Oncogenic β-catenin mutations evade pH-regulated degradation
β-catenin has roles in cell-cell adhesion and Wnt signaling. We recently showed that β-catenin protein abundance is decreased at higher intracellular pH (pHi), mediated by pH-sensitive interaction with the beta-transducin repeat containing E3 ubiquitin protein ligase (β-TrCP). Increased pHi facilita...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-01-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2018.1554470 |
| _version_ | 1797677185814757376 |
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| author | Bree K. Grillo-Hill Katharine A. White |
| author_facet | Bree K. Grillo-Hill Katharine A. White |
| author_sort | Bree K. Grillo-Hill |
| collection | DOAJ |
| description | β-catenin has roles in cell-cell adhesion and Wnt signaling. We recently showed that β-catenin protein abundance is decreased at higher intracellular pH (pHi), mediated by pH-sensitive interaction with the beta-transducin repeat containing E3 ubiquitin protein ligase (β-TrCP). Increased pHi facilitates β-TrCP binding and degradation of β-catenin. β-catenin mutations that abrogate the pH-sensitive interaction induce significant tumors not seen with other β-catenin stabilizing mutants. |
| first_indexed | 2024-03-11T22:41:23Z |
| format | Article |
| id | doaj.art-fe8e666f03e0458a9c2d5064be93e254 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:23Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-fe8e666f03e0458a9c2d5064be93e2542023-09-22T09:11:00ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562019-01-016110.1080/23723556.2018.15544701554470Oncogenic β-catenin mutations evade pH-regulated degradationBree K. Grillo-Hill0Katharine A. White1San Jose State UniversityUniversity of California, San Franciscoβ-catenin has roles in cell-cell adhesion and Wnt signaling. We recently showed that β-catenin protein abundance is decreased at higher intracellular pH (pHi), mediated by pH-sensitive interaction with the beta-transducin repeat containing E3 ubiquitin protein ligase (β-TrCP). Increased pHi facilitates β-TrCP binding and degradation of β-catenin. β-catenin mutations that abrogate the pH-sensitive interaction induce significant tumors not seen with other β-catenin stabilizing mutants.http://dx.doi.org/10.1080/23723556.2018.1554470β-cateninintracellular phwnt signalingubiquitinationproteasomeβ-trcptumorigenesis |
| spellingShingle | Bree K. Grillo-Hill Katharine A. White Oncogenic β-catenin mutations evade pH-regulated degradation Molecular & Cellular Oncology β-catenin intracellular ph wnt signaling ubiquitination proteasome β-trcp tumorigenesis |
| title | Oncogenic β-catenin mutations evade pH-regulated degradation |
| title_full | Oncogenic β-catenin mutations evade pH-regulated degradation |
| title_fullStr | Oncogenic β-catenin mutations evade pH-regulated degradation |
| title_full_unstemmed | Oncogenic β-catenin mutations evade pH-regulated degradation |
| title_short | Oncogenic β-catenin mutations evade pH-regulated degradation |
| title_sort | oncogenic β catenin mutations evade ph regulated degradation |
| topic | β-catenin intracellular ph wnt signaling ubiquitination proteasome β-trcp tumorigenesis |
| url | http://dx.doi.org/10.1080/23723556.2018.1554470 |
| work_keys_str_mv | AT breekgrillohill oncogenicbcateninmutationsevadephregulateddegradation AT katharineawhite oncogenicbcateninmutationsevadephregulateddegradation |