1,2,3, WANG Chunlin1,2,3
Published: (2024-05-01)

Immuno-PET Imaging of Atherosclerotic Plaques with [<sup>89</sup>Zr]Zr-Anti-CD40 mAb—Proof of Concept
by: Kikkie Poels, et al.
Published: (2022-03-01)

3D Convolutional Neural Network-Based Denoising of Low-Count Whole-Body <sup>18</sup>F-Fluorodeoxyglucose and <sup>89</sup>Zr-Rituximab PET Scans
by: Bart M. de Vries, et al.
Published: (2022-02-01)

Re-Evaluations of Zr-DFO Complex Coordination Chemistry for the Estimation of Radiochemical Yields and Chelator-to-Antibody Ratios of <sup>89</sup>Zr Immune-PET Tracers
by: Ryota Imura, et al.
Published: (2021-08-01)

Comparative Study with 89Y-foil and 89Y-pressed Targets for the Production of 89Zr †
by: Aiman H. Alnahwi, et al.
Published: (2018-09-01)

Outstanding increase in tumor-to-background ratio over time allows tumor localization by [89Zr]Zr-PSMA-617 PET/CT in early biochemical recurrence of prostate cancer
by: Caroline Burgard, et al.
Published: (2024-10-01)

Crystal Structures of a Series of Hydroxamic Acids
by: Ibrahima Sory Sow, et al.
Published: (2023-05-01)