Molecular and Biomechanical Adaptations to Mechanical Stretch in Cultured Myotubes
Myotubes are mature muscle cells that form the basic structural element of skeletal muscle. When stretching skeletal muscles, myotubes are subjected to passive tension as well. This lead to alterations in myotube cytophysiology, which could be related with muscular biomechanics. During the past deca...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.689492/full |
| _version_ | 1819137040968581120 |
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| author | Dapeng Ren Dapeng Ren Jing Song Ran Liu Xuemin Zeng Xuemin Zeng Xiao Yan Qiang Zhang Xiao Yuan |
| author_facet | Dapeng Ren Dapeng Ren Jing Song Ran Liu Xuemin Zeng Xuemin Zeng Xiao Yan Qiang Zhang Xiao Yuan |
| author_sort | Dapeng Ren |
| collection | DOAJ |
| description | Myotubes are mature muscle cells that form the basic structural element of skeletal muscle. When stretching skeletal muscles, myotubes are subjected to passive tension as well. This lead to alterations in myotube cytophysiology, which could be related with muscular biomechanics. During the past decades, much progresses have been made in exploring biomechanical properties of myotubes in vitro. In this review, we integrated the studies focusing on cultured myotubes being mechanically stretched, and classified these studies into several categories: amino acid and glucose uptake, protein turnover, myotube hypertrophy and atrophy, maturation, alignment, secretion of cytokines, cytoskeleton adaption, myotube damage, ion channel activation, and oxidative stress in myotubes. These biomechanical adaptions do not occur independently, but interconnect with each other as part of the systematic mechanoresponse of myotubes. The purpose of this review is to broaden our comprehensions of stretch-induced muscular alterations in cellular and molecular scales, and to point out future challenges and directions in investigating myotube biomechanical manifestations. |
| first_indexed | 2024-12-22T10:44:33Z |
| format | Article |
| id | doaj.art-fe8a051d444e4e668887557b1f86b2af |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-22T10:44:33Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-fe8a051d444e4e668887557b1f86b2af2022-12-21T18:28:59ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-08-011210.3389/fphys.2021.689492689492Molecular and Biomechanical Adaptations to Mechanical Stretch in Cultured MyotubesDapeng Ren0Dapeng Ren1Jing Song2Ran Liu3Xuemin Zeng4Xuemin Zeng5Xiao Yan6Qiang Zhang7Xiao Yuan8Department of Stomatology Medical Center, The Affiliated Hospital of Qingdao University, Qingdao, ChinaCollege of Dentistry, Qingdao University, Qingdao, ChinaDepartment of Stomatology Medical Center, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Stomatology Medical Center, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Stomatology Medical Center, The Affiliated Hospital of Qingdao University, Qingdao, ChinaCollege of Dentistry, Qingdao University, Qingdao, ChinaDepartment of Stomatology Medical Center, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Stomatology Medical Center, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Stomatology Medical Center, The Affiliated Hospital of Qingdao University, Qingdao, ChinaMyotubes are mature muscle cells that form the basic structural element of skeletal muscle. When stretching skeletal muscles, myotubes are subjected to passive tension as well. This lead to alterations in myotube cytophysiology, which could be related with muscular biomechanics. During the past decades, much progresses have been made in exploring biomechanical properties of myotubes in vitro. In this review, we integrated the studies focusing on cultured myotubes being mechanically stretched, and classified these studies into several categories: amino acid and glucose uptake, protein turnover, myotube hypertrophy and atrophy, maturation, alignment, secretion of cytokines, cytoskeleton adaption, myotube damage, ion channel activation, and oxidative stress in myotubes. These biomechanical adaptions do not occur independently, but interconnect with each other as part of the systematic mechanoresponse of myotubes. The purpose of this review is to broaden our comprehensions of stretch-induced muscular alterations in cellular and molecular scales, and to point out future challenges and directions in investigating myotube biomechanical manifestations.https://www.frontiersin.org/articles/10.3389/fphys.2021.689492/fullmyotubemechanical stretchbiomechanical adaptationmechanoresponseskeletal muscle |
| spellingShingle | Dapeng Ren Dapeng Ren Jing Song Ran Liu Xuemin Zeng Xuemin Zeng Xiao Yan Qiang Zhang Xiao Yuan Molecular and Biomechanical Adaptations to Mechanical Stretch in Cultured Myotubes Frontiers in Physiology myotube mechanical stretch biomechanical adaptation mechanoresponse skeletal muscle |
| title | Molecular and Biomechanical Adaptations to Mechanical Stretch in Cultured Myotubes |
| title_full | Molecular and Biomechanical Adaptations to Mechanical Stretch in Cultured Myotubes |
| title_fullStr | Molecular and Biomechanical Adaptations to Mechanical Stretch in Cultured Myotubes |
| title_full_unstemmed | Molecular and Biomechanical Adaptations to Mechanical Stretch in Cultured Myotubes |
| title_short | Molecular and Biomechanical Adaptations to Mechanical Stretch in Cultured Myotubes |
| title_sort | molecular and biomechanical adaptations to mechanical stretch in cultured myotubes |
| topic | myotube mechanical stretch biomechanical adaptation mechanoresponse skeletal muscle |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.689492/full |
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