Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance.

Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance.

SIRT1 is a NAD+-dependent deacetylase thought to regulate cellular metabolic pathways in response to alterations in nutrient flux. In the current study we investigated whether acute changes in SIRT1 expression affect markers of muscle mitochondrial content and also determined whether SIRT1 influence...

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Bibliographic Details
Main Authors: Amanda E Brandon, Jennifer Tid-Ang, Lauren E Wright, Ella Stuart, Eurwin Suryana, Nicholas Bentley, Nigel Turner, Gregory J Cooney, Neil B Ruderman, Edward W Kraegen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4370576?pdf=render

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