Subsequent and simultaneous electrophysiological investigation of the retina and the visual cortex in neurodegenerative and psychiatric diseases: what are the forecasts for the medicine of tomorrow?
Visual electrophysiological deficits have been reported in neurodegenerative disorders as well as in mental disorders. Such alterations have been mentioned in both the retina and the cortex, notably affecting the photoreceptors, retinal ganglion cells (RGCs) and the primary visual cortex. Interestin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1167654/full |
| _version_ | 1797813633331232768 |
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| author | Katelyne Tursini Katelyne Tursini Katelyne Tursini Irving Remy Irving Remy Irving Remy Steven Le Cam Valérie Louis-Dorr Hélène Malka-Mahieu Raymund Schwan Raymund Schwan Raymund Schwan Grégory Gross Grégory Gross Vincent Laprévote Vincent Laprévote Vincent Laprévote Thomas Schwitzer Thomas Schwitzer Thomas Schwitzer |
| author_facet | Katelyne Tursini Katelyne Tursini Katelyne Tursini Irving Remy Irving Remy Irving Remy Steven Le Cam Valérie Louis-Dorr Hélène Malka-Mahieu Raymund Schwan Raymund Schwan Raymund Schwan Grégory Gross Grégory Gross Vincent Laprévote Vincent Laprévote Vincent Laprévote Thomas Schwitzer Thomas Schwitzer Thomas Schwitzer |
| author_sort | Katelyne Tursini |
| collection | DOAJ |
| description | Visual electrophysiological deficits have been reported in neurodegenerative disorders as well as in mental disorders. Such alterations have been mentioned in both the retina and the cortex, notably affecting the photoreceptors, retinal ganglion cells (RGCs) and the primary visual cortex. Interestingly, such impairments emphasize the functional role of the visual system. For this purpose, the present study reviews the existing literature with the aim of identifying key alterations in electroretinograms (ERGs) and visual evoked potentials electroencephalograms (VEP-EEGs) of subjects with neurodegenerative and psychiatric disorders. We focused on psychiatric and neurodegenerative diseases due to similarities in their neuropathophysiological mechanisms. Our research focuses on decoupled and coupled ERG/VEP-EEG results obtained with black-and-white checkerboards or low-level visual stimuli. A decoupled approach means recording first the ERG, then the VEP-EEG in the same subject with the same visual stimuli. The second method means recording both ERG and VEP-EEG simultaneously in the same participant with the same visual stimuli. Both coupled and decoupled results were found, indicating deficits mainly in the N95 ERG wave and the P100 VEP-EEG wave in Parkinson’s, Alzheimer’s, and major depressive disorder. Such results reinforce the link between the retina and the visual cortex for the diagnosis of psychiatric and neurodegenerative diseases. With that in mind, medical devices using coupled ERG/VEP-EEG measurements are being developed in order to further investigate the relationship between the retina and the visual cortex. These new techniques outline future challenges in mental health and the use of machine learning for the diagnosis of mental disorders, which would be a crucial step toward precision psychiatry. |
| first_indexed | 2024-03-13T07:55:40Z |
| format | Article |
| id | doaj.art-fe8af1655670427ab7e54364451d219d |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-03-13T07:55:40Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-fe8af1655670427ab7e54364451d219d2023-06-02T06:07:13ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-06-011410.3389/fpsyt.2023.11676541167654Subsequent and simultaneous electrophysiological investigation of the retina and the visual cortex in neurodegenerative and psychiatric diseases: what are the forecasts for the medicine of tomorrow?Katelyne Tursini0Katelyne Tursini1Katelyne Tursini2Irving Remy3Irving Remy4Irving Remy5Steven Le Cam6Valérie Louis-Dorr7Hélène Malka-Mahieu8Raymund Schwan9Raymund Schwan10Raymund Schwan11Grégory Gross12Grégory Gross13Vincent Laprévote14Vincent Laprévote15Vincent Laprévote16Thomas Schwitzer17Thomas Schwitzer18Thomas Schwitzer19Pôle Hospitalo-Universitaire de Psychiatrie d’Adultes et d’Addictologie du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, FranceBioSerenity, Paris, FranceINSERM U1254, Université de Lorraine, IADI, Nancy, FrancePôle Hospitalo-Universitaire de Psychiatrie d’Adultes et d’Addictologie du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, FranceBioSerenity, Paris, FranceINSERM U1114, Université de Strasbourg, Strasbourg, FranceCRAN, CNRS UMR 7039, Université de Lorraine, Nancy, FranceCRAN, CNRS UMR 7039, Université de Lorraine, Nancy, FranceBioSerenity, Paris, FrancePôle Hospitalo-Universitaire de Psychiatrie d’Adultes et d’Addictologie du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, FranceINSERM U1254, Université de Lorraine, IADI, Nancy, FranceFaculté de Médecine, Université de