Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets

Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets

Platelet function at vascular injury sites is tightly regulated through the actin cytoskeleton. The Wiskott–Aldrich syndrome protein-family verprolin-homologous protein (WAVE)-regulatory complex (WRC) activates lamellipodia formation via ARP2/3, initiated by GTP-bound RAC1 interacting with the WRC s...

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Bibliographic Details
Main Authors: Dmitri Sisario, Markus Spindler, Katharina J. Ermer, Noah Grütz, Leo Nicolai, Florian Gaertner, Laura M. Machesky, Markus Bender
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cells
Subjects:
platelets
FAM49b
CYRI-B
RAC1
actin
CYFIP1
Online Access:https://www.mdpi.com/2073-4409/13/4/299

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