Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver

Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver

Nutrient availability fluctuates in most natural populations, forcing organisms to undergo periods of fasting and re-feeding. It is unknown how dietary changes influence liver homeostasis. Here, we show that a switch from ad libitum feeding to intermittent fasting (IF) promotes rapid hepatocyte prol...

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Bibliographic Details
Main Authors: Abby Sarkar, Yinhua Jin, Brian C DeFelice, Catriona Y Logan, Yan Yang, Teni Anbarchian, Peng Wu, Maurizio Morri, Norma F Neff, Huy Nguyen, Eric Rulifson, Matthew Fish, Avi Gurion Kaye, Azalia M Martínez Jaimes, Roel Nusse
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-01-01
Series:eLife
Subjects:
liver
regeneration
intermittent fasting
Online Access:https://elifesciences.org/articles/82311

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