Sleep spindles in primates: Modeling the effects of distinct laminar thalamocortical connectivity in core, matrix, and reticular thalamic circuits
AbstractSleep spindles are associated with the beginning of deep sleep and memory consolidation and are disrupted in schizophrenia and autism. In primates, distinct core and matrix thalamocortical (TC) circuits regulate sleep spindle activity through communications that are filtered...
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| Format: | Article |
| Language: | English |
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The MIT Press
2023-01-01
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| Series: | Network Neuroscience |
| Online Access: | https://direct.mit.edu/netn/article/7/2/743/115199/Sleep-spindles-in-primates-Modeling-the-effects-of |
| _version_ | 1797796701396795392 |
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| author | Arash Yazdanbakhsh Helen Barbas Basilis Zikopoulos |
| author_facet | Arash Yazdanbakhsh Helen Barbas Basilis Zikopoulos |
| author_sort | Arash Yazdanbakhsh |
| collection | DOAJ |
| description |
AbstractSleep spindles are associated with the beginning of deep sleep and memory consolidation and are disrupted in schizophrenia and autism. In primates, distinct core and matrix thalamocortical (TC) circuits regulate sleep spindle activity through communications that are filtered by the inhibitory thalamic reticular nucleus (TRN); however, little is known about typical TC network interactions and the mechanisms that are disrupted in brain disorders. We developed a primate-specific, circuit-based TC computational model with distinct core and matrix loops that can simulate sleep spindles. We implemented novel multilevel cortical and thalamic mixing, and included local thalamic inhibitory interneurons, and direct layer 5 projections of variable density to TRN and thalamus to investigate the functional consequences of different ratios of core and matrix node connectivity contribution to spindle dynamics. Our simulations showed that spindle power in primates can be modulated based on the level of cortical feedback, thalamic inhibition, and engagement of model core versus matrix, with the latter having a greater role in spindle dynamics. The study of the distinct spatial and temporal dynamics of core-, matrix-, and mix-generated sleep spindles establishes a framework to study disruption of TC circuit balance underlying deficits in sleep and attentional gating seen in autism and schizophrenia. |
| first_indexed | 2024-03-13T03:37:01Z |
| format | Article |
| id | doaj.art-fe8fc370063c45f8a745db03091ec61d |
| institution | Directory Open Access Journal |
| issn | 2472-1751 |
| language | English |
| last_indexed | 2024-03-13T03:37:01Z |
| publishDate | 2023-01-01 |
| publisher | The MIT Press |
| record_format | Article |
| series | Network Neuroscience |
| spelling | doaj.art-fe8fc370063c45f8a745db03091ec61d2023-06-23T18:42:32ZengThe MIT PressNetwork Neuroscience2472-17512023-01-017274376810.1162/netn_a_00311Sleep spindles in primates: Modeling the effects of distinct laminar thalamocortical connectivity in core, matrix, and reticular thalamic circuitsArash Yazdanbakhsh0http://orcid.org/0000-0003-2792-6770Helen Barbas1Basilis Zikopoulos2http://orcid.org/0000-0002-8834-5104Computational Neuroscience and Vision Lab, Department of Psychological and Brain Sciences, Boston University, Boston, MA, USAGraduate Program for Neuroscience, Boston University, Boston, MA, USAGraduate Program for Neuroscience, Boston University, Boston, MA, USA AbstractSleep spindles are associated with the beginning of deep sleep and memory consolidation and are disrupted in schizophrenia and autism. In primates, distinct core and matrix thalamocortical (TC) circuits regulate sleep spindle activity through communications that are filtered by the inhibitory thalamic reticular nucleus (TRN); however, little is known about typical TC network interactions and the mechanisms that are disrupted in brain disorders. We developed a primate-specific, circuit-based TC computational model with distinct core and matrix loops that can simulate sleep spindles. We implemented novel multilevel cortical and thalamic mixing, and included local thalamic inhibitory interneurons, and direct layer 5 projections of variable density to TRN and thalamus to investigate the functional consequences of different ratios of core and matrix node connectivity contribution to spindle dynamics. Our simulations showed that spindle power in primates can be modulated based on the level of cortical feedback, thalamic inhibition, and engagement of model core versus matrix, with the latter having a greater role in spindle dynamics. The study of the distinct spatial and temporal dynamics of core-, matrix-, and mix-generated sleep spindles establishes a framework to study disruption of TC circuit balance underlying deficits in sleep and attentional gating seen in autism and schizophrenia.https://direct.mit.edu/netn/article/7/2/743/115199/Sleep-spindles-in-primates-Modeling-the-effects-of |
| spellingShingle | Arash Yazdanbakhsh Helen Barbas Basilis Zikopoulos Sleep spindles in primates: Modeling the effects of distinct laminar thalamocortical connectivity in core, matrix, and reticular thalamic circuits Network Neuroscience |
| title | Sleep spindles in primates: Modeling the effects of distinct laminar thalamocortical connectivity in core, matrix, and reticular thalamic circuits |
| title_full | Sleep spindles in primates: Modeling the effects of distinct laminar thalamocortical connectivity in core, matrix, and reticular thalamic circuits |
| title_fullStr | Sleep spindles in primates: Modeling the effects of distinct laminar thalamocortical connectivity in core, matrix, and reticular thalamic circuits |
| title_full_unstemmed | Sleep spindles in primates: Modeling the effects of distinct laminar thalamocortical connectivity in core, matrix, and reticular thalamic circuits |
| title_short | Sleep spindles in primates: Modeling the effects of distinct laminar thalamocortical connectivity in core, matrix, and reticular thalamic circuits |
| title_sort | sleep spindles in primates modeling the effects of distinct laminar thalamocortical connectivity in core matrix and reticular thalamic circuits |
| url | https://direct.mit.edu/netn/article/7/2/743/115199/Sleep-spindles-in-primates-Modeling-the-effects-of |
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