The role of Axin2+ cells in periodontal tissue development and regeneration
As a highly conserved signal pathway in evolution, the WNT signaling pathway plays an essential role in periodontium growth, development and injury repair. The Axin-associated protein Axin2 is a direct effector molecule of the WNT signaling pathway and labels WNT-responsive cells well. Studies have...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
2022-06-01
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| Series: | 口腔疾病防治 |
| Subjects: | |
| Online Access: | http://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2022.06.008 |
| _version_ | 1811300100224319488 |
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| author | SHI Binmian XIE Xudong WANG Jun |
| author_facet | SHI Binmian XIE Xudong WANG Jun |
| author_sort | SHI Binmian |
| collection | DOAJ |
| description | As a highly conserved signal pathway in evolution, the WNT signaling pathway plays an essential role in periodontium growth, development and injury repair. The Axin-associated protein Axin2 is a direct effector molecule of the WNT signaling pathway and labels WNT-responsive cells well. Studies have shown that Axin2-positive (Axin2+) cells in the periodontium have the potential for self-renewal, replication and multidirectional differentiation. This article reviews the temporal and spatial distribution of Axin2+ cells in periodontal tissue development and the role and regulatory mechanism of Axin2+ cells in periodontal tissue development, regeneration and tissue remodeling to provide new ideas for periodontal tissue regeneration. The literature review showed that Axin2+ cells were the main cell source of periodontium development, and Axin2+ cells played essential roles in tooth extraction socket healing, implant osseointegration, periodontal tissue remodeling and junctional epithelium regeneration. The function of Axin2+ cells was positively regulated by the canonical WNT signaling pathway. However, the regulatory mechanisms of other signaling pathways on Axin2+ cells remain to be elucidated. |
| first_indexed | 2024-04-13T06:46:14Z |
| format | Article |
| id | doaj.art-fe8b2f292dd24d5ab2d1b4905e486e95 |
| institution | Directory Open Access Journal |
| issn | 2096-1456 |
| language | zho |
| last_indexed | 2024-04-13T06:46:14Z |
| publishDate | 2022-06-01 |
| publisher | Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases |
| record_format | Article |
| series | 口腔疾病防治 |
| spelling | doaj.art-fe8b2f292dd24d5ab2d1b4905e486e952022-12-22T02:57:35ZzhoEditorial Department of Journal of Prevention and Treatment for Stomatological Diseases口腔疾病防治2096-14562022-06-0130643343710.12016/j.issn.2096-1456.2022.06.008The role of Axin2+ cells in periodontal tissue development and regenerationSHI Binmian0 XIE Xudong1WANG Jun2State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Periodontics, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Periodontics, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Periodontics, West China Hospital of Stomatology, Sichuan UniversityAs a highly conserved signal pathway in evolution, the WNT signaling pathway plays an essential role in periodontium growth, development and injury repair. The Axin-associated protein Axin2 is a direct effector molecule of the WNT signaling pathway and labels WNT-responsive cells well. Studies have shown that Axin2-positive (Axin2+) cells in the periodontium have the potential for self-renewal, replication and multidirectional differentiation. This article reviews the temporal and spatial distribution of Axin2+ cells in periodontal tissue development and the role and regulatory mechanism of Axin2+ cells in periodontal tissue development, regeneration and tissue remodeling to provide new ideas for periodontal tissue regeneration. The literature review showed that Axin2+ cells were the main cell source of periodontium development, and Axin2+ cells played essential roles in tooth extraction socket healing, implant osseointegration, periodontal tissue remodeling and junctional epithelium regeneration. The function of Axin2+ cells was positively regulated by the canonical WNT signaling pathway. However, the regulatory mechanisms of other signaling pathways on Axin2+ cells remain to be elucidated.http://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2022.06.008wnt signaling pathwayaxin2periodontal tissuesdevelopmentregenerationstem cellhomeostasiscelllineage tracing |
| spellingShingle | SHI Binmian XIE Xudong WANG Jun The role of Axin2+ cells in periodontal tissue development and regeneration 口腔疾病防治 wnt signaling pathway axin2 periodontal tissues development regeneration stem cell homeostasis celllineage tracing |
| title | The role of Axin2+ cells in periodontal tissue development and regeneration |
| title_full | The role of Axin2+ cells in periodontal tissue development and regeneration |
| title_fullStr | The role of Axin2+ cells in periodontal tissue development and regeneration |
| title_full_unstemmed | The role of Axin2+ cells in periodontal tissue development and regeneration |
| title_short | The role of Axin2+ cells in periodontal tissue development and regeneration |
| title_sort | role of axin2 cells in periodontal tissue development and regeneration |
| topic | wnt signaling pathway axin2 periodontal tissues development regeneration stem cell homeostasis celllineage tracing |
| url | http://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2022.06.008 |
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