Lorraine, Vandœuvre-lès-Nancy, FrancePôle Hospitalo-Universitaire de Psychiatrie d’Adultes et d’Addictologie du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, FranceINSERM U1254, Université de Lorraine, IADI, Nancy, FrancePôle Hospitalo-Universitaire de Psychiatrie d’Adultes et d’Addictologie du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, FranceINSERM U1114, Université de Strasbourg, Strasbourg, FranceFaculté de Médecine, Université de Lorraine, Vandœuvre-lès-Nancy, FrancePôle Hospitalo-Universitaire de Psychiatrie d’Adultes et d’Addictologie du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, FranceINSERM U1254, Université de Lorraine, IADI, Nancy, FranceFaculté de Médecine, Université de Lorraine, Vandœuvre-lès-Nancy, FranceVisual electrophysiological deficits have been reported in neurodegenerative disorders as well as in mental disorders. Such alterations have been mentioned in both the retina and the cortex, notably affecting the photoreceptors, retinal ganglion cells (RGCs) and the primary visual cortex. Interestingly, such impairments emphasize the functional role of the visual system. For this purpose, the present study reviews the existing literature with the aim of identifying key alterations in electroretinograms (ERGs) and visual evoked potentials electroencephalograms (VEP-EEGs) of subjects with neurodegenerative and psychiatric disorders. We focused on psychiatric and neurodegenerative diseases due to similarities in their neuropathophysiological mechanisms. Our research focuses on decoupled and coupled ERG/VEP-EEG results obtained with black-and-white checkerboards or low-level visual stimuli. A decoupled approach means recording first the ERG, then the VEP-EEG in the same subject with the same visual stimuli. The second method means recording both ERG and VEP-EEG simultaneously in the same participant with the same visual stimuli. Both coupled and decoupled results were found, indicating deficits mainly in the N95 ERG wave and the P100 VEP-EEG wave in Parkinson’s, Alzheimer’s, and major depressive disorder. Such results reinforce the link between the retina and the visual cortex for the diagnosis of psychiatric and neurodegenerative diseases. With that in mind, medical devices using coupled ERG/VEP-EEG measurements are being developed in order to further investigate the relationship between the retina and the visual cortex. These new techniques outline future challenges in mental health and the use of machine learning for the diagnosis of mental disorders, which would be a crucial step toward precision psychiatry.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1167654/fullERG = electroretinogramEEGVEP = visual evoked potentialpsychiatryneurodegenerative diseaseretina |
| spellingShingle | Katelyne Tursini Katelyne Tursini Katelyne Tursini Irving Remy Irving Remy Irving Remy Steven Le Cam Valérie Louis-Dorr Hélène Malka-Mahieu Raymund Schwan Raymund Schwan Raymund Schwan Grégory Gross Grégory Gross Vincent Laprévote Vincent Laprévote Vincent Laprévote Thomas Schwitzer Thomas Schwitzer Thomas Schwitzer Subsequent and simultaneous electrophysiological investigation of the retina and the visual cortex in neurodegenerative and psychiatric diseases: what are the forecasts for the medicine of tomorrow? Frontiers in Psychiatry ERG = electroretinogram EEG VEP = visual evoked potential psychiatry neurodegenerative disease retina |
| title | Subsequent and simultaneous electrophysiological investigation of the retina and the visual cortex in neurodegenerative and psychiatric diseases: what are the forecasts for the medicine of tomorrow? |
| title_full | Subsequent and simultaneous electrophysiological investigation of the retina and the visual cortex in neurodegenerative and psychiatric diseases: what are the forecasts for the medicine of tomorrow? |
| title_fullStr | Subsequent and simultaneous electrophysiological investigation of the retina and the visual cortex in neurodegenerative and psychiatric diseases: what are the forecasts for the medicine of tomorrow? |
| title_full_unstemmed | Subsequent and simultaneous electrophysiological investigation of the retina and the visual cortex in neurodegenerative and psychiatric diseases: what are the forecasts for the medicine of tomorrow? |
| title_short | Subsequent and simultaneous electrophysiological investigation of the retina and the visual cortex in neurodegenerative and psychiatric diseases: what are the forecasts for the medicine of tomorrow? |
| title_sort | subsequent and simultaneous electrophysiological investigation of the retina and the visual cortex in neurodegenerative and psychiatric diseases what are the forecasts for the medicine of tomorrow |
| topic | ERG = electroretinogram EEG VEP = visual evoked potential psychiatry neurodegenerative disease retina |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1167654/full |
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